Cyclofenil
- Product Name
- Cyclofenil
- CAS No.
- 2624-43-3
- Chemical Name
- Cyclofenil
- Synonyms
- f6066;h3452;oginex;ondonid;sexovar;ici48213;fertodur;ondogyne;sexadieno;cyclofenyl
- CBNumber
- CB5212631
- Molecular Formula
- C23H24O4
- Formula Weight
- 364.44
- MOL File
- 2624-43-3.mol
Cyclofenil Property
- Melting point:
- 135-136°
- Boiling point:
- 415.62°C (rough estimate)
- Density
- 1.0986 (rough estimate)
- refractive index
- 1.4433 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: 10 mg/mL at 60 °C, soluble
- form
- solid
- color
- White to Off-White
- CAS DataBase Reference
- 2624-43-3(CAS DataBase Reference)
Safety
- WGK Germany
- 2
- RTECS
- GO7550000
- Toxicity
- LD50 oral in rat: > 12gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 18676
- Product name
- Cyclofenil
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18676
- Product name
- Cyclofenil
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 18676
- Product name
- Cyclofenil
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- C987835
- Product name
- Cyclofenil
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- C987835
- Product name
- Cyclofenil
- Packaging
- 10g
- Price
- $575
- Updated
- 2021/12/16
Cyclofenil Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
Ondogyne,Roussel,France,1970
Uses
Cyclofenil is a weak nonsteroidal estrogen with ovulation induction properties. Mammalian hormone.
Definition
ChEBI: Cyclofenil is an organic molecular entity.
Manufacturing Process
(A) Preparation of p-Hydroxy-p'-Methoxybenzhydrylidenecyclohexane: To a
Grignard solution prepared from 110 g of magnesium (4.5 mols) and 840 g of
p-bromoanisole (4.5 mols) in one liter of anhydrous ether, there was added
dropwise with vigorous agitation 307 g of p-hydroxyphenyl cyclohexyl ketone
(1.5 mols) dissolved in one liter of anhydrous ether. Upon completion of the
addition the reaction mixture was refluxed for 2.5 hours with agitation, and
was then cooled. Thereupon 15 mols of ammonium chloride dissolved in 3
liters of water were added. The ethereal layer was separated, washed with
water, dried over anhydrous sodium sulfate and distilled. Yield: 370 g. BP
180° to 190°C at 0.1 mm. The substance was recrystallized from a mixture of
carbon tetrachloride and petroleum ether. MP 145° to 146°C.
(B)Preparation of p,p'-Dihydroxybenzhydrylidenecyclohexane: A mixture of
118 g of p-hydroxy-p'-methoxybenzhydrylidenecyclohexane (0.4 mol), 120 g
of potassium hydroxide pellets and 500 ml of triethylene glycol was stirred 4
hours at 220°C. When the reaction mixture was poured into water the
substance crystallized, and the crystals were filtered off and washed with water. The substance was then recrystallized from a mixture of ethanol and
petroleum ether. Yield: 104 g. MP 235° to 236°C.
(C) Preparation of p,p'-Diacetoxybenzhydrylidenecyclohexane: 56 g of p,p'-
dihydroxybenzhydrylidenecyclohexane (0.2 mol) was mixed with 250 ml of
acetic anhydride and 500 ml of pyridine. The mixture was refluxed for 2 hours
and was then poured into water, the substance crystallizing out. The crystals
were filtered off and washed with water. Finally the substance was
recrystallized from ethanol. Yield: 62 g. MP 135° to 136°C.
Therapeutic Function
Ovulation stimulant
Cyclofenil Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cyclofenil manufacturers
- Product
- Cyclofenil 2624-43-3
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-15