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rac-Sitagliptin

Product Name
rac-Sitagliptin
CAS No.
823817-56-7
Chemical Name
rac-Sitagliptin
Synonyms
rac-Sitagliptin-d4;7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine;3-aMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;rac-Sitagliptin;Sitagliptin chiral isomer;3-a]pyrazin-7(8H)-yl]-4-(2;rac-SitagliptinSee: S491000;5-trifluorophenyl)-1-butanone;3-Amino-1-[3-(trifluoromethyl)-5;7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine
CBNumber
CB51564874
Molecular Formula
C16H15F6N5O
Formula Weight
407.31
MOL File
823817-56-7.mol
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rac-Sitagliptin Property

Boiling point:
529.9±60.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO, Ethyl Acetate, Methanol
pka
7.20±0.10(Predicted)
form 
Oil
color 
Yellow to Light Brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
020965
Product name
rac-Sitagliptin
Packaging
1mg
Price
$340
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO103288
Product name
Sitagliptin impurity E
Packaging
10mg
Price
$500
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO103288
Product name
Sitagliptin impurity E
Packaging
25mg
Price
$800
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO103288
Product name
Sitagliptin impurity E
Packaging
50mg
Price
$1200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FO103288
Product name
Sitagliptin impurity E
Packaging
100mg
Price
$1700
Updated
2021/12/16
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rac-Sitagliptin Chemical Properties,Usage,Production

Chemical Properties

Light Brown Syrup

Uses

A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes.

in vivo

In vivo, the ED50 value of sitagliptin phosphate for inhibition of plasma DPP-4 activity is calculated to be 2.3 mg/kg 7 hour postdose and 30 mg/kg 24 hour postdose in freely fed Han-Wistar rats[1].?The streptozotocin-induced type 1 diabetes mouse model exhibits elevated DPP-4 levels in the plasma that can be substantially inhibited in mice on an Sitagliptin phosphate diet. This is achieved by a positive effect on the regulation of hyperglycemia, potentially through prolongation of islet graft survival[4].?The plasma clearance and volume of distribution of Sitagliptin phosphate are higher in rats (40-48 mL/min/kg, 7-9 L/kg) than in dogs (9 mL/min/kg, 3 L/kg); and its half-life is shorter in rats,2 hours compared with 4 hours in dogs[5].

rac-Sitagliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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rac-Sitagliptin Suppliers

Canada 1 China 44 India 6 United Kingdom 1 United States 9 Global 61
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Suzhou lipin Chemical Co., Ltd
Tel
0512-0512-67509664 19888480046
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China
ProdList
121
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58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
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China
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10268
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Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
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58
Chengdu Miracle Pharmaceutical Co., Ltd.
Tel
028-86136736 19130631884
Fax
028-85265615
Email
sales@mic-pharma.com
Country
China
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295
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56
BOC Sciences
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16314854226
Email
info@bocsci.com
Country
United States
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9923
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65
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1850
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Artis Biotech Co. Ltd.
Tel
19138486554 18108108965
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
5329
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58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
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62

823817-56-7, rac-SitagliptinRelated Search:

Sitagliptin phosphate Methyl 3-acetamido-4-(2,4,5-trifluorophenyl)but-2-enoate (S)-Sitagliptin Phosphate Sitagliptin Impurity 34 Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate 1,2,4-Triazolo[4,3-a]pyrazine, 7-[3-amino-1-oxo-4-(2,4,5-trifluorophenyl)-2-butenyl]-5,6,7,8-tetrahydro- 3-(trifluoromethyl)- Sitagliptin Defuoro IMpurity 3 Sitagliptin DeaMino IMpurity 1 (2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-one Sitagliptin Impurity 1 Sitagliptin Impurity 26 Sitagliptin Impurity 14 Sitagliptin IMpurity Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- (R)-3-Amino-4-(2,4,5-trifluorophenyl)butyric acid 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Sitagliptin Sitagliptin EP Impurity B

  • 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine
  • 7-[3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
  • rac-SitagliptinSee: S491000
  • 3-AMino-1-[3-(trifluoroMethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone
  • 7-[1-Oxo-3-amino-4-(2,4,5-trifluorophenyl)butyl]-3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine
  • 3-aMino-1-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
  • rac-Sitagliptin
  • 1-Butanone,3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-
  • 3-Amino-1- [3- (trifluoromethyl) -5,6,7,8-tetrahydro-1,2,4-triazolo [4,3-a] pyrazin-7-yl] -4- (2,4,5-trifluorophenyl) butan-1
  • 3-a]pyrazin-7(8H)-yl]-4-(2
  • 3-Amino-1-[3-(trifluoromethyl)-5
  • 5-trifluorophenyl)-1-butanone
  • Sitagliptin chiral isomer
  • rac-Sitagliptin-d4
  • 823817-56-7
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