HOMOGENTISIC ACID

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HOMOGENTISIC ACID

Product Name: HOMOGENTISIC ACID
CAS No.: 451-13-8
Chemical Name: HOMOGENTISIC ACID
Synonyms: 2-(2,5-dihydroxyphenyl)acetic acid;alcapton;Melanic acid;homogentisicaci;HOMOGENTISIC ACID;Homogentisinic acid;HOMOGENTISIC ACID(RG);Homogentisic Acid >Homogentisic Acid, ≥ 97.0%;homogentisic acid free acid
CBNumber: CB5207860
Molecular Formula: C8H8O4
Formula Weight: 168.15
MOL File: 451-13-8.mol

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HOMOGENTISIC ACID Property

Melting point:: 150-152 °C (lit.)
Boiling point:: 257.07°C (rough estimate)
Density: 1.3037 (rough estimate)
refractive index: 1.5090 (estimate)
storage temp.: 2-8°C
solubility: Soluble in methanol.
pka: 4.4(at 25℃)
form: crystalline
color: off-white to tan
Water Solubility: very faint turbidity
Merck: 14,4737
BRN: 2692860
LogP: 0.860
CAS DataBase Reference: 451-13-8(CAS DataBase Reference)
EPA Substance Registry System: Benzeneacetic acid, 2,5-dihydroxy- (451-13-8)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: AH0589000
TSCA: Yes
HS Code: 29182900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H0751
Product name: Homogentisic acid
Purity: crystalline
Packaging: 100mg
Price: $140
Updated: 2024/03/01

Sigma-Aldrich

Product number: H0751
Product name: Homogentisic acid
Purity: crystalline
Packaging: 500mg
Price: $351
Updated: 2024/03/01

Sigma-Aldrich

Product number: 92168
Product name: Homogentisic acid
Purity: analytical standard
Packaging: 25MG
Price: $126
Updated: 2022/05/15

TCI Chemical

Product number: D1050
Product name: Homogentisic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 1g
Price: $287
Updated: 2024/03/01

TCI Chemical

Product number: D1050
Product name: Homogentisic Acid
Purity: >97.0%(HPLC)(T)
Packaging: 5g
Price: $923
Updated: 2024/03/01

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HOMOGENTISIC ACID Chemical Properties,Usage,Production

Chemical Properties

off-white to tan crystals or crystalline powder

Uses

An intermediate in the metabolism of tyrosine and phenylalanine. Occurs in plants and in the urine of alkaptonurics.

Uses

Homogentisic acid may be used as an analytical reference standard for the quantification of the analyte in the following:

Urine matrices using reversed-phase liquid chromatography tandem mass spectrometry (LC-MS/MS).
Strawberry tree honey samples using reversed phase-high performance liquid chromatography (RP-HPLC) and ion chromatography (IC).

It may also be used as an internal standard for the determination of ascorbic acid (AA) and uric acid (UA) in human plasma samples using high-pressure liquid chromatography–electrochemical detection (HPLC–ECD).

Definition

ChEBI: Homogentisic acid is a dihydroxyphenylacetic acid having the two hydroxy substituents at the 2- and 5-positions. It has a role as a human metabolite and a plant metabolite. It is a dihydroxyphenylacetic acid and a member of hydroquinones. It is functionally related to a phenylacetic acid. It is a conjugate acid of a homogentisate.

General Description

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.

Purification Methods

Crystallise homogentisic acid from EtOH/CHCl3 or H2O (solubility is 85% at 25o). [Beilstein 10 IV 1506.]

HOMOGENTISIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from HOMOGENTISIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: HOMOGENTISIC ACID 451-13-8
Price: US $25.00-12.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-05

Career Henan Chemical Co

Product: HOMOGENTISIC ACID 451-13-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-12

451-13-8, HOMOGENTISIC ACIDRelated Search:

HOMOGENTISIC ACID 2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID (2,5-Dimethoxyphenyl)acetic acid 2-(METHOXY)-5-(TRIFLUOROMETHOXY)PHENYLACETIC ACID HOMOGENTISIC ACID LACTONE,HOMOGENTISIC ACID GAMMA-LACTONE Phenylacetic acid 2,5-DIBENZYLOXYPHENYLACETIC ACID HOMOGENTISIC ACID, [RING-3H] AMINO-(2,4,5-TRIMETHOXY-PHENYL)-ACETIC ACID HOMOGENTISIC ACID ETHYL ESTER GAMMA-METHYL-L-LEUCINE 2-AMINO-2-(2,4,5-TRIMETHOXYPHENYL)ACETIC ACID HYDROCHLORIDE RARECHEM AL BO 1491 (R)-AMINO-(2,5-DIMETHOXY-PHENYL)-ACETIC ACID (R)-AMINO-(2,4,5-TRIMETHOXY-PHENYL)-ACETIC ACID AKOS BBS-00006098 AURORA KA-4815 RARECHEM AL BO 1475

(2,5-dihydroxyphenyl)-aceticaci

2,5-dihydroxy-benzeneaceticaci

2,5-dihydroxybenzeneaceticacid

2-(2,5-dihydroxyphenyl)acetate

alcapton

Homogentisic acid 2,5-Dihydroxyphenylacetic acid

homogentisic acid free acid

Benzeneacetic acid,2,5-dihydroxy-

HoMogentisic acid crystalline

2-(2,5-dihydroxyphenyl)acetic acid

HOMOGENTISIC ACID(RG)

2,5-Dihydroxy-α-toluic acid

Homogentisinic acid

2,5-Dihydroxyphenylacetic acid,95%

2,5-Dihydroxyphenylacetic acid,99%

1,4-HYDROQUINONEACETIC ACID

HOMOGENTISIC ACID

2,5-DIHYDROXYPHENYLACETIC ACID

Homogentisic Acid &gt

Melanic acid

homogentisicaci

5-dihydroxy-benzeneaceticaci

2,5-Dihydroxyphenylacetic acid, 97%,

Homogentisic Acid, ≥ 97.0%

451-13-8

HO2C6H3CH2COOH

Metabolomics

Metabolic Libraries

Organic Building Blocks

Building Blocks

BioChemical

Amino Acid Library

Carbonyl Compounds

Carboxylic Acids

Aromatic Phenylacetic Acids and Derivatives

Aromatics

Intermediates