HOMOGENTISIC ACID
- Product Name
- HOMOGENTISIC ACID
- CAS No.
- 451-13-8
- Chemical Name
- HOMOGENTISIC ACID
- Synonyms
- 2-(2,5-dihydroxyphenyl)acetic acid;alcapton;Melanic acid;homogentisicaci;HOMOGENTISIC ACID;Homogentisinic acid;HOMOGENTISIC ACID(RG);Homogentisic Acid >Homogentisic Acid, ≥ 97.0%;homogentisic acid free acid
- CBNumber
- CB5207860
- Molecular Formula
- C8H8O4
- Formula Weight
- 168.15
- MOL File
- 451-13-8.mol
HOMOGENTISIC ACID Property
- Melting point:
- 150-152 °C (lit.)
- Boiling point:
- 257.07°C (rough estimate)
- Density
- 1.3037 (rough estimate)
- refractive index
- 1.5090 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in methanol.
- pka
- 4.4(at 25℃)
- form
- crystalline
- color
- off-white to tan
- Water Solubility
- very faint turbidity
- Merck
- 14,4737
- BRN
- 2692860
- LogP
- 0.860
- CAS DataBase Reference
- 451-13-8(CAS DataBase Reference)
- EPA Substance Registry System
- Benzeneacetic acid, 2,5-dihydroxy- (451-13-8)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H0751
- Product name
- Homogentisic acid
- Purity
- crystalline
- Packaging
- 100mg
- Price
- $140
- Updated
- 2024/03/01
- Product number
- H0751
- Product name
- Homogentisic acid
- Purity
- crystalline
- Packaging
- 500mg
- Price
- $351
- Updated
- 2024/03/01
- Product number
- 92168
- Product name
- Homogentisic acid
- Purity
- analytical standard
- Packaging
- 25MG
- Price
- $126
- Updated
- 2022/05/15
- Product number
- D1050
- Product name
- Homogentisic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $287
- Updated
- 2024/03/01
- Product number
- D1050
- Product name
- Homogentisic Acid
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $923
- Updated
- 2024/03/01
HOMOGENTISIC ACID Chemical Properties,Usage,Production
Chemical Properties
off-white to tan crystals or crystalline powder
Uses
An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.
Uses
Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:
- Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
- Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).
It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).
Definition
ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.
General Description
Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.
Purification Methods
Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]
HOMOGENTISIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from HOMOGENTISIC ACID manufacturers
- Product
- HOMOGENTISIC ACID 451-13-8
- Price
- US $25.00-12.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-05
- Product
- HOMOGENTISIC ACID 451-13-8
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12