ChemicalBook > CAS DataBase List > (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol

Product Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
CAS No.
22348-32-9
Chemical Name
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol
Synonyms
RDPP;(R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(R)-DIPHENYLPROLINOL;PYRROLIDINEMETHANOL;idinemethanoL;(R)-(+)-2-(Diphenylh;(R)-(+)-α,α-DiphenyL;Nebivolol Impurity 48;(R)-1-DIPHENYL-PROLINOL;A,A-DIPHENYL-D-PROLINOL
CBNumber
CB1101689
Molecular Formula
C17H19NO
Formula Weight
253.35
MOL File
22348-32-9.mol
More
Less

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Property

Melting point:
77-80 °C
alpha 
59 º (589nm, c=3, MeOH 25 ºC)
Boiling point:
396.54°C (rough estimate)
Density 
1.0078 (rough estimate)
refractive index 
58 ° (C=2, MeOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
almost transparency in Chloroform
form 
solid
pka
13.15±0.29(Predicted)
color 
white to off-white
optical activity
[α]20/D +69°, c = 3 in chloroform
BRN 
4353363
InChIKey
OGCGXUGBDJGFFY-MRXNPFEDSA-N
CAS DataBase Reference
22348-32-9(CAS DataBase Reference)
NIST Chemistry Reference
(R)-alpha-(2-pyrrolidinyl)benzhydryl alcohol(22348-32-9)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
F 
10-34
TSCA 
No
HS Code 
29221990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
1g
Price
$153.6
Updated
2024/03/01
Sigma-Aldrich
Product number
382337
Product name
(R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
Purity
98%
Packaging
5g
Price
$208
Updated
2024/03/01
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$131
Updated
2024/03/01
TCI Chemical
Product number
D2365
Product name
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$453
Updated
2024/03/01
Alfa Aesar
Product number
L09218
Product name
(R)-(+)-alpha,alpha-Diphenylprolinol
Purity
99%
Packaging
1g
Price
$148
Updated
2023/06/20
More
Less

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Usage,Production

Chemical Properties

white to faintly yellow crystalline powder

Uses

suzuki reaction

Uses

Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Definition

ChEBI: (r)-alpha,alpha-diphenyl-2-pyrrolidinemethanol is a diarylmethane.

Synthesis

Draw 14 kg of tetrahydrofuran into the reaction kettle. 61.5 kg of a 34% strength solution of phenylmagnesium chloride in tetrahydrofuran was added to the reaction vessel to initiate agitation and cooling cycles. The control temperature is 10 to 60 °C. The dropping time was controlled for 5 to 6 hours, and stirring was continued for 1 hour. Pump 24 kg of concentrated hydrochloric acid (mass concentration 36%) into the matching drip tank of the reaction kettle. constantly dropping, the dropping time is controlled for 1 hour, and the dropping process control temperature does not exceed 45 ° C. After the addition was completed, stirring was continued for 8 hours.Cool down to -5 ° C ~ 5 ° C to obtain (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol, a total of 17.2 kg, yield 85%.

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol Suppliers

Americas 1 Belgium 5 Canada 1 China 373 China Hong Kong 1 Europe 4 France 3 Germany 5 India 22 Ireland 1 Italy 1 Japan 3 Switzerland 3 United Kingdom 13 United States 62 Global 499
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47
Camida
Tel
--
Fax
--
Email
info@camida.com
Country
Europe
ProdList
3704
Advantage
71
More
Less

View Lastest Price from (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $32.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-15
Hebei Weibang Biotechnology Co., Ltd
Product
(R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-29
Hebei Chuanghai Biotechnology Co,.LTD
Product
(R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol 22348-32-9
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-19

22348-32-9, (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanolRelated Search:

Diethylstilbestrol Biphenyl Fosfomycin tromethamine Ketorolac tromethamine (R)-TERT-LEUCINOL Pyrrolidine Dexketoprofen trometamol TRISTEARIN (S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-alpha,alpha-Diphenylmethylprolinol (R)-O-TOLYL-CBS-OXAZABOROLIDINE, 0.5M I& (R)-DI-2-NAPHTHYLPROLINOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol D(-)Prolinol (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol (R)-A,A-BIS(3,5-DICHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE BIS(P-CHLOROPHENYL)-(2R)PYRROLIDINE METHANOL (R,R)-(-)-2,6-BIS[2-(HYDROXYDIPHENYLMETHYL)-1-PYRROLIDINYL-METHYL]-4-METHYLPHENOL

  • 2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-
  • diphenyl-[(2R)-pyrrolidin-2-yl]methanol
  • 2-Pyrrolidinemethanol, α,α-diphenyl-, (2R)-
  • (2R)-α,α-diphenyl-2-Pyrrolidinemethanol
  • (R)-1-DIPHENYL-PROLINOL
  • (R)-(+)-2-(DIPHENYLHYDROXYMETHYL)-PYRROLIDIN
  • (R)-(+)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
  • (R)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE
  • (R)-(+)-ɑ,ɑ-Diphenylprolinol, 99%
  • ALPHA,ALPHA-DIPHENYL-D-PROLINOL
  • A,A-DIPHENYL-D-PROLINOL
  • alpha,alpha-diphenyl-2-pyrrolidinemethanol
  • (R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol,98%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol ,98%
  • α,α-Diphenyl-D-prolinol,(R)-α,α-Diphenyl-2-pyrrolidinemethanol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol,α,α-Diphenyl-D-prolinol, (R)-2-(Diphenylhydroxymethyl)pyrrolidine
  • (2R)-(+)-2-[Hydroxy(diphenyl)methyl]pyrrolidine
  • (R)-(+)-2-(Diphenylh
  • alpha-Diphenyl-2-pyrrolidineMethanol
  • Diphenyl[(2R)-(+)-pyrrolidin-2-yl]methanol, (R)-(+)-alpha,alpha-Diphenylprolinol
  • alpha,alpha-Diphenyl-D-prolinol (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine
  • -(+)-2-(DiphenylhydroxyMethyl)pyrrolidine
  • (R)-(+)-α,α-DiphenyL
  • idinemethanoL
  • R(+)-A,A-DIPHENYLPROLINOL
  • R-(+)-ALFA,ALFA-DIPHENYL-2-PYRROLIDINE METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-(2-PYRROLIDINYL)-METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYLPROLINOL
  • (R)-(+)-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (R)-DIPHENYLPROLINOL
  • (R)-(+)-DIPHENYLPYRROLIDINEMETHANOL
  • RDPP
  • ?-DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-A,A-DIPHENYL-2-PYRROLIDINEMETHANOL
  • (r)-(+)-à,à-diphenyl-2-pyrrolidinemethanol
  • (r)-(+)-à,à-diphenylprolinol
  • α,α-diphenyl-d-prolinol
  • 2,2-DIPHENYL-(2R)-2-PYRROLIDINEMETHANOL
  • PYRROLIDINEMETHANOL
  • (R)-(+)-alpha,alpha-diphenyl-2-pyrrolidine
  • (R)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-ALPHA,ALPHA-DIPHENYL-2-PRRROLIDINE METHANOL 99.0+%
  • (+)-Diphenyl[(2R)-pyrrolidin-2-yl]methanol, (+)-alpha,alpha-Diphenyl-D-prolinol
  • (R)-(+)- alpha,alpha-Diphenyl-2-yrrolidine Methanol
  • -DIPHENYL(PYRROLIDIN-2-YL)METHANOL
  • (R)-(+)-alpha,alpha-Diphenyl-2-Pymolidinemethanol
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidineMethanol 98%
  • 2-PyrrolidineMethanol,a,a-diphenyl-, (2R)-
  • (R)-(+)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-D-prolinol
  • 2-Pyrrolidinemethanol, .alpha.,.alpha.-diphenyl-, (2R)-
  • (<i>R</i>)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
  • (R)-(+)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol 98%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol, >=99%
  • (R)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol&gt