ChemicalBook > CAS DataBase List > 4-Aminoisoquinoline

4-Aminoisoquinoline

Product Name: 4-Aminoisoquinoline
CAS No.: 23687-25-4
Chemical Name: 4-Aminoisoquinoline
Synonyms: ISOQUINOLIN-4-AMINE;NSC 170840;4-ISOQUINOLINAMINE;4-isoquinolylamine;4-lsoquinolylamine;4-AMINOISOQUINOLINE;isoqulinolin-4-amine;Isoquinolin-4-ylamine;4-Aminoisoquinoline >4-Aminoisoquinoline 97%
CBNumber: CB5172029
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 23687-25-4.mol

Less

4-Aminoisoquinoline Property

Melting point:: 108.0 to 112.0 °C
Boiling point:: 360.0±17.0 °C(Predicted)
Density: 1.210±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 6.29±0.10(Predicted)
color: White to Brown
InChI: InChI=1S/C9H8N2/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H,10H2
InChIKey: ISIUXVGHQFJYHM-UHFFFAOYSA-N
SMILES: C1C2=C(C=CC=C2)C(N)=CN=1
CAS DataBase Reference: 23687-25-4(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36
Safety Statements: 26
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933499090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 734225
Product name: 4-Aminoisoquinoline
Purity: 97%
Packaging: 1g
Price: $40
Updated: 2023/06/20

TCI Chemical

Product number: A2595
Product name: 4-Aminoisoquinoline
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: A2595
Product name: 4-Aminoisoquinoline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $178
Updated: 2025/07/31

TRC

Product number: A611600
Product name: 4-AminoIsoquinoline
Packaging: 1g
Price: $140
Updated: 2021/12/16

TRC

Product number: A611600
Product name: 4-AminoIsoquinoline
Packaging: 10g
Price: $1100
Updated: 2021/12/16

Less

4-Aminoisoquinoline Chemical Properties,Usage,Production

Uses

4-Isoquinolylamine can be used for synthesis of Rho kinase inhibitors.

Synthesis Reference(s)

Journal of the American Chemical Society, 64, p. 783, 1942 DOI: 10.1021/ja01256a012

Synthesis

881668-81-1

23687-25-4

A mixture of N-benzyl-4-aminoisoquinoline (1.00 g, 4.27 mmol) was reacted with a mixture of acetic acid (30 mL) and H2SO4 (7.5 mL, concentration not specified) for 6 hours at 100 °C with stirring. Upon completion of the reaction, the mixture was cooled to room temperature and the reaction was quenched with saturated aqueous NaHCO3 solution. Subsequently, Na2CO3 (200 mL) was added and diluted with water, followed by extraction with EtOAc (5 x 25 mL). The organic phases were combined, concentrated and the residue was purified by chromatography (eluent: EtOAc) to afford the target compound 4-aminoisoquinoline (325 mg, 53% yield) as a yellow solid.1H NMR (DMSO-d6, 400 MHz) δ 8.49 (s, 1H), 8.10 (d, 1H), 7.90 (d, 1H), 7.87 (s, 1H ), 7.64-7.54 (m, 2H), 5.82 (s, 2H).

Solubility in organics

4-isoquinolamine (4-Aminoisoquinoline) is slightly soluble in water and more soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane.

References

[1] Patent: WO2006/32851, 2006, A1. Location in patent: Page/Page column 49

4-Aminoisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-Aminoisoquinoline Suppliers

Americas 1 Canada 1 China 188 Czech Republic 1 Europe 1 Germany 2 India 10 Japan 2 South Korea 1 Switzerland 2 The Netherlands 1 Ukraine 3 United Kingdom 10 United States 27 Global 250

Changzhou Langyi Biomedical Technology Co., Ltd.

Tel: 13706129682
Email: tiffany@langyupharm.com
Country: China
ProdList: 84
Advantage: 58

Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.

Tel: 0515-89701588 13770166955
Fax: 0515-87400189
Email: orgunion@orgunion.com
Country: China
ProdList: 620
Advantage: 55

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 2000
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9998
Advantage: 58

Henan Junyuejian Biotechnology Co., LTD

Tel: 1555-0142250 18661514130
Email: 1035729108@qq.com
Country: China
ProdList: 675
Advantage: 58

Changzhou Jiuwu Chemical co., Ltd.

Tel: 13775162768
Email: 16356194@qq.com
Country: China
ProdList: 31
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9309
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
Fax: +86 10 61256049
Email: sales@zeroschem.com
Country: China
ProdList: 1371
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

Suzhou Sibian Chemical Technology Co.,Ltd.

Tel: 0512-65617459 18915409046
Fax: 0512-65617459
Email: sales@sibian-chem.com
Country: China
ProdList: 1922
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Runpharm Technology Limited

Tel: 18171398856 2968382473
Fax: 0086-21-50758330
Email: service@runpharm.com
Country: China
ProdList: 716
Advantage: 55

Tianjin Chemlike Scientific Co., Ltd.

Tel: 022-27407596
Fax: 022-27407972
Email: sales@chemlike.com
Country: China
ProdList: 20
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

Beijing Universal Century Technology Co., Ltd.

Tel: 400-8706899
Fax: 400-8706899
Email: hysj_bj.com
Country: China
ProdList: 3583
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Sense Chemicals (Shanghai) Co., Ltd.

Tel: +86 13590492756
Fax: +86 (0)21 57626234
Email: michael.he@sensechemicals.com
Country: China
ProdList: 426
Advantage: 58

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3852
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Chongqing Xingcan Pharmaceutical Technology Co., Ltd.

Tel: 023-13650506873 19923294409
Email: xingcanyaoye@sina.com
Country: China
ProdList: 1604
Advantage: 58

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883
Fax: 0731-82251112
Email: sales@huatengsci.com
Country: China
ProdList: 5872
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: mafarm@126.com
Country: China
ProdList: 4542
Advantage: 58

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Shanghai Na Qian Chemical Technology Co. Ltd.

Tel: 13598610367
Fax: QQ:2468833170
Email: 2841375912@qq.com
Country: China
ProdList: 2789
Advantage: 52

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 16679
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4891
Advantage: 55

Nova(Shanghai) Pharmaceutical Co.,Ltd

Tel: 21-58226973 18917146209
Fax: +86-21-51685790
Email: Joseph@novapharmas.com
Country: China
ProdList: 476
Advantage: 55

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

Shanghai Uchem Inc.

Tel: 15618758386; 15618758386
Fax: QQ:3004479444
Email: sales3@myuchem.com
Country: China
ProdList: 1988
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Less

View Lastest Price from 4-Aminoisoquinoline manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Aminoisoquinoline 23687-25-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

Career Henan Chemical Co

Product: 4-Isoquinolylamine 23687-25-4
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

23687-25-4, 4-AminoisoquinolineRelated Search:

Sulfamic acid Isoquinoline Aminopyrine EC 2.6.1.2 Glucosamine Acetaminophen ISOQUINOLIN-3-AMINE 4-Isoquinolinamine,3-bromo-(9CI) ISOQUINOLIN-1-YLAMINE 4-NITROISOQUINOLINE 1-BUTYL-ISOQUINOLIN-3-YLAMINE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-7-YLAMINE ISOQUINOLIN-5-YLAMINE Isoquinolin-7-ylamine 5-Isoquinolinamine,7-chloro-(9CI) 6-BROMOISOQUINOLIN-1-YLAMINE ISOQUINOLIN-4-YLAMINE 3-CHLORO-4-ISOQUINOLINAMINE

Isoquinolin-4-ylamine

4-Aminoisoquinoline 97%

NSC 170840

Isoquinolin-4-amine, 4-Amino-2-azanaphthalene

ISOQUINOLIN-4-AMINE

4-isoquinolylamine

4-Aminoisoquinoline(WX609381)

4-ISOQUINOLINAMINE

4-AMINOISOQUINOLINE

isoqulinolin-4-amine

4-Aminoisoquinoline &gt

4-Isoquinolylamine ISO 9001：2015 REACH

4-Isoquinolinamine (9CI, ACI)

4-lsoquinolylamine

23687-25-4

Building Blocks

Isoquinoline

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Quinoline series

Amines

Quinolines, Isoquinolines & Quinoxalines