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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Product Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
CAS No.
22348-32-9
Chemical Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
Synonyms
RDPP;(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(R)-DIPHENYLPROLINOL;PYRROLIDINEMETHANOL;idinemethanoL;(R)-(+)-2-(Diphenylh;(R)-(+)-α,α-DiphenyL;Nebivolol Impurity 48;(R)-1-DIPHENYL-PROLINOL;A,A-DIPHENYL-D-PROLINOL
CBNumber
CB1101689
Molecular Formula
C17H19NO
Formula Weight
253.35
MOL File
22348-32-9.mol
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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Property

Melting point:
77-80 °C
alpha 
59 º (589nm, c=3, MeOH 25 ºC)
Boiling point:
396.54°C (rough estimate)
Density 
1.0078 (rough estimate)
refractive index 
58 ° (C=2, MeOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
almost transparency in Chloroform
form 
solid
pka
13.15±0.29(Predicted)
color 
white to off-white
optical activity
[α]20/D +69°, c = 3 in chloroform
BRN 
4353363
InChIKey
OGCGXUGBDJGFFY-MRXNPFEDSA-N
CAS DataBase Reference
22348-32-9(CAS DataBase Reference)
NIST Chemistry Reference
(R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
10-34
TSCA 
No
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
1g
Price
$153.6
Updated
2024/03/01
Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
5g
Price
$208
Updated
2024/03/01
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$131
Updated
2024/03/01
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$453
Updated
2024/03/01
Alfa Aesar
Product number
L09218
Product name
(R)-(+)-alpha,alpha-Diphenylprolinol
Purity
99%
Packaging
1g
Price
$148
Updated
2023/06/20
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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to faintly yellow crystalline powder

Uses

suzuki reaction

Uses

Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Definition

ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane.

Synthesis

Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Suppliers

Americas 1 Belgium 5 Canada 1 China 373 China Hong Kong 1 Europe 4 France 3 Germany 5 India 22 Ireland 1 Italy 1 Japan 3 Switzerland 3 United Kingdom 13 United States 62 Global 499
Chemgo SARL
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sales.contact@chemgo.fr
Country
France
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Interchim SA
Tel
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Fax
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him@interchim.com
Country
France
ProdList
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Interchim S.A.
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interchim@interchim.com
Country
France
ProdList
6302
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76
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View Lastest Price from (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-15
Hebei Weibang Biotechnology Co., Ltd
Product
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-19

22348-32-9, (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanolRelated Search:

Diethylstilbestrol Biphenyl Fosfomycin tromethamine Ketorolac tromethamine (R)-TERT-LEUCINOL Pyrrolidine Dexketoprofen trometamol TRISTEARIN (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-alpha,alpha-Diphenylmethylprolinol (R)-O-TOLYL-CBS-OXAZABOROLIDINE, 0.5M I& (R)-DI-2-NAPHTHYLPROLINOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol D(-)Prolinol (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol (R)-A,A-BIS(3,5-DICHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL (R,R)-(-)-2,6-BIS[2-(HYDROXYDIPHENYLMETHYL)-1-PYRROLIDINYL-METHYL]-4-METHYLPHENOL

  • 2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-
  • diphenyl-[(2R)-pyrrolidin-2-yl]methanol
  • 2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-
  • (2R)-α,α-diphenyl-2-Pyrrolidinemethanol
  • (R)-1-DIPHENYL-PROLINOL
  • (R)-(+)-2-(DIPHENYLHYDROXYMETHYL)-PYRROLIDIN
  • (R)-(+)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
  • (R)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
  • (R)-(+)-ɑ,ɑ-Diphenylprolinol, 99%
  • ALPHA,ALPHA-DIPHENYL-D-PROLINOL
  • A,A-DIPHENYL-D-PROLINOL
  • alpha,alpha-diphenyl-2-pyrrolidinemethanol
  • (R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol,98%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol ,98%
  • α,α-Diphenyl-D-prolinol,(R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol,α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (2R)-(+)-2-[Hydroxy(diphenyl)methyl]pyrrolidine
  • (R)-(+)-2-(Diphenylh
  • alpha-Diphenyl-2-pyrrolidineMethanol
  • Diphenyl[(2R)-(+)-pyrrolidin-2-yl]methanol, (R)-(+)-alpha,alpha-Diphenylprolinol
  • alpha,alpha-Diphenyl-D-prolinol (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine
  • -(+)-2-(DiphenylhydroxyMethyl)pyrrolidine
  • (R)-(+)-α,α-DiphenyL
  • idinemethanoL
  • R(+)-A,A-DIPHENYLPROLINOL
  • R-(+)-ALFA,ALFA-DIPHENYL-2-PYRROLIDINE METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-(2-PYRROLIDINYL)-METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYLPROLINOL
  • (R)-(+)-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-DIPHENYLPROLINOL
  • (R)-(+)-DIPHENYLPYRROLIDINEMETHANOL
  • RDPP
  • ?-DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-A,A-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (r)-(+)-à,à-diphenyl-2-pyrrolidinemethanol
  • (r)-(+)-à,à-diphenylprolinol
  • α,α-diphenyl-d-prolinol
  • 2,2-DIPHENYL-(2R)-2-PYRROLIDINEMETHANOL
  • PYRROLIDINEMETHANOL
  • (R)-(+)-alpha,alpha-diphenyl-2-pyrrolidine
  • (R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PRRROLIDINE METHANOL 99.0+%
  • (+)-Diphenyl[(2R)-pyrrolidin-2-yl]methanol, (+)-alpha,alpha-Diphenyl-D-prolinol
  • (R)-(+)- alpha,alpha-Diphenyl-2-yrrolidine Methanol
  • -DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-alpha,alpha-Diphenyl-2-Pymolidinemethanol
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidineMethanol 98%
  • 2-PyrrolidineMethanol,a,a-diphenyl-, (2R)-
  • (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-D-prolinol
  • 2-Pyrrolidinemethanol, .alpha.,.alpha.-diphenyl-, (2R)-
  • (<i>R</i>)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
  • (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 98%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol, >=99%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol&gt