3-N-Butylphthalide

Product Name: 3-N-Butylphthalide
CAS No.: 6066-49-5
Chemical Name: 3-N-Butylphthalide
Synonyms: butylphthalide;3-Butylphthalide;3-n-Butylphathlide;3-Butylisobenzofuran-1(3H)-one;Butylphathlide;3-butyl-1(3H)-Isobenzofuranone;FEMA 3334;BUTYLPHTHALIDE, 3-n-(P);CL234;Butylphthalein
CBNumber: CB5174179
Molecular Formula: C12H14O2
Formula Weight: 190.24
MOL File: 6066-49-5.mol

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3-N-Butylphthalide Property

Boiling point:: 265.75°C (rough estimate)
Density: 1.0527 (rough estimate)
refractive index: 1.5197 (estimate)
FEMA: 3334 | 3-N-BUTYLPHTHALIDE
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Chloroform (Slightly), Methanol (Slightly); Almost insoluble in water, soluble in alcohol and oils.
form: Oil
color: Colourless to Yellow
Odor: at 10.00 % in dipropylene glycol. herbal phenolic celery
Odor Type: herbal
JECFA Number: 1169
Stability:: Hygroscopic
Major Application: metabolomics
vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions: PERFUMING
InChI: 1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3
InChIKey: HJXMNVQARNZTEE-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2C(CCCC)O1
LogP: 2.80
NIST Chemistry Reference: 3-Butylphthalide(6066-49-5)
EPA Substance Registry System: 1(3H)-Isobenzofuranone, 3-butyl- (6066-49-5)

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Safety

WGK Germany: WGK 3
TSCA: TSCA listed
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00312
Product name: 3-N-Butylphthalide
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $263
Updated: 2025/07/31

TCI Chemical

Product number: B6520
Product name: Butylphthalide
Purity: min. 98.0 %
Packaging: 1G
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: B6520
Product name: Butylphthalide
Purity: min. 98.0 %
Packaging: 5G
Price: $336
Updated: 2025/07/31

Cayman Chemical

Product number: 30284
Product name: (±)-Butylphthalide
Packaging: 500mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 30284
Product name: (±)-Butylphthalide
Packaging: 1g
Price: $121
Updated: 2024/03/01

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3-N-Butylphthalide Chemical Properties,Usage,Production

Chemical Properties

3-N-Butylphthalide has a warm, spicy herbaceous odor.

Occurrence

Reported found in Levisticum officinale (lovage) and L. acutilobum; also in celery oil.

Uses

3-Butylphthalide is a cardiovascular drug used for the treatment of cerebral ischemic stroke. This interesting Lactone finds use in the composing of meat flavors, spice blends, etc.

Preparation

From celery oil; from phthalide via bromination and subsequent reaction of the resulting phthalidic acid with n-butyl magnesium bromide.

Definition

ChEBI: Butylphthalide is a member of benzofurans.

Aroma threshold values

Detection: 5 ppb

Biological Activity

3-N-Butylphthalide (NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.[1]

References

[1] A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. DOI:10.1155/2016/5012341

3-N-Butylphthalide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-N-Butylphthalide Suppliers

China 338 Germany 1 India 2 United Kingdom 2 United States 18 USA 1 Global 362

Shijiazhuang Coshine Chemical Co.,Ltd

Tel: 18633820607 18633820607
Email: 377964081@qq.com
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ProdList: 94
Advantage: 58

Shijiazhuang Qiyue Chemical Co. LTD

Tel: 15369111890
Fax: 15369111890
Email: sjzqiyuekeji@163.com
Country: China
ProdList: 308
Advantage: 58

Allikang Pharmaceutical Co., LTD

Tel: 0573-87390950 13806705416
Email: wzj@alicornpharma.com
Country: China
ProdList: 57
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Nanjing Yikangda Pharmaceutical Technology Co.LTD

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Email: 753016615@qq.com
Country: China
ProdList: 498
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Shijiazhuang C-element Biotech Co.,Ltd

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Email: Lisa@C-elementBiotech.com
Country: China
ProdList: 159
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Chengdu Push Bio-Technology Co., Ltd.

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Email: 18080489829@163.com
Country: China
ProdList: 8314
Advantage: 60

Cangzhou Enke Pharma Tech Co.,ltd.

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Country: China
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J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
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Country: China
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Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
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Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9411
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Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11776
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View Lastest Price from 3-N-Butylphthalide manufacturers

Zhengzhou Anbu Chem Co.,Ltd

Product: 3-N-Butylphthalide 6066-49-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2025-07-30

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3-N-BUTYLPHTHALIDE 6066-49-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-13

Henan Aochuang Chemical Co.,Ltd.

Product: 3-N-BUTYLPHTHALIDE 6066-49-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-09

6066-49-5, 3-N-ButylphthalideRelated Search:

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6066-49-5