BZ-TYR-4-ABZ-OH

Product Name: BZ-TYR-4-ABZ-OH
CAS No.: 37106-97-1
Chemical Name: BZ-TYR-4-ABZ-OH
Synonyms: e-2663;chymex;btpaba;BTPABA,PFT;BENTIROMIDE;BZ-TYR-4-ABZ-OH;BentiroMide, BTPABA;benzoyltyrosyl-p-aminobenzoicacid;N-Benzoyl-L-tyrosyl-p-aminobenzoate;n-benzoyl-l-tyrosyl-p-aminobenzoicacid
CBNumber: CB5161221
Molecular Formula: C23H20N2O5
Formula Weight: 404.42
MOL File: 37106-97-1.mol

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BZ-TYR-4-ABZ-OH Property

Melting point:: 240-242°
alpha: D25 +72.3° (c = 1 in DMF) (US 3801562); D25 +87° (c = 1 in DMF) (De Benneville)
Boiling point:: 526.04°C (rough estimate)
Density: 1.3093 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: Store at RT.
solubility: DMSO:250.0(Max Conc. mg/mL);618.17(Max Conc. mM)
form: Solid
pka: 4.27±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 265226
Product name: Bz-Tyr-4-Abz-OH
Packaging: 500mg
Price: $213
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49255
Product name: Bz-Tyr-4-Abz-OH
Packaging: 1g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB49255
Product name: Bz-Tyr-4-Abz-OH
Packaging: 2g
Price: $400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004601
Product name: BENTIROMIDE
Purity: 95.00%
Packaging: 5MG
Price: $403.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0004601
Product name: BENTIROMIDE
Purity: 95.00%
Packaging: 250MG
Price: $570
Updated: 2021/12/16

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BZ-TYR-4-ABZ-OH Chemical Properties,Usage,Production

Originator

PFD Oral Sol,Eisai,Japan,1980

Uses

Diagnostic aid (pancreas function determination).

Definition

ChEBI: The dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic t erapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.

Manufacturing Process

A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g, 0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the mixture was cooled to room temperature, and the precipitate of tyrosine hydrochloride filtered off (11 g, 46 meq. Cl-). The THF was evaporated and the residue extracted with CCl4 (3 X 100 ml at reflux, discarded) and then dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate solution was evaporated to yield 132 g solid product, MP 159°-162°C (93%). The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from the hydrochloride.
A solution was made of N-benzyl-L-tyrosine (5.7 g, 20 mmols) and Nmethylmorpholine (2.04 g, 20 mmols) in 60 ml of THF, at -15°C, and to it was added ethyl chloroformate (2.08 g, 20 mmols). After 12 minutes, paminobenzoic acid (2.74 g, 20 mmols) dissolved in 25 ml of THF and 0.38 g of p-toluenesulfonic acid (2 mmols) were added, and the temperature allowed to rise to 5°C. After 2 hours and forty minutes, the mixture was poured into l liter of 0.1 N cold HCl, stirred one-half hour, filtered and dried, to give 8,7 g, MP 192°-223°C. The product was recrystallized from 90 ml methanol and 40 ml water, to give 6 g (74%) of product, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, MP 240°-242°C.

brand name

Chymex (Savage).

Therapeutic Function

Diagnostic aid (pancreatic function)

BZ-TYR-4-ABZ-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BZ-TYR-4-ABZ-OH Suppliers

China 40 India 1 United Kingdom 2 United States 11 USA 1 Global 55

Shanghai Hanhong Scientific Co.,Ltd.

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Nanjing Peptide Biotech Ltd.

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BOC Sciences

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Dayang Chem (Hangzhou) Co.,Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Nanjing chengqimei Biotechnology Co., Ltd

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37106-97-1, BZ-TYR-4-ABZ-OHRelated Search:

PANCREATIC POLYPEPTIDE (RANA TEMPORARIA) Secretin (human) CHEMBRDG-BB 9071855 BZ-PHE-NH2 4-(BUTYLAMINO)BENZOIC ACID AC-TYR-NHME BZ-TYR-4-ABZ-OH 4-Acetamidobenzaldehyde BZ-TYR-NH2 BZ-TYR-4-ABZ-OH SODIUM SALT,BZ-TYR-4-ABZ-OH NA SALT,BENTIROMIDE,bentiromide sodium,Bentiromide, N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt p-Acetylamino benzoic acid 4-(propionylamino)benzoic acid AC-TYR-NH2

BZ-TYR-4-ABZ-OH

BENTIROMIDE

btpaba

chymex

e-2663

n-benzoyl-l-tyrosyl-p-aminobenzoicacid

p-((n-benzoyl-l-tyrosin)amido)benzoicacid

4-(N-Benzoyl-L-tyrosyl)aminobenzoic acid

Benzoic acid, 4-[[(2S)-2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-

Benzoic acid, 4-[[2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-, (S)-

N-Benzoyl-L-tyrosyl-p-aminobenzoate

4-[[(S)-2-(Benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl]amino]benzoic acid

BTPABA,PFT

(s)-4-((2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoicacid

(s)-p-(alpha-benzamido-p-hydroxyhydrocinnamamido)benzoicacid

4-((2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)-benzoicaci(s)

4-((2-(benzoylamino)-3-(4-hydroxyphenyl)-1-oxopropyl)amino)benzoicacid

benzoyltyrosyl-p-aminobenzoicacid

BentiroMide, BTPABA

(S)-4-(2-Benzamido-3-(4-hydroxyphenyl)propanamido)benzoic acid

37106-97-1

C23H20N2O5