Uses Description Mechanism of Action Precautions Application Dosage Side Effects
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Tetracaine

Uses Description Mechanism of Action Precautions Application Dosage Side Effects
Product Name
Tetracaine
CAS No.
94-24-6
Chemical Name
Tetracaine
Synonyms
TETRACAINE BASE;Tetracaina;Dicaine;amethocaine;TETRACAIN;Tetracainum;Dlcalne;Medicaine;Tetracacine;2-(Dimethylamino)ethyl 4-(butylamino)benzoate
CBNumber
CB9775567
Molecular Formula
C15H24N2O2
Formula Weight
264.36
MOL File
94-24-6.mol
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Tetracaine Property

Melting point:
41.0 to 45.0 °C
Boiling point:
407.59°C (rough estimate)
Density 
1.0200 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
pKa 8.33±0.03(H2O t = 20.0 I = 0.10 (KCl)) (Uncertain)
color 
White to Almost white
Water Solubility 
156mg/L(temperature not stated)
InChI
InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey
GKCBAIGFKIBETG-UHFFFAOYSA-N
SMILES
C(OCCN(C)C)(=O)C1=CC=C(NCCCC)C=C1
LogP
3.510
CAS DataBase Reference
94-24-6(CAS DataBase Reference)
NIST Chemistry Reference
Tetracaine(94-24-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-40-42/43-43
Safety Statements 
22-36/37
RIDADR 
UN 2811
WGK Germany 
3
RTECS 
DG4725000
HazardClass 
6.1
PackingGroup 
III
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H317May cause an allergic skin reaction

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0002117
Product name
Tetracaine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002117
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
T7383
Product name
Tetracaine
Purity
≥98% (TLC)
Packaging
25G
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
T7383
Product name
Tetracaine
Purity
≥98% (TLC)
Packaging
100G
Price
$537
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR3140
Product name
Tetracaine
Purity
pharmaceutical secondary standard, certified reference material
Packaging
100MG
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
1649991
Product name
Tetracaine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$381
Updated
2024/03/01
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Tetracaine Chemical Properties,Usage,Production

Uses

Tetracaine is used in assessing the potential for drug-nanoparticle surface interactions to improve drug penetration into the skin.

Description

Tetracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. Normally, the drug is administered before starting a surgery to decrease pain from the procedure. Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes.

Mechanism of Action

Tetracaine acts by blocking the nerve systems. It does this by blocking the sodium ion channels needed for the conduction and initiation of neural impulses, thereby affecting the local anesthesia. Tetracaine acts by altering the function of calcium release channels that controls the release of calcium frim intracellular cells.

Precautions

No studies have revealed whether the medicine can affect an unborn child; however, it is important to inform the doctor if pregnant while using it.

Informing the doctor is paramount if breastfeeding a baby, as no known research has illustrated whether tetracaine can pass into breast milk or harm a nursing baby.

To make tetracaine safe, it is important to inform the doctor if one has a history of spinal or brain injury, heart diseases, eye problems, a blood vessel disorder, open sores, skin injury in the area where the medicine will be applied.

Tetracaine should never be orally taken since it is typically designed for use on the skin only. If the medicine gets in the mouth, nose, vagina, or rectum, rinse with water.

Application

Tetracaine topical (for the skin) is used to numb various body parts before a surgical procedure or a medical test. Conversely, tetracaine ophthalmic drops are used as local anesthetic for the eyes.

Dosage

Always follow all direction on the prescription label. Do not use the medicine in smaller or larger amounts or for longer than recommended.

Side Effects

Seek emergency medical advice in case of any of the following allergic reactions: difficult breathing, hives, swelling of the throat, tongue, lips, or face. Stop using the drug and call the physician if one has severe burning, swelling, stinging, or other irritation of the treated skin. Other alarming symptoms include eye watering, irritation, and increased sensitivity to light.

Common side effects include burning, stinging, or itching at the point of application of the medicine; numbness in places where tetracaine has been accidentally applied or skin redness or tenderness.

Nonclinical Toxicology
Studies conducted to reveal the genotoxicity of tetracaine have not indicated its mutagenesis, carcinogenicity, or impairment of fertility.

Chemical Properties

White or light-yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, ether, benzene, chloroform.

Uses

analgesic

Uses

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

Uses

Topical ophthalmic anesthetic; used for spinal anesthesia

Uses

Tetracaine, also known as amethocaine, is the most potent and lipidsoluble ester local anaesthetic and has significant potential for toxicity if used systemically. It is commonly used as a 4% gel for topical application to decrease the pain from venous puncture or cannulation.

Definition

ChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.

Biological Functions

Tetracaine hydrochloride (Pontocaine) is an ester of PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid) anesthesia. Epinephrine is frequently added to prolong the anesthesia.Tetracaine is considerably more potent and more toxic than procaine and cocaine. It has approximately a 5-minute onset and 2 to 3 hours of action.

General Description

Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

Biochem/physiol Actions

Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Veterinary Drugs and Treatments

Tetracaine is more irritating than proparacaine but is sometimes used in veterinary medicine. It is indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Tetracaine is also indicated to produce local anesthesia prior to surgical procedures in humans such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solution enters the eye through the incision.

Tetracaine Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetracaine Suppliers

Changzhou josenchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
519-519-85286950 13338194135
Fax
0519-85286950
Email
info@josenchem.com
Country
China
ProdList
75
Advantage
58
Changzhou Tianhua Pharmaceutical Co., Ltd.
Tel
0519-82891186 18651213286
Fax
0519-82899734
Email
tianhua@tianhuachem.com
Country
China
ProdList
83
Advantage
58
Changzhou Sunlight Farmacéutica.S.L.
Tel
0519-83138357,15851985467 13706121722
Fax
0519-83138041
Email
810308@sunlightchem.com
Country
China
ProdList
37
Advantage
60
Jinan Xuanzheng Pharmaceutical Co. LTD
Tel
18610218799
Email
xuanzhengyaoye@126.com
Country
China
ProdList
14
Advantage
58
Jinan Junnuo Trading Co., LTD
Tel
13345898948
Email
1301260554@qq.com
Country
China
ProdList
114
Advantage
58
Hebei Mujin Biological Technology Co., LTD
Tel
13288715308
Email
emma@hbmojin.com
Country
China
ProdList
39
Advantage
58
Hebei Mujin Biological Technology Co., LTD
Tel
17731199419
Email
jessica@hbmojin.com
Country
China
ProdList
50
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.
Tel
0519-85195575 15861192208
Fax
85195585
Email
850305@sunkechem.com
Country
China
ProdList
75
Advantage
69
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
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View Lastest Price from Tetracaine manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Tetracaine 94-24-6
Price
US $999.00-666.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Tetracaine 94-24-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-09-23
Dorne Chemical Technology co. LTD
Product
Tetracaine 94-24-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-03-26

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