(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
- Product Name
- (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
- CAS No.
- 112068-01-6
- Chemical Name
- (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
- Synonyms
- (S)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(S)-DIPHENYLPROLINOL;SDPP;(S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL;ALPHA,ALPHA-DIPHENYL-L-PROLINOL;Diphenyl(2-pyrrolidinyl)methanol;(S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE;alpha,alpha-Diphenyl;Nebivolol Impurity 49;Dextrodiphenylprolinol
- CBNumber
- CB5178203
- Molecular Formula
- C17H19NO
- Formula Weight
- 253.34
- MOL File
- 112068-01-6.mol
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Property
- Melting point:
- 77-80 °C(lit.)
- alpha
- -59 º (c=3, methanol 25 ºC)
- Boiling point:
- 396.54°C (rough estimate)
- Density
- 1.0078 (rough estimate)
- refractive index
- -66.5 ° (C=3, CHCl3)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in chloroform.
- form
- powder
- pka
- 13.15±0.29(Predicted)
- color
- white to off white ., crystal
- optical activity
- [α]20/D 67°, c = 3 in chloroform
- Merck
- 14,155
- BRN
- 17103
- InChIKey
- OGCGXUGBDJGFFY-INIZCTEOSA-N
- CAS DataBase Reference
- 112068-01-6(CAS DataBase Reference)
- NIST Chemistry Reference
- S-(-)-1,1-diphenylprolinol(112068-01-6)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-24/25-36
- WGK Germany
- 3
- F
- 10-34
- TSCA
- No
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 368199
- Product name
- (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol
- Purity
- 99%
- Packaging
- 1g
- Price
- $15.6
- Updated
- 2024/03/01
- Product number
- 368199
- Product name
- (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol
- Purity
- 99%
- Packaging
- 5g
- Price
- $90.5
- Updated
- 2024/03/01
- Product number
- D2735
- Product name
- (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2024/03/01
- Product number
- D2735
- Product name
- (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $248
- Updated
- 2024/03/01
- Product number
- L09217
- Product name
- (S)-(-)-alpha,alpha-Diphenylprolinol
- Purity
- 98%
- Packaging
- 1g
- Price
- $82
- Updated
- 2023/06/20
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Usage,Production
Chemical Properties
white to beige crystals or crystalline powder
Uses
suzuki reaction
Uses
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.
Preparation
Into a four-necked flask, add tetrahydrofuran, L-proline methyl ester hydrochloride, and phenyl magnesium chloride (dissolved in tetrahydrofuran) solution was added dropwise from a constant pressure dropping funnel, and the addition was completed in about 4 hours, and then stirred at 10-15°C for 3 hours. Add water, adjust the pH to 5-6 with 10% ammonium chloride aqueous solution, extract with dichloromethane, extract the aqueous layer twice with dichloromethane each time, and obtain the organic phase. Wash once with saturated sodium chloride aqueous solution. The organic phase was dried with anhydrous sodium sulfate for 4 hours and filtered. The obtained organic phase was distilled under reduced pressure to distill dichloromethane and tetrahydrofuran to obtain light yellow oily (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, yield 86.6%.
Application
(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (DPPM) may be used in the following processes:
- DPPM reacts with catecholborane to form a spiroborate ester, which can be an efficient catalyst for the synthesis of enantiopure alcohols by borane reduction of acetophenone.
- The catalyst generated in situ by reacting DPPM with borane-diethylaniline, can efficiently catalyze the enantioselective reduction of 2′-fluoroacetophenone.
- Mesoporous SBA-15 silica functionalized with DPPM can catalyze the addition of diethylzinc to benzaldehyde to form (S)-1-phenyl-propanol.
General Description
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is a bifunctional organocatalyst.
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Suppliers
- Tel
- --
- Fax
- --
- spectrum@kv.ukrtel.net
- Country
- Ukraine
- ProdList
- 2741
- Advantage
- 53
View Lastest Price from (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol manufacturers
- Product
- (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol 112068-01-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29
- Product
- Dapoxetine Impurity 72 112068-01-6
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-05-21
- Product
- (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol 112068-01-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-16