1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
- Product Name
- 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
- CAS No.
- 144657-66-9
- Chemical Name
- 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
- Synonyms
- 1-Boc-3-formyl-7-azaindole;1-Boc-7-azaindole-3-carboxaldehyde;1-(tert-Butyloxycarbonyl)-3-formyl-7-azaindole;tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate;TERT-BUTYL 3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATEr;1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrro...;1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 3-formyl-, 1,1-dimethylethyl ester;1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester
- CBNumber
- CB52097041
- Molecular Formula
- C13H14N2O3
- Formula Weight
- 246.26
- MOL File
- 144657-66-9.mol
1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Property
- Melting point:
- 124-129 °C
- Boiling point:
- 389.6±45.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C, stored under nitrogen
- pka
- 1.35±0.30(Predicted)
- form
- powder
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 696811
- Product name
- 1-Boc-7-azaindole-3-carboxaldehyde
- Packaging
- 1g
- Price
- $176
- Updated
- 2023/06/20
- Product number
- B695285
- Product name
- tert-Butyl3-Formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Packaging
- 500mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 7135AA
- Product name
- tert-Butyl3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Packaging
- 250mg
- Price
- $103
- Updated
- 2021/12/16
- Product number
- 056455
- Product name
- tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 056455
- Product name
- tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Chemical Properties
Beige powder
Uses
tert-Butyl 3-Formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate is a useful reagent in study of eletrophilic fragment-based design of reversible covalent kinase inhibitors.
Synthesis
4649-09-6
24424-99-5
144657-66-9
To a round bottom flask was added 1H-pyrrolo[2,3-B]pyridine-3-carboxaldehyde (6.6 g, 45 mmol), di-tert-butyl dicarbonate (10.7 g, 50 mmol), 4-dimethylaminopyridine (55 mg, 0.45 mmol), and triethylamine (13 g, 130 mmol), followed by methylene chloride (50 mL). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated to dryness and purified by fast column chromatography to afford the target product 1-Boc-7-azaindole-3-carbaldehyde (9.8 g, 89% yield).
References
[1] Patent: WO2011/23081, 2011, A1. Location in patent: Page/Page column 55
[2] Patent: WO2017/37116, 2017, A1. Location in patent: Page/Page column 143
[3] Canadian Journal of Chemistry, 1992, vol. 70, # 5, p. 1531 - 1536
[4] Patent: WO2011/20193, 2011, A1. Location in patent: Page/Page column 36
[5] Patent: WO2013/45516, 2013, A1. Location in patent: Page/Page column 129; 197
1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester Suppliers
- Tel
- 025-85760892 13376080562
- Fax
- 025-85766769
- sales@habotech.com
- Country
- China
- ProdList
- 884
- Advantage
- 60
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 13598610367 0373-7129549
- Fax
- 0373-8369699
- 2468833170@qq.com
- Country
- China
- ProdList
- 932
- Advantage
- 58
- Tel
- 15026594951
- Fax
- 0556-5030632
- rs@raise-chem.com
- Country
- China
- ProdList
- 4454
- Advantage
- 55
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- 010-1234567 18521000990
- Fax
- 86-021-33275113
- sonyuanchemical@163.com
- Country
- China
- ProdList
- 6479
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51395
- Advantage
- 80
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
View Lastest Price from 1-(tert-Butoxycarbonyl)-3-formyl-7-azaindole, 3-Formyl-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester manufacturers
- Product
- TERT-BUTYL 3-FORMYL-1H-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLATE 144657-66-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-21