ChemicalBook > CAS DataBase List > 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE

Product Name: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE
CAS No.: 5034-74-2
Chemical Name: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE
Synonyms: 5-BROMO-2-VANILLIN;BUTTPARK 153\33-74;5-BROMO-O-VANILLIN;Vanillin Impurity 17;OTAVA-BB BB7018802005;5-BROMO-3-METHOXYSALICYLALDEHYDE;3-Methoxy-5-bromosalicylaldehyde;5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE;Benzaldehyde, 5-bromo-2-hydroxy-3-methoxy-;5-Bromo-2-hydroxy-3-methoxybenzaldehyde,98%
CBNumber: CB5221945
Molecular Formula: C8H7BrO3
Formula Weight: 231.04
MOL File: 5034-74-2.mol

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5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE Property

Melting point:: 125-127 °C (lit.)
Boiling point:: 277.2±35.0 °C(Predicted)
Density: 1.6494 (rough estimate)
refractive index: 1.4730 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 7.62±0.23(Predicted)
Appearance: White to off-white Solid
Sensitive: Air Sensitive
BRN: 2328601
CAS DataBase Reference: 5034-74-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 410470
Product name: 5-Bromo-2-hydroxy-3-methoxybenzaldehyde
Purity: 97%
Packaging: 25g
Price: $289
Updated: 2025/07/31

TRC

Product number: B678855
Product name: 5-Bromo-2-hydroxy-3-methoxybenzaldehyde
Packaging: 1g
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 169684
Product name: 5-Bromo-2-hydroxy-3-methoxybenzenecarbaldehyde
Packaging: 1g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB63398
Product name: 5-Bromo-2-hydroxy-3-methoxybenzaldehyde
Packaging: 25g
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: J96019
Product name: 5-Bromo-2-hydroxy-3-methoxybenzaldehyde
Packaging: 1g
Price: $10
Updated: 2021/12/16

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5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

brown powder

Uses

5-Bromo-2-hydroxy-3-methoxybenzaldehyde may be employed for the following syntheses:

ailanthoidol, via Stille coupling
6-bromo-8-methoxy-3-(methoxycarbonyl)-2H-chromen-2-one
benzimidazole-based ligand, 2-(1H-benzoimidazol-2-yl)-4-bromo-6-methoxy-phenol (HL)
chromogenic reagent, 5-bromo-2-hydroxy-3-methoxybenzaldehyde-p-hydroxy benzoic hydrazone
(E)-N′-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-hydroxybenzohydrazide monohydrate

Synthesis

148-53-8

5034-74-2

To a solution of o-vanillin (11; 4.0 g, 0.026 mol) in acetic acid (80 mL) was added sodium acetate (2.37 g, 0.029 mol) at 0 °C, followed by slow dropwise addition of bromine (1.49 mL, 0.029 mol). The reaction mixture was stirred at room temperature for 30 min. After completion of the reaction, water (100 mL) was added and the aqueous phase was extracted with dichloromethane (3 x 80 mL). The organic phases were combined, washed sequentially with water (100 mL) and brine (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (petroleum ether:ethyl acetate = 19:1) to afford 5-bromo-2-hydroxy-3-methoxybenzaldehyde (26; 6.0 g, 98%) as a yellow solid with a melting point of 119-123 °C (literature value 19: 122-124 °C).1H NMR (400 MHz, CDCl3/TMS): δ = 3.92 (3H, s, OCH3), 7.18 (1H, d, J = 2.4 Hz, 4-H), 7.31 (1H, d, J = 2.4 Hz, 6-H), 9.86 (1H, s, CHO), 11.00 (1H, s, OH).13C NMR (100 MHz, CDCl3): δ = 56.3 (OCH3), 111.1 (C-5), 120.8 (C-6), 121.3 (C-1), 126.1 (C-4), 149.3 (C-2), 150.9 (C-3), 195.4 (CHO).The 1H NMR and 13C NMR data are in agreement with the literature values19.

References

[1] Synthesis (Germany), 2017, vol. 49, # 6, p. 1190 - 1205
[2] Journal of the Iranian Chemical Society, 2011, vol. 8, # 2, p. 531 - 536
[3] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, p. 503 - 508
[4] Chemische Berichte, 1986, vol. 119, # 4, p. 1374 - 1399
[5] Journal of the Chemical Society. Perkin Transactions 2, 2000, # 6, p. 1119 - 1123

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

3-Methoxysalicylaldehyde Bromine Acetic acid

Preparation Products

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5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE manufacturers

Career Henan Chemical Co

Product: 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE 5034-74-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg;10kg;100kg
Release date: 2019-08-29

5034-74-2, 5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDERelated Search:

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE 2-BROMO-5-HYDROXY-4-METHOXYBENZALDEHYDE,2-Bromo-5-hydroxy-4-methoxybenzaldehyde 95%,2-Bromo-5-hydroxy-4-methoxybenzaldehyde95% 5-Bromovanillin 6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE 99+%,6-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE,6-Bromo-2-hydroxy-2-methoxybenzaldehyde 2-BROMO-3-HYDROXY-4-METHOXYBENZALDEHYDE 6-BROMOVANILLIN/2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE,2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE 2,3-DIBROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE 5-Bromosalicylaldehyde Vanillin 3-Methoxysalicylaldehyde 3-BROMO-2,5,6-TRIMETHOXYBENZOIC ACID 2,3-DIBROMO-5-ETHOXY-6-HYDROXYBENZALDEHYDE 6-Bromo-1,3-benzodioxole-4-carbaldehyde RARECHEM AL BF 0905 (4-BROMO-2-FORMYL-6-METHOXY-PHENOXY)-ACETIC ACID ETHYL ESTER 5-BROMO-2-HYDROXY-3-METHOXYBENZOIC ACID 2,3-DIBROMO-6-HYDROXY-5-METHOXY-BENZALDEHYDE CHEMBRDG-BB 6763869

OTAVA-BB BB7018802005

5-BROMO-O-VANILLIN

BUTTPARK 153\33-74

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE

5-BROMO-2-HYDROXY-3-METHOXYBENZENECARBALDEHYDE

5-BROMO-3-METHOXYSALICYLALDEHYDE

5-BROMO-2-VANILLIN

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE 98%

3-Methoxy-5-bromosalicylaldehyde

5-Bromo-2-hydroxy-3-methoxybenzaldehyde,98%

Benzaldehyde, 5-bromo-2-hydroxy-3-methoxy-

N-cyclohexyl-N-[(cyclohexylamino)-oxomethyl]-4-[formyl(methyl)amino]benzamide

5-Bromo-2-hydroxy-3-methoxybenzaldehyde,5-Bromo-3-methoxysalicylaldehyde

5-BROMO-2-HYDROXY-3-METHOXYBENZALDEHYDE ISO 9001：2015 REACH

Vanillin Impurity 17

5034-74-2

ARYL HALIDE

Aldehydes

Building Blocks

Carbonyl Compounds

Organic Building Blocks

Aromatic Aldehydes & Derivatives (substituted)