ChemicalBook > CAS DataBase List > Nelfinavir mesylate

Nelfinavir mesylate

Product Name
Nelfinavir mesylate
CAS No.
159989-65-8
Chemical Name
Nelfinavir mesylate
Synonyms
Nelfin;AG-1343;viracept;Nelfinavir1;Nelfinavir-d9;AG1343 Mesylate;AG 1343 Mesylate;AG-1343 Mesylate;NELFINAVIR MESYLATE;Nelfinavir nesylate
CBNumber
CB5213805
Molecular Formula
C33H49N3O7S2
Formula Weight
663.89
MOL File
159989-65-8.mol
More
Less

Nelfinavir mesylate Property

Melting point:
131-135°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: ≥2mg/mL
pka
pKa -1.20(at 25℃)
form 
powder
color 
white to off-white
Water Solubility 
4.5g/L(temperature not stated)
Merck 
14,6443
InChIKey
NQHXCOAXSHGTIA-SKXNDZRYSA-N
CAS DataBase Reference
159989-65-8(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
RTECS 
NW6995333
HS Code 
29334900
Hazardous Substances Data
159989-65-8(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0013
Product name
Nelfinavir mesylate hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$98.6
Updated
2021/12/16
Sigma-Aldrich
Product number
PZ0013
Product name
Nelfinavir mesylate hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$393
Updated
2021/12/16
TCI Chemical
Product number
N0986
Product name
Nelfinavir Mesylate Hydrate
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$187
Updated
2021/12/16
TCI Chemical
Product number
N0986
Product name
Nelfinavir Mesylate Hydrate
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$374
Updated
2021/12/16
Cayman Chemical
Product number
15144
Product name
Nelfinavir (mesylate)
Purity
≥98%
Packaging
5mg
Price
$45
Updated
2021/12/16
More
Less

Nelfinavir mesylate Chemical Properties,Usage,Production

Description

Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.

Chemical Properties

White Powder

Originator

Agouron (US)

Uses

Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.

Uses

An antiviral. HIV protease inhibitor.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.

brand name

Viracept (Agouron).

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .

Biochem/physiol Actions

Nelfinavir mesylate hydrate, also known as AG1343, is used as a therapeutic agent for acquired immunodeficiency syndrome (AIDS). It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc). In addition, nelfinavir mesylate hydrate reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It also stimulate autophagy and exhibit anti-cancer property.

Nelfinavir mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Nelfinavir mesylate Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999- ;0411-62910999-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3752
Advantage
58
T&W GROUP
Tel
021-61551611-
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9758
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9914
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
86-21-58998985
Fax
(86) 21-58955996
Email
apisales@chemexpress.com.cn
Country
China
ProdList
7557
Advantage
61
More
Less

View Lastest Price from Nelfinavir mesylate manufacturers

Career Henan Chemical Co
Product
Nelfinavir mesylate 159989-65-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

159989-65-8, Nelfinavir mesylateRelated Search:


  • 8a-beta))-a-betmonomethanesulfonate(salt)
  • droxy-2-methylbenzoyl)amino)-4-(phenylthio)butyl)-,(3s-(2(2,s*,3s*),3-alpha,4
  • viracept
  • 3-Isoquinolinecarboxamide, N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-, (3S,4aS,8aS)-, methanesulfonate (1:1)
  • (3S,4AS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl
  • NELFINAVIR MESYLATE
  • AG-1343
  • (3s,4as,8as)-n-(1,1-dimethylethyl)decahydro-2-[(2r,3r)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide mesylate
  • NELFINAVIRMESYLATE(SUBJECTTOPATENTFREE)
  • Nelfinavir nesylate
  • (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamidemethanesulfonate
  • Nelfinavir Mesylate (200 mg)
  • Nelfin
  • Nelfinavir (Methanesulfonate)
  • AG 1343 Mesylate
  • AG1343 Mesylate
  • AG-1343 Mesylate
  • Nelfinavir1
  • (3S,4aS,8aS)-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methyl-benzoyl)amino]-4-phenylsulfanyl-butyl]-N-tert-butyl-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
  • N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-(3S,4aS,8aS)-3-isoquinolinecarboxamide, methanesulfonate (1:1)
  • Nelfinavir mesylate hydrate
  • Nelfinavir methanesulfonate hydrate
  • Nelfinavir mesylate, >=98%
  • Nelfinavir-d9
  • (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
  • Nelfinavir Mesylate (AG 1343 Mesylate)
  • Nelfinavir mesylate - AG 1343
  • AG 1343 MESYLATE;AG1343 MESYLATE;AG-1343 MESYLATE
  • (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide methanesulfonate
  • 159989-65-8
  • C32H45N3O4SCH4O3SxH2O
  • C32H45N3O4S
  • C33H49N3O7S2
  • C32H45N3O4SCH4O2S2
  • Pfizer compounds
  • peptides
  • Anti-virals
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Non-nucleoside Reverse Transcriptase
  • Pharmaceuticals
  • Nelfinavir
  • Active Pharmaceutical Ingredients
  • Anti-viral Compounds