Aselizumab

Product Name: Aselizumab
CAS No.: 395639-53-9
Chemical Name: Aselizumab
Synonyms: Bnp 001;Hudreg-55;Aselizumab;Aselizumab [inn];Research Grade Aselizumab;Research Grade Teneliximab;Research Grade Aselizumab (DHD03301);Immunoglobulin G4, anti-(L-selectin) (human-mouse monoclonal hudreg-55 heavy chain), disulfide with human-mouse monoclonal hudreg-55 light chain, dimer
CBNumber: CB52128703
Formula Weight: 0
MOL File: Mol file

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Aselizumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Aselizumab Chemical Properties,Usage,Production

Uses

Aselizumab (HuDreg-55) is an humanized IgG4 mAb against L-selectin. However, L-selectin (CD62L) is a cell adhesion molecule expressed on circulating neutrophils. It regulates migrating cells to chemotaxis towards the site of injury. Aselizumab may be account for a high rate of infections and leucopenia after truma[1][2].

in vivo

Aselizumab (10 mg/kg; i.v.; single dose) shows terminal elimination half-lives at 12.0 days in rhesus monkeys^[3].

References

[1] Seekamp A, et al. The effect of anti-L-selectin (aselizumab) in multiple traumatized patients--results of a phase II clinical trial. Crit Care Med. 2004 Oct;32(10):2021-8. DOI:10.1097/01.ccm.0000142396.59236.f3
[2] Rahman I, et al. L-selectin regulates human neutrophil transendothelial migration. J Cell Sci. 2021 Feb 8;134(3):jcs250340. DOI:10.1242/jcs.250340
[3] Co MS, et al. Properties and pharmacokinetics of two humanized antibodies specific for L-selectin. Immunotechnology. 1999 Mar;4(3-4):253-66. DOI:10.1016/s1380-2933(98)00024-4

Aselizumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Aselizumab Suppliers

China 17 United States 2 Global 19

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395639-53-9, AselizumabRelated Search:

Bevacizumab Aselizumab Rituximab Avelumab Eculizumab Efungumab TocilizuMab Necitumumab Opicinumab Cotara (9CI)

Aselizumab

Aselizumab [inn]

Bnp 001

Hudreg-55

Immunoglobulin G4, anti-(L-selectin) (human-mouse monoclonal hudreg-55 heavy chain), disulfide with human-mouse monoclonal hudreg-55 light chain, dimer

Research Grade Aselizumab (DHD03301)

Research Grade Teneliximab

Research Grade Aselizumab

395639-53-9