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HOMOGENTISIC ACID

Product Name
HOMOGENTISIC ACID
CAS No.
451-13-8
Chemical Name
HOMOGENTISIC ACID
Synonyms
2-(2,5-dihydroxyphenyl)acetic acid;alcapton;Melanic acid;homogentisicaci;HOMOGENTISIC ACID;Homogentisinic acid;HOMOGENTISIC ACID(RG);Homogentisic Acid >Homogentisic Acid, ≥ 97.0%;homogentisic acid free acid
CBNumber
CB5207860
Molecular Formula
C8H8O4
Formula Weight
168.15
MOL File
451-13-8.mol
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HOMOGENTISIC ACID Property

Melting point:
150-152 °C (lit.)
Boiling point:
257.07°C (rough estimate)
Density 
1.3037 (rough estimate)
refractive index 
1.5090 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in methanol.
pka
4.4(at 25℃)
form 
crystalline
color 
off-white to tan
Water Solubility 
very faint turbidity
Merck 
14,4737
BRN 
2692860
LogP
0.860
CAS DataBase Reference
451-13-8(CAS DataBase Reference)
EPA Substance Registry System
Benzeneacetic acid, 2,5-dihydroxy- (451-13-8)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AH0589000
TSCA 
Yes
HS Code 
29182900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H0751
Product name
Homogentisic acid
Purity
crystalline
Packaging
100mg
Price
$140
Updated
2024/03/01
Sigma-Aldrich
Product number
H0751
Product name
Homogentisic acid
Purity
crystalline
Packaging
500mg
Price
$351
Updated
2024/03/01
Sigma-Aldrich
Product number
92168
Product name
Homogentisic acid
Purity
analytical standard
Packaging
25MG
Price
$126
Updated
2022/05/15
TCI Chemical
Product number
D1050
Product name
Homogentisic Acid
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$287
Updated
2024/03/01
TCI Chemical
Product number
D1050
Product name
Homogentisic Acid
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$923
Updated
2024/03/01
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HOMOGENTISIC ACID Chemical Properties,Usage,Production

Chemical Properties

off-white to tan crystals or crystalline powder

Uses

An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.

Uses

Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:

  • Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
  • Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).

It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).

Definition

ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.

General Description

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.

Purification Methods

Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]

HOMOGENTISIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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HOMOGENTISIC ACID Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
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View Lastest Price from HOMOGENTISIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
HOMOGENTISIC ACID 451-13-8
Price
US $25.00-12.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-05
Career Henan Chemical Co
Product
HOMOGENTISIC ACID 451-13-8
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-12

451-13-8, HOMOGENTISIC ACIDRelated Search:


  • (2,5-dihydroxyphenyl)-aceticaci
  • 2,5-dihydroxy-benzeneaceticaci
  • 2,5-dihydroxybenzeneaceticacid
  • 2-(2,5-dihydroxyphenyl)acetate
  • alcapton
  • Homogentisic acid 2,5-Dihydroxyphenylacetic acid
  • homogentisic acid free acid
  • Benzeneacetic acid,2,5-dihydroxy-
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  • 2-(2,5-dihydroxyphenyl)acetic acid
  • HOMOGENTISIC ACID(RG)
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  • 2,5-Dihydroxyphenylacetic acid,99%
  • 1,4-HYDROQUINONEACETIC ACID
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  • 2,5-DIHYDROXYPHENYLACETIC ACID
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  • Melanic acid
  • homogentisicaci
  • 5-dihydroxy-benzeneaceticaci
  • 2,5-Dihydroxyphenylacetic acid, 97%,
  • Homogentisic Acid, ≥ 97.0%
  • 451-13-8
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  • Metabolomics
  • Metabolic Libraries
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  • Amino Acid Library
  • C8
  • Carbonyl Compounds
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