4-(BUTYLAMINO)BENZOIC ACID
- Product Name
- 4-(BUTYLAMINO)BENZOIC ACID
- CAS No.
- 4740-24-3
- Chemical Name
- 4-(BUTYLAMINO)BENZOIC ACID
- Synonyms
- NSC44300;NSC 44300;SMR000413195;MLS000776796;CBDivE_002387;STOCK1S-53913;262412_ALDRICH;Tetracaine Impurity B;LABOTEST-BB LT00000179;Tetracaine EP Impurity B
- CBNumber
- CB6137539
- Molecular Formula
- C11H15NO2
- Formula Weight
- 193.24
- MOL File
- 4740-24-3.mol
4-(BUTYLAMINO)BENZOIC ACID Property
- Melting point:
- 149-151 °C(lit.)
- Boiling point:
- 353.5±25.0 °C(Predicted)
- Density
- 1.130±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 4.77±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 262412
- Product name
- 4-(Butylamino)benzoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $348
- Updated
- 2025/07/31
- Product number
- PHR2236
- Product name
- Tetracaine Related Compound B
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 50mg
- Price
- $587.1
- Updated
- 2025/07/31
- Product number
- 1650017
- Product name
- Tetracaine Related Compound B
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 25mg
- Price
- $1200
- Updated
- 2025/07/31
- Product number
- 262412
- Product name
- 4-(Butylamino)benzoic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $416
- Updated
- 2025/07/31
- Product number
- B689445
- Product name
- 4-(Butylamino)benzoic acid
- Packaging
- 5g
- Price
- $275
- Updated
- 2021/12/16
4-(BUTYLAMINO)BENZOIC ACID Chemical Properties,Usage,Production
Uses
4-(Butylamino)benzoic Acid is an intermediate used to synthesize 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus.
Definition
ChEBI: 4-Aminobenzoic acid in which one of the hydrogens attached to the nitrogen is substituted by a butyl group.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
150-13-0
123-72-8
4740-24-3
4-(Butylamino)benzoic acid (compound 3) was synthesized as follows: compound 2 (about 3 mmol) was dissolved in 15 mL of methanol, R-methylpyridine-borane (1.1 eq.) and n-butyraldehyde (1.1 eq.) were added. The reaction mixture was sealed with a vented pin plug and the reaction was stirred at room temperature for 16-24 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, 10 mL of 1 M HCl solution was added and stirring was continued for 30 minutes at room temperature. Subsequently, the pH was adjusted to neutral with NaHCO3 solution and the target product was extracted with ethyl acetate (2 x 60 mL). The organic layers were combined, washed once with brine (45 mL), dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Finally, the target product compound 3 was purified by column chromatography (eluent: hexane solution of 30% ethyl acetate) to give the target product compound 3 in white powder form in 88% yield. The structure of the product was confirmed by 1H NMR (500 MHz, CD3OD) and 13C NMR (125 MHz, CD3OD).
References
[1] Journal of Organic Chemistry, 2007, vol. 72, # 25, p. 9815 - 9817
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4904 - 4912
[3] Patent: US2014/18422, 2014, A1. Location in patent: Paragraph 0098
4-(BUTYLAMINO)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(BUTYLAMINO)BENZOIC ACID manufacturers
- Product
- 4-(BUTYLAMINO)BENZOIC ACID 4740-24-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-09