HUMAN RANTES
Description Source Background- Product Name
- HUMAN RANTES
- CAS No.
- 1927910-48-2
- Chemical Name
- HUMAN RANTES
- Synonyms
- CCL8;HC14;MCP-2;SCYA8;SCYA10;RHRANTES;HUMAN CCL5;MCP-2, HUMAN;HUMAN RANTES;RANTES, HUMAN
- CBNumber
- CB5157790
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN RANTES Property
- storage temp.
- −20°C
- form
- lyophilized powder
- color
- white
- biological source
- mouse
Safety
- Hazard Codes
- T,Xn,F
- Risk Statements
- 23/24/25-36/37/38-36-20/21/22-11
- Safety Statements
- 26-36/37/39-45-36/37-16
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SRP3269
- Product name
- RANTES human
- Purity
- Animal-component free, recombinant, expressed in <I>E. coli</I>, ≥98% (SDS-PAGE), ≥98% (HPLC)
- Packaging
- 20 μg
- Price
- $452
- Updated
- 2025/07/31
- Product number
- R1100-05D
- Product name
- RANTES, Human
- Packaging
- 96Tests
- Price
- $835
- Updated
- 2021/12/16
- Product number
- orb527550
- Product name
- CCL8
- Packaging
- 10μg
- Price
- $290.7
- Updated
- 2021/12/16
- Product number
- CYT0000037
- Product name
- CCL-8
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.7
- Updated
- 2021/12/16
HUMAN RANTES Chemical Properties,Usage,Production
Uses
RANTES human has been used in following studies:
- In transmigration experiments to determine whether LFA-1 cross-linking could affect peripheral blood T lymphocytes (PBTL) migration in response to the chemokine RANTES.
- Luminol-dependent chemiluminescence assay to determine the effect of RANTES on reactive oxygen species (ROS) production by eosinophils.
Biological Activity
Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4+/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5.1 RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. The In1.1C variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV-1 infection.
Description
Monocyte Chemotactic Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 8904 Dalton.
The MCP2 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. Rantes has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-g) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. Rantes is also an HIV-suppressive factor released from CD8+ T cells. The Rantes chemokine has been localized to chromosome 17 in humans.
HUMAN RANTES Preparation Products And Raw materials
Raw materials
Preparation Products
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