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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Product Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
CAS No.
22348-32-9
Chemical Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
Synonyms
RDPP;(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(R)-DIPHENYLPROLINOL;PYRROLIDINEMETHANOL;(R)-D2PM;idinemethanoL;(R)-(+)-2-(Diphenylh;(R)-(+)-α,α-DiphenyL;Nebivolol Impurity 48;(R)-1-DIPHENYL-PROLINOL
CBNumber
CB1101689
Molecular Formula
C17H19NO
Formula Weight
253.35
MOL File
22348-32-9.mol
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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Property

Melting point:
77-80 °C
alpha 
59 º (589nm, c=3, MeOH 25 ºC)
Boiling point:
396.54°C (rough estimate)
Density 
1.0078 (rough estimate)
refractive index 
58 ° (C=2, MeOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
almost transparency in Chloroform
form 
solid
pka
13.15±0.29(Predicted)
color 
white to off-white
optical activity
[α]20/D +69°, c = 3 in chloroform
BRN 
4353363
InChI
1S/C17H19NO/c19-17(16-12-7-13-18-16,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16,18-19H,7,12-13H2/t16-/m1/s1
InChIKey
OGCGXUGBDJGFFY-MRXNPFEDSA-N
SMILES
OC([C@H]1CCCN1)(c2ccccc2)c3ccccc3
CAS DataBase Reference
22348-32-9(CAS DataBase Reference)
NIST Chemistry Reference
(R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
10-34
TSCA 
No
HS Code 
29221990
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
5g
Price
$268
Updated
2025/07/31
Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
1g
Price
$277.2
Updated
2025/07/31
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$118
Updated
2025/07/31
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$408
Updated
2025/07/31
Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
100mg
Price
$141
Updated
2023/01/07
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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to faintly yellow crystalline powder

Uses

suzuki reaction

Uses

Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Definition

ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane.

Synthesis

Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Suppliers

Americas 1 Belgium 5 Canada 1 China 375 China Hong Kong 1 Europe 4 France 3 Germany 5 India 22 Ireland 1 Italy 1 Japan 3 Switzerland 3 United Kingdom 13 United States 62 Global 501
Shanghai Forxine Pharmaceutical Co., Ltd.
Tel
21-21-64961388 18918697718
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6496-1388-8320
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service@forxine.com
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China
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China Synchem Technology Co.,Ltd.
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+86-0552-4929304 +86-18055277008
Fax
+86-552-4928800
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sales@cnsynchem.com
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China
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Viwit Pharmaceutical Co., Ltd.
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0632-0632-2980981 15063270987
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0632-2989678
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service.china3@viwit.com
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China
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Hubei Xinkang Pharmaceutical Chemical Co., Ltd
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027-027-59308705 18871579363
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027-59308705
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1248680011@qq.com
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J & K SCIENTIFIC LTD.
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86-10-82849933
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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4006356688 18621169109
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86-21-61259102
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market03@meryer.com
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China
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INTATRADE GmbH
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+49 3493/605464
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+49 3493/605470
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sales@intatrade.de
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Germany
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JIANGXI AIFEIMU TECHNOLOGY CO.,LTD
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793-33899567 13735087952
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+86-570-6259526
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sales@afmpharm.com
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China
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
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saleschina@alfa-asia.com
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China
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30123
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
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Sales-CN@TCIchemicals.com
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China
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View Lastest Price from (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol manufacturers

Hangzhou Verychem Science And Technology Co.Ltd
Product
2,2-diphenyl-(2R)-2-pyrrolidinemethanol 22348-32-9
Price
US $0.00-0.00/kg
Min. Order
10kg
Purity
99%min
Supply Ability
1 tons
Release date
2025-09-23
Hebei Chuanghai Biotechnology Co., Ltd
Product
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-15

22348-32-9, (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanolRelated Search:

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  • ALPHA,ALPHA-DIPHENYL-D-PROLINOL
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  • alpha,alpha-diphenyl-2-pyrrolidinemethanol
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  • α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
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  • (2R)-(+)-2-[Hydroxy(diphenyl)methyl]pyrrolidine
  • (R)-(+)-2-(Diphenylh
  • alpha-Diphenyl-2-pyrrolidineMethanol
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  • (+)-Diphenyl[(2R)-pyrrolidin-2-yl]methanol, (+)-alpha,alpha-Diphenyl-D-prolinol
  • (R)-(+)- alpha,alpha-Diphenyl-2-yrrolidine Methanol
  • -DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-alpha,alpha-Diphenyl-2-Pymolidinemethanol
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidineMethanol 98%
  • 2-PyrrolidineMethanol,a,a-diphenyl-, (2R)-
  • (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-D-prolinol
  • 2-Pyrrolidinemethanol, .alpha.,.alpha.-diphenyl-, (2R)-
  • (<i>R</i>)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
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