BZ-TYR-4-ABZ-OH
- Product Name
- BZ-TYR-4-ABZ-OH
- CAS No.
- 37106-97-1
- Chemical Name
- BZ-TYR-4-ABZ-OH
- Synonyms
- e-2663;chymex;btpaba;BTPABA,PFT;BENTIROMIDE;BZ-TYR-4-ABZ-OH;BentiroMide, BTPABA;benzoyltyrosyl-p-aminobenzoicacid;N-Benzoyl-L-tyrosyl-p-aminobenzoate;n-benzoyl-l-tyrosyl-p-aminobenzoicacid
- CBNumber
- CB5161221
- Molecular Formula
- C23H20N2O5
- Formula Weight
- 404.42
- MOL File
- 37106-97-1.mol
BZ-TYR-4-ABZ-OH Property
- Melting point:
- 240-242°
- alpha
- D25 +72.3° (c = 1 in DMF) (US 3801562); D25 +87° (c = 1 in DMF) (De Benneville)
- Boiling point:
- 526.04°C (rough estimate)
- Density
- 1.3093 (rough estimate)
- refractive index
- 1.6300 (estimate)
- storage temp.
- Store at RT.
- solubility
- DMSO:250.0(Max Conc. mg/mL);618.17(Max Conc. mM)
- form
- Solid
- pka
- 4.27±0.10(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 265226
- Product name
- Bz-Tyr-4-Abz-OH
- Packaging
- 500mg
- Price
- $213
- Updated
- 2021/12/16
- Product number
- 07938
- Product name
- Bz-Tyr-4-Abz-OH,≥99%(TLC)
- Purity
- ≥99%(TLC)
- Packaging
- 250MG
- Price
- $81.54
- Updated
- 2021/12/16
- Product number
- 07938
- Product name
- Bz-Tyr-4-Abz-OH,≥99%(TLC)
- Purity
- ≥99%(TLC)
- Packaging
- 1G
- Price
- $163.07
- Updated
- 2021/12/16
- Product number
- FB49255
- Product name
- Bz-Tyr-4-Abz-OH
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB49255
- Product name
- Bz-Tyr-4-Abz-OH
- Packaging
- 2g
- Price
- $400
- Updated
- 2021/12/16
BZ-TYR-4-ABZ-OH Chemical Properties,Usage,Production
Originator
PFD Oral Sol,Eisai,Japan,1980
Uses
Diagnostic aid (pancreas function determination).
Definition
ChEBI: The dipeptide obtained by condensation of N-benzoyl-L-tyrosine with 4-aminobenzoic acid. Used as a noninvasive screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic t erapy, it is given by mouth: the amount of 4-aminobenzoic acid and its metabolites excreted in the urine is taken as a measure of the chymotrypsin-secreting activity of the pancreas.
Manufacturing Process
A mixture was made of L-tyrosine (18.1 g, 0.1 mol) benzoyl chloride (7.0 g,
0.05 mol) and 200 ml anhydrous THF. After stirring at reflux for 2 hours, the
mixture was cooled to room temperature, and the precipitate of tyrosine
hydrochloride filtered off (11 g, 46 meq. Cl-). The THF was evaporated and
the residue extracted with CCl4 (3 X 100 ml at reflux, discarded) and then
dissolved in ethyl acetate (200 ml) filtering off insolubles. The ethyl acetate
solution was evaporated to yield 132 g solid product, MP 159°-162°C (93%).
The tyrosine was recovered (8 g) by neutralization with aqueous alkali, from
the hydrochloride.
A solution was made of N-benzyl-L-tyrosine (5.7 g, 20 mmols) and Nmethylmorpholine (2.04 g, 20 mmols) in 60 ml of THF, at -15°C, and to it was
added ethyl chloroformate (2.08 g, 20 mmols). After 12 minutes, paminobenzoic acid (2.74 g, 20 mmols) dissolved in 25 ml of THF and 0.38 g of
p-toluenesulfonic acid (2 mmols) were added, and the temperature allowed to
rise to 5°C. After 2 hours and forty minutes, the mixture was poured into l
liter of 0.1 N cold HCl, stirred one-half hour, filtered and dried, to give 8,7 g,
MP 192°-223°C. The product was recrystallized from 90 ml methanol and 40
ml water, to give 6 g (74%) of product, N-benzoyl-L-tyrosyl-p-aminobenzoic acid, MP 240°-242°C.
brand name
Chymex (Savage).
Therapeutic Function
Diagnostic aid (pancreatic function)
BZ-TYR-4-ABZ-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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