(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Product Name: (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
CAS No.: 22348-32-9
Chemical Name: (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
Synonyms: RDPP;(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(R)-DIPHENYLPROLINOL;PYRROLIDINEMETHANOL;idinemethanoL;(R)-(+)-2-(Diphenylh;(R)-(+)-α,α-DiphenyL;Nebivolol Impurity 48;(R)-1-DIPHENYL-PROLINOL;A,A-DIPHENYL-D-PROLINOL
CBNumber: CB1101689
Molecular Formula: C17H19NO
Formula Weight: 253.35
MOL File: 22348-32-9.mol

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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Property

Melting point:: 77-80 °C
alpha: 59 º (589nm, c=3, MeOH 25 ºC)
Boiling point:: 396.54°C (rough estimate)
Density: 1.0078 (rough estimate)
refractive index: 58 ° (C=2, MeOH)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: almost transparency in Chloroform
form: solid
pka: 13.15±0.29(Predicted)
color: white to off-white
optical activity: [α]20/D +69°, c = 3 in chloroform
BRN: 4353363
InChIKey: OGCGXUGBDJGFFY-MRXNPFEDSA-N
CAS DataBase Reference: 22348-32-9(CAS DataBase Reference)
NIST Chemistry Reference: (R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 10-34
TSCA: No
HS Code: 29221990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 382337
Product name: (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity: 98%
Packaging: 1g
Price: $153.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 382337
Product name: (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity: 98%
Packaging: 5g
Price: $208
Updated: 2024/03/01

TCI Chemical

Product number: D2365
Product name: (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $131
Updated: 2024/03/01

TCI Chemical

Product number: D2365
Product name: (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $453
Updated: 2024/03/01

Alfa Aesar

Product number: L09218
Product name: (R)-(+)-alpha,alpha-Diphenylprolinol
Purity: 99%
Packaging: 1g
Price: $148
Updated: 2023/06/20

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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to faintly yellow crystalline powder

Uses

suzuki reaction

Uses

Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Definition

ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane.

Synthesis

Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Suppliers

Americas 1 Belgium 5 Canada 1 China 372 China Hong Kong 1 Europe 4 France 3 Germany 5 India 22 Ireland 1 Italy 1 Japan 3 Switzerland 3 United Kingdom 13 United States 62 Global 498

Shanghai Forxine Pharmaceutical Co., Ltd.

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JIANGXI AIFEIMU TECHNOLOGY CO.,LTD

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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View Lastest Price from (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price: US $32.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-15

Hebei Weibang Biotechnology Co., Ltd

Product: (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-29

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-19

22348-32-9, (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanolRelated Search:

Diethylstilbestrol Biphenyl Fosfomycin tromethamine Ketorolac tromethamine (R)-TERT-LEUCINOL Pyrrolidine Dexketoprofen trometamol TRISTEARIN (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-alpha,alpha-Diphenylmethylprolinol (R)-O-TOLYL-CBS-OXAZABOROLIDINE, 0.5M I& (R)-DI-2-NAPHTHYLPROLINOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol D(-)Prolinol (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol (R)-A,A-BIS(3,5-DICHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL (R,R)-(-)-2,6-BIS[2-(HYDROXYDIPHENYLMETHYL)-1-PYRROLIDINYL-METHYL]-4-METHYLPHENOL

2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-

diphenyl-[(2R)-pyrrolidin-2-yl]methanol

2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-

(2R)-α,α-diphenyl-2-Pyrrolidinemethanol

(R)-1-DIPHENYL-PROLINOL

(R)-(+)-2-(DIPHENYLHYDROXYMETHYL)-PYRROLIDIN

(R)-(+)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE

(R)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE

(R)-(+)-ɑ,ɑ-Diphenylprolinol, 99%

ALPHA,ALPHA-DIPHENYL-D-PROLINOL

A,A-DIPHENYL-D-PROLINOL

alpha,alpha-diphenyl-2-pyrrolidinemethanol

(R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine

α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine

(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol,98%

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol ,98%

α,α-Diphenyl-D-prolinol,(R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol,α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine

(2R)-(+)-2-[Hydroxy(diphenyl)methyl]pyrrolidine

(R)-(+)-2-(Diphenylh

alpha-Diphenyl-2-pyrrolidineMethanol

Diphenyl[(2R)-(+)-pyrrolidin-2-yl]methanol, (R)-(+)-alpha,alpha-Diphenylprolinol

alpha,alpha-Diphenyl-D-prolinol (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine

-(+)-2-(DiphenylhydroxyMethyl)pyrrolidine

(R)-(+)-α,α-DiphenyL

idinemethanoL

R(+)-A,A-DIPHENYLPROLINOL

R-(+)-ALFA,ALFA-DIPHENYL-2-PYRROLIDINE METHANOL

(R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL

(R)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL

(R)-(+)-ALPHA,ALPHA-DIPHENYL-(2-PYRROLIDINYL)-METHANOL

(R)-(+)-ALPHA,ALPHA-DIPHENYLPROLINOL

(R)-(+)-DIPHENYL-2-PYRROLIDINEMETHANOL

(R)-DIPHENYLPROLINOL

(R)-(+)-DIPHENYLPYRROLIDINEMETHANOL

RDPP

?-DIPHENYL(PYRROLIDIN-2-YL)METHANOL

(R)-(+)-A,A-DIPHENYL-2-PYRROLIDINEMETHANOL

(r)-(+)-à,à-diphenyl-2-pyrrolidinemethanol

(r)-(+)-à,à-diphenylprolinol

α,α-diphenyl-d-prolinol

2,2-DIPHENYL-(2R)-2-PYRROLIDINEMETHANOL

PYRROLIDINEMETHANOL

(R)-(+)-alpha,alpha-diphenyl-2-pyrrolidine

(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL

(R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PRRROLIDINE METHANOL 99.0+%

(+)-Diphenyl[(2R)-pyrrolidin-2-yl]methanol, (+)-alpha,alpha-Diphenyl-D-prolinol

(R)-(+)- alpha,alpha-Diphenyl-2-yrrolidine Methanol

-DIPHENYL(PYRROLIDIN-2-YL)METHANOL

(R)-(+)-alpha,alpha-Diphenyl-2-Pymolidinemethanol

(R)-(+)-α,α-Diphenyl-2-pyrrolidineMethanol 98%

2-PyrrolidineMethanol,a,a-diphenyl-, (2R)-

(R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-D-prolinol

2-Pyrrolidinemethanol, .alpha.,.alpha.-diphenyl-, (2R)-

(<i>R</i>)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol

(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 98%

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol, >=99%

(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol&gt