ChemicalBook > CAS DataBase List > Nelfinavir mesylate

Nelfinavir mesylate

Product Name
Nelfinavir mesylate
CAS No.
159989-65-8
Chemical Name
Nelfinavir mesylate
Synonyms
viracept;Nelfin;AG-1343;Nelfinavir1;Nelfinavir-d9;AG1343 Mesylate;AG 1343 Mesylate;AG-1343 Mesylate;NELFINAVIR MESYLATE;Nelfinavir nesylate
CBNumber
CB5213805
Molecular Formula
C33H49N3O7S2
Formula Weight
663.89
MOL File
159989-65-8.mol
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Nelfinavir mesylate Property

Melting point:
131-135°C
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: ≥2mg/mL
pka
pKa -1.20(at 25℃)
form 
powder
color 
white to off-white
Water Solubility 
4.5g/L(temperature not stated)
Merck 
14,6443
BCS Class
2,4
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey
NQHXCOAXSHGTIA-SKXNDZRYSA-N
CAS DataBase Reference
159989-65-8(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
NW6995333
HS Code 
29334900
Hazardous Substances Data
159989-65-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0013
Product name
Nelfinavir mesylate hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0013
Product name
Nelfinavir mesylate hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$470
Updated
2024/03/01
TCI Chemical
Product number
N0986
Product name
Nelfinavir Mesylate Hydrate
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$233
Updated
2024/03/01
TCI Chemical
Product number
N0986
Product name
Nelfinavir Mesylate Hydrate
Purity
>97.0%(HPLC)
Packaging
100mg
Price
$415
Updated
2024/03/01
Cayman Chemical
Product number
15144
Product name
Nelfinavir (mesylate)
Purity
≥98%
Packaging
5mg
Price
$57
Updated
2024/03/01
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Nelfinavir mesylate Chemical Properties,Usage,Production

Description

Viracept was launched in the US as an orally-available, non-peptidic HIV protease inhibitor. It is prepared in an eight step synthesis beginning with N- (benzyloxycarbonyl)-L-serine β-lactone. The HIV protease inhibitory activity blocks the processing of gag and gagpol polyproteins that are required for viral maturation. It was discovered based on an experimentally derived 3D-structure of HIV-1 protease. Viracept has a high oral bioavailability, lacks toxicity, and has a resistance profile different from other protease inhibitors. Viracept with ziduvudine and larnivudine generated a 98% mean reduction from baseline in viral load after 24 weeks compared to ziduvudine and larnivudine alone. Viracept also had better CD4 counts and is available in adult and pediatric formulations.

Chemical Properties

White Powder

Originator

Agouron (US)

Uses

Nelfinavir Mesylate is an antiviral. HIV protease inhibitor. It is a COVID19-related research product.

Definition

ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of nelfinavir and methanesulfonic acid. It is used for treatment of HIV and also exhibits some anticancer properties.

brand name

Viracept (Agouron).

Biological Activity

Orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (K i = 2 nM) in vitro .

Biochem/physiol Actions

Nelfinavir mesylate hydrate, also known as AG1343, is used as a therapeutic agent for acquired immunodeficiency syndrome (AIDS). It acts as an antifibrotic agent and is used to treat pulmonary fibrosis in patients with systemic sclerosis (SSc). In addition, nelfinavir mesylate hydrate reduces inflammation by activating protein phosphatase 2 (PP-2) and blocking mitogen-activated protein kinases (MAPK) signaling in macrophages. It also stimulate autophagy and exhibit anti-cancer property.

storage

Store at +4°C

References

1) Olmo?et al.?(2006),?A review of nelfinavir for the treatment of HIV infection; Expert Opin. Drug Metab. Toxicol.,?2?285 2) Bruning?et al.?(2010),?New prospects for nelfinavir in non-HIV-related diseases; Curr. Mol. Pharmacol.,?3?91 3) Gills?et al.?(2007),?Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo; Clin. Cancer Res,?13?5183 4) Shim?et al. (2012),?Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir; J. Natl. Cancer Inst,,?104?1576

Nelfinavir mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Nelfinavir mesylate Suppliers

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View Lastest Price from Nelfinavir mesylate manufacturers

Career Henan Chemical Co
Product
Nelfinavir mesylate 159989-65-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

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  • N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-(3S,4aS,8aS)-3-isoquinolinecarboxamide, methanesulfonate (1:1)
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  • Nelfinavir methanesulfonate hydrate
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  • Nelfinavir-d9
  • (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[[(3-hydroxy-2-methylphenyl)-oxomethyl]amino]-4-(phenylthio)butyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
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  • Nelfinavir mesylate - AG 1343
  • AG 1343 MESYLATE;AG1343 MESYLATE;AG-1343 MESYLATE
  • (3S,4aS,8aS)-N-(tert-Butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-methylbenzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide methanesulfonate
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  • Glumetinib Impurity 2
  • 159989-65-8
  • C32H45N3O4SCH4O3SxH2O
  • C32H45N3O4S
  • C33H49N3O7S2
  • C32H45N3O4SCH4O2S2
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