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L-Homocystine

Product Name
L-Homocystine
CAS No.
626-72-2
Chemical Name
L-Homocystine
Synonyms
(2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid);H-HoCys-OH;(H-HCY-OH)2;(H-Hcy-OH)?;H-L-HCystine;(H-HOCYS-OH)2;H-L-HOCYSTINE;(H-Hcys-OH) 2;L-Homocystine;L-Homocystine
CBNumber
CB5155903
Molecular Formula
C8H16N2O4S2
Formula Weight
268.35
MOL File
626-72-2.mol
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L-Homocystine Property

Melting point:
281-284 °C (dec.)(lit.)
alpha 
77 º (c=1% in 1N HCl)
Boiling point:
507.6±50.0 °C(Predicted)
Density 
1.443±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O : 5 mg/mL (18.63 mM; ultrasonic and adjust pH to 3 with H2O)DMSO : 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl)
form 
Powder
pka
1.90±0.10(Predicted)
color 
Off-white to light yellow
BRN 
1728583
InChIKey
ZTVZLYBCZNMWCF-WDSKDSINSA-N
CAS DataBase Reference
626-72-2(CAS DataBase Reference)
EPA Substance Registry System
L-Homocystine (626-72-2)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H6010
Product name
L-Homocystine
Purity
≥98% (HPLC)
Packaging
100mg
Price
$121
Updated
2024/03/01
Sigma-Aldrich
Product number
H6010
Product name
L-Homocystine
Purity
≥98% (HPLC)
Packaging
1g
Price
$597
Updated
2024/03/01
Sigma-Aldrich
Product number
H6010
Product name
L-Homocystine
Purity
≥98% (HPLC)
Packaging
500mg
Price
$347
Updated
2024/03/01
Usbiological
Product number
H7000
Product name
L-Homocystine, 99%
Packaging
1g
Price
$330
Updated
2021/12/16
TRC
Product number
H591360
Product name
L-Homocystine
Packaging
10g
Price
$145
Updated
2021/12/16
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L-Homocystine Chemical Properties,Usage,Production

Chemical Properties

L-homocysteine is an aliphatic amino acid with the molecular formula (C8H16N2O4S2). It is a white powder with an acidic taste and is easily soluble in water. It has limited solubility in ethanol. L-homocysteine has a sulfhydryl group on its side chain, which allows it to form disulfide bonds with other L-homocysteine residues in proteins. This feature contributes to the stable three-dimensional structure of proteins. As a result, L-homocysteine finds extensive applications in industries such as pharmaceuticals, food, feed, and cosmetics.

Uses

Increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.

Definition

ChEBI: L,L-homocystine is a homocystine in which both chiral centres have L configuration. It is functionally related to a L-homocysteine. It is a tautomer of a L,L-homocystine zwitterion.

Synthesis

L-homoserine(626-72-2) is biosynthesized from L-aspartate, which is synthesized from oxaloacetate, a TCA cycle intermediate. Homoserine is activated through esterification to form the O-acetyl ester by the enzyme homoserine O-acetyltransferase. In certain organisms, including the yeast Saccharomyces cerevisiae and certain bacteria, hydrogen sulfide reacts with O-acetyl-L-homoserine, replacing the acetyl group and forming L-homocysteine.

Purification Methods

The acid (3g) is dissolved in freshly boiled H2O (30mL) under N2, cooled under N2 (all operations should be under N2), absolute EtOH (100mL) is added, the acid is filtered off, and a second crop is obtained by diluting the filtrate to 500mL with absolute EtOH, kept overnight in a refrigerator, filtered, washed with EtOH and dried in a vacuum. The D(R,R)-form has similar properties but is –ve in M HCl and +ve in H2O. [du Vigneaud & Patterson J Biol Chem 109 101 1935, du Vigneaud & Brown Biochemical Preparations 5 93, 95 1975, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2667-2670 1961, Beilstein 4 III 1643, 4 IV 3199, Koegel et al. J Am Chem Soc 77 5708 1955.]

L-Homocystine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Homocystine Suppliers

Canada 1 China 194 Germany 5 India 4 Japan 2 Switzerland 4 The Netherlands 2 United Kingdom 4 United States 31 Global 247
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from L-Homocystine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Homocystine 626-72-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
5000kg/month
Release date
2021-10-13
Henan Bao Enluo International TradeCo.，LTD
Product
L-Homocystine 626-72-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500t/month
Release date
2023-08-01
Guangzhou Sunton Biotechnology Co., Ltd.
Product
L-Homocystine 626-72-2
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20tons
Release date
2021-06-18

626-72-2, L-HomocystineRelated Search:

4-Aminobutyric acid D-2-Aminobutyric acid N-Acetyl-L-cysteine DL-Homocysteine L-Cystine DL-2-AMINOBUTYRIC ACID L-Cysteine Selenium sulfide DL-3-Aminobutyric acid Cyproterone acetate Indole-3-butyric acid DL-2-Aminobutyric acid L(+)-2-Aminobutyric acid 3-CARBOXYPROPYL DISULFIDE Butyl disulfide Methyl propyl disulfide r-Amino Butryric Acid ETHYL PROPYL DISULFIDE

  • (2S,2'S)-2,2'-Diamino-(4,4'-dithiobisbutyric acid)
  • 3,3'-(Dithiobismethylene)bisalanine
  • 4,4'-Dithiobis[(2S)-2-aminobutanoic acid]
  • 4,4'-Dithiobis[(S)-2-aminobutanoic acid]
  • 4,4'-Dithiobis[(S)-2-aminobutyric acid]
  • (2S,2'S)-4,4'-Disulfanediylbis(2-aMinobutanoic acid)
  • (2S,2'S)-4,4'-Dithiobis[2-aMinobutanoic Acid]
  • [S-(R*,R*)]-4,4'-Dithiobis[2-aMinobutanoic Acid]
  • L-Homocystine ,99%
  • L-Homocystine,L-4,4′-Dithiobis(2-aminobutanoic acid)
  • L-HOMOCYSTINE, >=98% (HPLC)
  • (H-L-HomoCys-OH)2
  • L-Homocystine≥ 99% (Assay)
  • H-HoCys-OH L-4,4'-Dithiobis(2-aminobutanoic acid)
  • (H-HCY-OH)2
  • (H-HOCYS-OH)2
  • (H-HOMOCYS-OH)2
  • H-L-HOCYSTINE
  • L-4,4'-DITHIO-BIS(2-AMINOBUTANOIC ACID)
  • 4,4’-dithiobis[2-amino-,[s-(theta,theta)]-butanoicaci
  • (H-Hcy-OH)?
  • L-homocystine cell culture tested
  • [S-(R*,R*)]-4,4'-dithiobis[2-aminobutyric] acid
  • 2-amino-4-(3-amino-3-carboxy-propyl)disulfanyl-butanoic acid
  • H-HoCys-OH
  • (H-Hcys-OH) 2
  • L-Homocystine
  • H-L-HCystine
  • (2S)-2-amino-4-{[(3S)-3-amino-3-carboxypropyl]disulfanyl}butanoic acid
  • Butanoic acid, 4,4'-dithiobis[2-amino-, (2S,2'S)-
  • L-Homocystine USP/EP/BP
  • L Homocystine,Inhibitor,Endogenous Metabolite,LHomocystine,inhibit,L-Homocystine
  • L-Homocystine
  • Vincamine Impurity 1( Vincamine EP Impurity A )
  • 626-72-2
  • C8H16N2O4S2
  • Unnatural Amino Acid Derivatives
  • Specialty Synthesis
  • Peptide Synthesis
  • Homo-Amino Acids
  • Amines
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Amino Acids