(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL

Product Name: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL
CAS No.: 78603-93-7
Chemical Name: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL
Synonyms: (R)-2-Amino-1,1-diphenylpropan-1-ol;(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL;(R)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(2R)-2-amino-1,1-diphenylpropan-1-ol;(R)-(+)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(R)-(-)-2-AMINO-1,1-DIPHENYL-1-PROPANOL;(R)-2-Amino-1,1-diphenyl-1-propanol,98%e.e.;(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL USP/EP/BP;(R)-(+)-2-Amino-1,1-diphenyl-1-propanol;Benzenemethanol, α-[(1R)-1-aminoethyl]-α-phenyl-
CBNumber: CB5194418
Molecular Formula: C15H17NO
Formula Weight: 227.3
MOL File: 78603-93-7.mol

More

Less

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL Property

Melting point:: 102-105 °C(lit.)
Boiling point:: 407.8±40.0 °C(Predicted)
Density: 1.112±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 11.25±0.50(Predicted)
Appearance: Off-white to light yellow Solid
optical activity: [α]20/D +90°, c = 1 in chloroform
Sensitive: Air Sensitive
BRN: 3202230
CAS DataBase Reference: 78603-93-7(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: 8
HS Code: 2922190090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 549460
Product name: (R)-(+)-2-Amino-1,1-diphenyl-1-propanol
Purity: 99%
Packaging: 1g
Price: $166
Updated: 2023/06/20

TRC

Product number: A639768
Product name: (R)-2-Amino-1,1-diphenyl-1-propanol
Packaging: 1g
Price: $350
Updated: 2021/12/16

TRC

Product number: A639768
Product name: (R)-2-Amino-1,1-diphenyl-1-propanol
Packaging: 100mg
Price: $65
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-1-RA
Product name: (R)-(-)-2-Amino-1,1-diphenyl-1-propanol
Packaging: 1g
Price: $180
Updated: 2021/12/16

Apolloscientific

Product number: OR304003
Product name: (R)-(-)-2-Amino-1,1-diphenyl-1-propanol
Packaging: 5g
Price: $544
Updated: 2021/12/16

More

Less

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Synthesis

14316-06-4

100-58-3

78603-93-7

Example 5: Synthesis of (R)-2-Amino-1,1-diphenyl-propan-1-ol: A solution of phenylmagnesium bromide (PhMgBr, 0.87 mol, dissolved in 287 mL of tetrahydrofuran (THF)) was cooled to 0°C under inert atmosphere. Subsequently, D-alanine methyl ester hydrochloride ((R)-1-methoxycarbonyl-ethyl-ammonium chloride, 20 g, 140 mmol) was added in batches over 90 min, keeping the reaction temperature between 0-5 °C. After addition, the reaction mixture was continued to be stirred at 0-5 °C for 30 min and then slowly warmed up to room temperature. After the reaction was carried out at room temperature for 4 h, it was cooled to 0 °C again. A 10% w/w aqueous hydrochloric acid solution (100 mL) was slowly added at 0-5 °C for 60 min. After addition, the mixture was warmed up to room temperature. Next, ethyl acetate (300 mL) and water (400 mL) were added for extraction. After separating the organic and aqueous phases, the aqueous phase was extracted once more with ethyl acetate (200 mL). All organic phases were combined and washed sequentially with water (50 mL) and brine (50 mL). The organic phase was concentrated under vacuum to give about 50 g of residue. Hexane (30 mL) was slowly added to the residue over 30 minutes. The mixture was cooled to 0 °C over a period of 3 hours and aged at 0 °C for 1 hour. Finally, the mixture was filtered, isolated and dried to give (R)-2-amino-1,1-diphenyl-propan-1-ol (30.4 g, 80% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, CDCl3), δ 7.64 (dd, J = 7.6, 4.0 Hz, 2H), 7.51 (dd, J = 7.6, 1.4 Hz, 2H), 7.37-7.28 (m, 4H), 7.24-7.17 (m, 2H), 4.18 (q, J = 6.3 Hz, 1H), 0.99 ( d, J = 6.3 Hz, 3H).

References

[1] Patent: WO2012/79235, 2012, A1. Location in patent: Page/Page column 37-38
[2] Patent: WO2012/97511, 2012, A1. Location in patent: Page/Page column 62
[3] Patent: WO2012/97510, 2012, A1. Location in patent: Page/Page column 61

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL Suppliers

China 61 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 6 United States 18 Global 90

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Tianjin Derchemist Science & Technology Co., Ltd.

Tel: 22-58627059 13920586291
Fax: 022-58620305
Email: zdcomcon@126.com
Country: China
ProdList: 3829
Advantage: 50

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

Shijiazhuang Lickon PharmaTech Co., Ltd.

Tel: 031185291771 13832391721
Fax: 0311-67305698
Email: yaofeng2005@163.com
Country: China
ProdList: 978
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Chiral bio-compound co., Ltd.

Tel: 021-5068 3667/17749785980/1029026415; 17749785980
Fax: 021-50683667
Email: 1029026415@qq.com
Country: China
ProdList: 3397
Advantage: 58

More

Less

View Lastest Price from (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL manufacturers

Career Henan Chemical Co

Product: (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL 78603-93-7
Price: US $2.00/KG
Min. Order: 1g
Purity: 98%min
Supply Ability: ask
Release date: 2020-01-14

78603-93-7, (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOLRelated Search:

(S)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole (R)-4,5,5-TRIPHENYL-2-OXAZOLIDINONE (R)-(+)-a,a-Diphenyl-2-pyrrolidinemethanol (R)-(+)-5,5-DIPHENYL-4-BENZYL-2-OXAZOLIDINONE (R)-(+)-2-AMINO-3-METHYL-1,1-DIPHENYL-1-BUTANOL (R)-DI-2-NAPHTHYLPROLINOL (R)-2-Amino-3-methyl-1,1-diphenyl-1-butanol (R)-alpha,alpha-Diphenylmethylprolinol (R)-(+)-2-AMINO-4-METHYL-1,1-DIPHENYL-1-PENTANOL (R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL (R)-(+)-4-ISOPROPYL-5,5-DIPHENYL-2-OXAZOLIDINONE (S)-(-)-2-AMINO-1,1-DIPHENYL-1-PROPANOL,(S)-2-AMINO-1,1-DIPHENYL-1-PROPANOL,(S)-2-AMINO-1,2-DIPHENYL-1-PROPANOL (R)-(+)-5,5-DIPHENYL-4-ISOBUTYL-2-OXAZOLIDINONE (R)-(+)-N-CARBOMETHOXY-2-AMINO-1,1,2-TRIPHENYLETHANOL (R)-(+)-5,5-DIPHENYL-4-METHYL-2-OXAZOLIDINONE (R)-(+)-2-AMINO-1,1,3-TRIPHENYL-1-PROPANOL (R)-A,A-BIS(3,5-DICHLOROPHENYL)-2-PYRROLIDINEMETHANOL HYDROCHLORIDE (R)-2-(+)-AMINO-1,1,2-TRIPHENYLETHANOL

(R)-(-)-2-AMINO-1,1-DIPHENYL-1-PROPANOL

(R)-(+)-2-AMINO-1,1-DIPHENYL-1-PROPANOL

(R)-2-AMINO-1,1-DIPHENYL-1-PROPANOL

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL

(R)-2-Amino-1,1-diphenylpropan-1-ol

(R)-2-Amino-1,1-diphenyl-1-propanol,98%e.e.

(2R)-2-amino-1,1-diphenylpropan-1-ol

Benzenemethanol, α-[(1R)-1-aminoethyl]-α-phenyl-

(R)-2-AMINO-1,2-DIPHENYL-1-PROPANOL USP/EP/BP

(<i>R</i>)-(+)-2-Amino-1,1-diphenyl-1-propanol

78603-93-7

Organic Building Blocks

Chiral Building Blocks

Asymmetric Synthesis

Amino Alcohols

chiral

Amino Alcohols

Chiral Building Blocks

Organic Building Blocks