Synthesis
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METHYL 3-HYDROXY-4-METHYLBENZOATE

Synthesis
Product Name
METHYL 3-HYDROXY-4-METHYLBENZOATE
CAS No.
3556-86-3
Chemical Name
METHYL 3-HYDROXY-4-METHYLBENZOATE
Synonyms
3,4-Cresotic acid methyl ester;METHYL 3-HYDROXY-4-METHYLBENZOATE;Methyl 4-Methyl-3-hydroxybenzoate;3-HYDROXY-P-TOLUIC ACID METHYL ESTER;Methyl 3-hydroxy-4-methylbenzoate 98%;3-HYDROXY-4-METHYLBENZOIC ACID METHYL ESTER;benzoic acid, 3-hydroxy-4-methyl-, methyl ester
CBNumber
CB5209910
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
3556-86-3.mol
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METHYL 3-HYDROXY-4-METHYLBENZOATE Property

Melting point:
119.0-120.5 °C
Boiling point:
294.6±20.0 °C(Predicted)
Density 
1.169±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
Acetone (Slightly), Chloroform (Slightly)
pka
9.50±0.10(Predicted)
form 
Solid
color 
Tan
Stability:
Hygroscopic
CAS DataBase Reference
3556-86-3(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M322970
Product name
Methyl4-Methyl-3-hydroxybenzoate
Packaging
2.5g
Price
$45
Updated
2021/12/16
Usbiological
Product number
283450
Product name
Methyl 3-hydroxy-4-methylbenzoate
Packaging
2g
Price
$399
Updated
2021/12/16
Usbiological
Product number
164917
Product name
Methyl 4-Methyl-3-hydroxybenzoate
Packaging
1g
Price
$403
Updated
2021/12/16
Apolloscientific
Product number
OR311176
Product name
Methyl3-hydroxy-4-methylbenzoate
Purity
98%
Packaging
25g
Price
$435
Updated
2021/12/16
SynQuest Laboratories
Product number
2729-1-71
Product name
Methyl 3-hydroxy-4-methylbenzoate
Purity
98%
Packaging
25g
Price
$480
Updated
2021/12/16
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METHYL 3-HYDROXY-4-METHYLBENZOATE Chemical Properties,Usage,Production

Synthesis

Methyl 3-hydroxy-4-methylbenzoate is synthesized by the following steps:The amino ester 35 (60 g, 0.364 mol) was added to dil. H2SO4 (125 ml  conc. H2SO4 diluted with 1 L water) and warmed on a water bath until all  the compound was dissolved. Cold water (800 ml) was added and the  mixture was cooled to 0 °C. NaNO2 (62.6 g, 0.907 mol) was added to this  mixture with constant stirring. It was then stirred at room temperature for 15 minutes.  Then, urea (65.4 g, 1.09 mol) was added in portions. The mixture was warmed at 50 ºC for  15 minutes (temperature was not allowed to rise above 55 ºC). EtOAc was added to the reaction mixture and washed with brine, dried (anhydrous Na2SO4), filtered and  concentrated under reduced pressure to afford a colourless solid (26.56 g).

Uses

Methyl 4-Methyl-3-hydroxybenzoate is used in the preparation of potent antimalarial agents. Also used in the preparation of aromatic inhibtors of anthranilate synthase.

METHYL 3-HYDROXY-4-METHYLBENZOATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 3-HYDROXY-4-METHYLBENZOATE Suppliers

China 79 Europe 2 Germany 2 India 2 Switzerland 1 United Kingdom 5 United States 12 Global 103
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from METHYL 3-HYDROXY-4-METHYLBENZOATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Methyl 3-Hydroxy-4-methylbenzoate 3556-86-3
Price
US $1.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
20T
Release date
2024-07-19
Career Henan Chemical Co
Product
METHYL 3-HYDROXY-4-METHYLBENZOATE 3556-86-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kgs
Release date
2020-01-09

3556-86-3, METHYL 3-HYDROXY-4-METHYLBENZOATERelated Search:

METHYL 3-HYDROXY-4-METHYLBENZOATE AMAROGENTIN METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE METHYL 3-METHOXY-4-METHYLBENZOATE DIETHYL 2,5-DIHYDROXYTEREPHTHALATE METHYL 2,4-DIHYDROXY-3-METHYLBENZOATE METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE METHYL 2-HYDROXY-3-METHYLBENZOATE METHYL 2-HYDROXY-4-METHYLBENZOATE METHYL 2-HYDROXY-5-METHYLBENZOATE METHYL 2,4-DIMETHOXY-6-METHYLBENZOATE METHYL 3-HYDROXY-2-METHYLBENZOATE 3-Hydroxy-4-methylbenzoic acid RARECHEM AL BF 1403 4-METHYL-3-BENZYLOXYBENZOIC ACID METHYL ESTER Purpuromycin METHYL 3,5-DIMETHOXY-4-METHYLBENZOATE METHYL 3,5-DIHYDROXY-4-METHYLBENZOATE

  • benzoic acid, 3-hydroxy-4-methyl-, methyl ester
  • Methyl 4-Methyl-3-hydroxybenzoate
  • METHYL 3-HYDROXY-4-METHYLBENZOATE
  • 3-HYDROXY-4-METHYLBENZOIC ACID METHYL ESTER
  • 3-HYDROXY-P-TOLUIC ACID METHYL ESTER
  • 3,4-Cresotic acid methyl ester
  • Methyl 3-hydroxy-4-methylbenzoate 98%
  • 3556-86-3
  • Esters
  • Phenyls & Phenyl-Het