Trifluoromethanesulfonamide
Reaction- Product Name
- Trifluoromethanesulfonamide
- CAS No.
- 421-85-2
- Chemical Name
- Trifluoromethanesulfonamide
- Synonyms
- TRIFLAMIDE;trifluoromethylsulfonamide;Trifluoromethanesulfonamide,96%;TRIFLUOROMETHANESULFOMIDE;RIFLUOROMETHANESULFONAMIDE;Trifluoromethanesulphomide;TRIFLUOROMETHANESULFONAMIDE;TRIFLUOROMETHANESULPHONAMIDE;TrifluoroMethanesulfonaMide 95%;Trifluoromethanesulphonamide98%
- CBNumber
- CB5169434
- Molecular Formula
- CH2F3NO2S
- Formula Weight
- 149.09
- MOL File
- 421-85-2.mol
Trifluoromethanesulfonamide Property
- Melting point:
- 120-124 °C(lit.)
- Boiling point:
- 164.6±45.0 °C(Predicted)
- Density
- 1.730±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.37±0.60(Predicted)
- color
- Off-White
- Water Solubility
- Soluble in water.
- BRN
- 1812099
- InChI
- InChI=1S/CH2F3NO2S/c2-1(3,4)8(5,6)7/h(H2,5,6,7)
- InChIKey
- KAKQVSNHTBLJCH-UHFFFAOYSA-N
- SMILES
- C(F)(F)(F)S(N)(=O)=O
- CAS DataBase Reference
- 421-85-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- Hazard Note
- Harmful
- HS Code
- 29350090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638455
- Product name
- Trifluoromethanesulfonamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $118
- Updated
- 2025/07/31
- Product number
- 638455
- Product name
- Trifluoromethanesulfonamide
- Purity
- 95%
- Packaging
- 5g
- Price
- $415
- Updated
- 2025/07/31
- Product number
- T1290
- Product name
- Trifluoromethanesulfonamide
- Purity
- >98.0%(T)
- Packaging
- 10g
- Price
- $110
- Updated
- 2025/07/31
- Product number
- T1290
- Product name
- Trifluoromethanesulfonamide
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $220
- Updated
- 2025/07/31
- Product number
- T792410
- Product name
- Trifluoromethylsulfonamide
- Packaging
- 25g
- Price
- $970
- Updated
- 2021/12/16
Trifluoromethanesulfonamide Chemical Properties,Usage,Production
Reaction
Trifluoromethanesulfonamide can react with paraformaldehyde in sulfuric acid to give open chain and cyclic condensation products, or in ethyl acetate to give oxy-methylated products.
Chemical Properties
White to off-white solid
Uses
Trifluoromethanesulfonamide is used as an intermediate in synthetic chemistry. It is used in the preparation of specific inhibitors of mammalian secreted phospholipases A2. It is also involved in the synthesis of ecicosanoids.
Application
It is known that benzylamine-type trifluoromethanesulfonamide derivatives such as N-benzyltrifluoromethanesulfonamide and the like and trifluoromethanesulfonamide derivatives having a condensed heterocyclic ring structure have herbicidal activity so that they are used as a herbicide.
Synthesis
15.39
trifluoromethanesulfonyl chloride dissolved in 103 g of anhydrous
isopropyl ether is charged to a reactor. The medium is cooled to 5 °C.
and the ammonia is added slowly over 2 hours. After 5 hours of stirring
at 5° C., 24.8 g of water are added to dissolve the salts. The medium is
then acidified by adding 20.7 g of a 36% aqueous hydrochloric acid
solution.
After a further addition of 13 g of water, the phases are separated.
The aqueous phase is washed with 50 g of isopropyl ether. The organic
phases are combined and the solvent is removed under reduced pressure.
10.15 g of a white solid of trifluoromethanesulfonamide are thus obtained.
Trifluoromethanesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
Trifluoromethanesulfonamide Suppliers
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- Country
- Switzerland
- ProdList
- 6968
- Advantage
- 58
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View Lastest Price from Trifluoromethanesulfonamide manufacturers
- Product
- Trifluoromethanesulfonamide 421-85-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5% min
- Supply Ability
- 2 tons/year
- Release date
- 2025-12-10
- Product
- TRIFLUOROMETHANESULFONAMIDE 421-85-2
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-25
- Product
- TRIFLUOROMETHANESULFONAMIDE 421-85-2
- Price
- US $0.00-0.00/g
- Min. Order
- 10g
- Purity
- 95%
- Supply Ability
- 20tons
- Release date
- 2024-09-19