ChemicalBook > CAS DataBase List > 7-Dehydrocholesterol

7-Dehydrocholesterol

Product Name
7-Dehydrocholesterol
CAS No.
434-16-2
Chemical Name
7-Dehydrocholesterol
Synonyms
7-DHC;NSC 18159;Provitamine;PROVITAMIN D3;7-DehydrochoL;Δ7-Cholesterol;Δ5,7-Cholesterol;provitamind(sub3);Dehydrocholesterol;Dehydrocholesterin
CBNumber
CB5165113
Molecular Formula
C27H44O
Formula Weight
384.64
MOL File
434-16-2.mol
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7-Dehydrocholesterol Property

Melting point:
148-152 °C(lit.)
alpha 
-116 º (C=1, CHCL3)
Boiling point:
451.27°C (rough estimate)
Density 
0.9717 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
-20°C
pka
14.91±0.70(Predicted)
optical activity
[α]20/D -115±8°, c = 1% in chloroform
Water Solubility 
Insoluble
Merck 
13,2887
BRN 
2224615
InChIKey
UCTLRSWJYQTBFZ-DDPQNLDTSA-N
CAS DataBase Reference
434-16-2(CAS DataBase Reference)
NIST Chemistry Reference
Cholesta-5,7-dien-3-ol, (3«beta»)-(434-16-2)
EPA Substance Registry System
Cholesta-5,7-dien-3-ol, (3.beta.)- (434-16-2)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
FZ5650000
8-10-23
HS Code 
29061990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
30800
Product name
7-Dehydrocholesterol
Purity
≥95.0% (HPLC)
Packaging
5g-f
Price
$54.2
Updated
2020/08/18
Sigma-Aldrich
Product number
30800
Product name
7-Dehydrocholesterol
Purity
≥95.0% (HPLC)
Packaging
5 g
Price
$56.1
Updated
2021/03/22
Cayman Chemical
Product number
14612
Product name
7-dehydro Cholesterol
Purity
≥90%
Packaging
10g
Price
$55
Updated
2021/03/22
Cayman Chemical
Product number
14612
Product name
7-dehydro Cholesterol
Purity
≥90%
Packaging
5g
Price
$29
Updated
2021/03/22
Cayman Chemical
Product number
14612
Product name
7-dehydro Cholesterol
Purity
≥90%
Packaging
25g
Price
$131
Updated
2021/03/22
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7-Dehydrocholesterol Chemical Properties,Usage,Production

Chemical Properties

white to off-white fine crystalline powder

Uses

A vitamin precursor.
Vitamin D3 is produced by the action of sunlight or ultraviolet irradiation from the precursor, 7-dehydrocholesterol (7-DC), that is synthesized in the skin of animals and humans.
In most tissues of the body, 7-dehydrocholesterol is the immediate precursor of cholesterol. It is reduced to cholesterol by the enzyme 3β-hydroxysterol-Δ7-reductase (DHCR7) in the last step of cholesterol biosynthesis. 7-DHC accumulates in Smith-Lemli-Opitz syndrome (SLOS), a disorder characterized by a mutation in the DHCR7 gene and decreased cholesterol levels in bodily tissues and fluids, as well as microcephaly, intellectual disability, and distinctive dysmorphic features. It is highly susceptible to free radical oxidation, giving rise to several oxysterols that may be involved in the pathogenesis of SLOS. 7-DHC levels are increased in brain, liver, and serum in a rat model of SLOS induced by the DHCR7 inhibitor AY 9944. 7-DHC is a provitamin that is converted to vitamin D3 by ultraviolet-B (UVB) light in a human skin equivalent system and in isolated human skin samples.

Uses

7-Dehydrocholesterol (7-DHC), a 5,7-conjugated diene sterol is a biosynthetic precursor of cholesterol. It helps in the production of vitamin D3 when exposed to ultraviolet B (UVB) radiation. 7-Dehydrocholesterol has been used as an internal standard to determine sterols.
7-dehydrocholesterol is used in the diagnosis of Smith-Lemli-Opitz syndrome. Blood and tissue of infants with Smith- Lemli-Opitz (SLO) syndrome contain reduced amounts of cholesterol and greatly increased concentrations of 7-dehydrocholesterol and of its isomer 8-dehydrocholesterol.

7-Dehydrocholesterol Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Dehydrocholesterol Suppliers

Shanghai QianJin Chemical Technology Co., Ltd
Tel
021-20900665-
Fax
021-20900665
Email
2986274987@qq.com
Country
China
ProdList
1363
Advantage
55
Wuhan Boye Technology Development Co., Ltd.
Tel
027-81625225-
Fax
027-81625225
Email
1973211433@qq.com
Country
China
ProdList
493
Advantage
58
Zhengzhou Kangshan Biological Co., Ltd.
Tel
0371-55023472-
Fax
0371-55023472
Email
2584787837@qq.com
Country
China
ProdList
92
Advantage
58
Puripharm Co., Ltd.
Tel
0572-2745768-1;0572-2717806-
Fax
13167223168
Email
sales@puripharm.com;yzm@puripharm.com
Country
China
ProdList
239
Advantage
65
Jiangxi ravel Biotechnology Co.,Ltd
Tel
Fax
400-880-2824
Email
hj@ruiweier.cn
Country
China
ProdList
1268
Advantage
58
Zhengzhou zhongang medicine technology co., ltd
Tel
Email
1473636384@qq.com
Country
China
ProdList
3
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20007
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from 7-Dehydrocholesterol manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
7-Dehydrocholesterol 434-16-2
Price
US $1269.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04
Baoji Guokang Bio-Technology Co., Ltd.
Product
7-Dehydrocholesterol 434-16-2
Price
US $1190.00/Kg/Bag
Min. Order
1KG
Purity
95%
Supply Ability
1T
Release date
2021-06-02
Hebei Zhanyao Biotechnology Co. Ltd
Product
7-Dehydrocholesterol 434-16-2
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-10

434-16-2, 7-DehydrocholesterolRelated Search:


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