Cycloguanil Hydrochloride

Product Name: Cycloguanil Hydrochloride
CAS No.: 152-53-4
Chemical Name: Cycloguanil Hydrochloride
Synonyms: uaniL;BN 2410;oguaniL;NSC 3074;NSC 3074-d4;Chloroprimidine;Chloroguanide Triazine;Cycloguanil Hydrochloride;Cycloguanil-d4 Hydrochloride;Cycloguanidine hydrochloride
CBNumber: CB51564793
Molecular Formula: C11H14ClN5.ClH
Formula Weight: 288.181
MOL File: 152-53-4.mol

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Cycloguanil Hydrochloride Property

Melting point:: 210-2150C
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S392502
Product name: 1-(4-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1,3,5-TRIAZINE HCL
Purity: AldrichCPR
Packaging: 50MG
Price: $179
Updated: 2024/03/01

Cayman Chemical

Product number: 16861
Product name: Cycloguanil (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16861
Product name: Cycloguanil (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 16861
Product name: Cycloguanil (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 16861
Product name: Cycloguanil (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $139
Updated: 2024/03/01

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Cycloguanil Hydrochloride Chemical Properties,Usage,Production

Description

Cycloguanil is the active metabolite of the antimalarial prodrug proguanil. Cycloguanil is formed from proguanil by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A in human liver microsomes. It is an inhibitor of dihydrofolate reductase (DHFR; K_is = 1.5 and 0.79 nM for the P. falciparum and P. berghei enzymes, respectively). It is active against ten P. falciparum field isolates (IC₅₀s = 0.12-1,400 μg/ml). Cycloguanil reduces parasitemia in a mouse model of P. berghei infection (ED₅₀ = 2 mg/kg). It also reduces parasitemia in a rhesus monkey model of P. cynomolgi infection when administered at a dose of 0.3 mg/kg.

Chemical Properties

Crystalline Solid

Uses

Labelled antimalarial drug

Uses

Antimalarial drug.

Definition

ChEBI: Cycloguanil hydrochloride is the hydrochloride salt of cycloguanil. It is an organic molecular entity and a hydrochloride. It contains a cycloguanil.

References

[1] foote s j, galatis d, cowman a f. amino acids in the dihydrofolate reductase-thymidylate synthase gene of plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance[j]. proceedings of the national academy of sciences, 1990, 87(8): 3014-3017.
[2] blakley r l. dihydrofolate reductase[j]. encyclopedia of molecular medicine, 1984.
[3] birkett d j, rees d, andersson t, et al. in vitro proguanil activation to cycloguanil by human liver microsomes is mediated by cyp3a isoforms as well as by s‐mephenytoin hydroxylase[j]. british journal of clinical pharmacology, 1994, 37(5): 413-420.

Cycloguanil Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Cycloguanil Hydrochloride Suppliers

Canada 1 China 48 India 2 United Kingdom 1 United States 13 USA 1 Global 66

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
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Adamas Reagent, Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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Email: shchemsky@sina.com
Country: China
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Bide Pharmatech Ltd.

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Artis Biotech Co. Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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Cycloguanil D6 HydrochlorideQ: What is Cycloguanil D6 Hydrochloride Q: What is the CAS Number of Cycloguanil D6 Hydrochloride Q: What is the storage condition of Cycloguanil D6 Hydrochloride Q: What are the applications of Cycloguanil D6 Hydrochloride

Chloroprimidine

Cycloguanidine hydrochloride

Cycloguanil,Inhibitor,Parasite,Drug Metabolite,Cycloguanil hydrochloride,inhibit

152-53-4

C11H11D4Cl2N5

C11H15Cl2N5

C11H14ClN5HCl

Aromatics Compounds

aromatics

Bases & Related Reagents

Heterocycles

Intermediates & Fine Chemicals

Nucleotides

Pharmaceuticals

Isotope Labeled Compounds

Isotope Labelled Compounds