ChemicalBook > CAS DataBase List > 3-Chloro-5-fluorobenzonitrile

3-Chloro-5-fluorobenzonitrile

Product Name
3-Chloro-5-fluorobenzonitrile
CAS No.
327056-73-5
Chemical Name
3-Chloro-5-fluorobenzonitrile
Synonyms
CAS:327056-73-5;BUTTPARK 45\01-07;SALOR-INT L301019-1EA;3-CHLORO-5-FLUOROBENZONITRILE;3-chloro-5-fluorobenzenenitrile;3-chloro-5-fluorophenyl nitrile;Benzonitrile, 3-chloro-5-fluoro-;3-Chloro-5-fluorobenzonitrile 97%;3-Chloro-5-fluorobenzonitrile,98%
CBNumber
CB5228959
Molecular Formula
C7H3ClFN
Formula Weight
155.56
MOL File
327056-73-5.mol
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3-Chloro-5-fluorobenzonitrile Property

Melting point:
54-59 °C(lit.)
Boiling point:
195.0±20.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
Flash point:
192 °F
storage temp. 
Sealed in dry,Room Temperature
form 
Crystalline Powder
color 
Slightly yellow
CAS DataBase Reference
327056-73-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
36/37/38-20/21/22
Safety Statements 
22-24/25-36/37/39-26
WGK Germany 
3
Hazard Note 
Toxic
HazardClass 
6.1
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
655171
Product name
3-Chloro-5-fluorobenzonitrile
Purity
97%
Packaging
25g
Price
$116.2
Updated
2025/07/31
Sigma-Aldrich
Product number
655171
Product name
3-Chloro-5-fluorobenzonitrile
Purity
97%
Packaging
5g
Price
$43
Updated
2023/06/20
TRC
Product number
C584775
Product name
3-Chloro-5-fluorobenzonitrile
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
C584775
Product name
3-Chloro-5-fluorobenzonitrile
Packaging
500mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
3637-7-35
Product name
3-Chloro-5-fluorobenzonitrile
Purity
98%
Packaging
5G
Price
$25
Updated
2021/12/16
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3-Chloro-5-fluorobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis

33863-76-2

557-21-1

327056-73-5

The general procedure for the synthesis of 3-chloro-5-fluorobenzonitrile from 1-bromo-3-chloro-5-fluorobenzene and zinc cyanide was as follows: 1-bromo-3-chloro-5-fluorobenzene (80 g, 480 mmol), zinc cyanide (33.65 g, 290 mmol), and zinc powder (0.94 g, 14.46 mmol) in a N,N-dimethylformamide (DMF, 340 mL) The mixture was stirred at room temperature for 5 min. Subsequently, dichloro[1,1 '-bis(diphenylphosphino)ferrocene]palladium(II) (4.99 g, 16 mmol) was added and the mixture was heated to reflux for 50 minutes. After completion of the reaction, the mixture was cooled to room temperature, filtered through Arbocel? and washed with ether/pentane (50:50, 7 x 100 mL). After separation of the phases, the organic phase was diluted with water (100 mL) and extracted with additional ether/pentane (50:50, 3 x 100 mL). The organic solutions were combined, washed with water, dried over magnesium sulfate and subsequently concentrated under vacuum. The residue was purified by distillation under reduced pressure to afford 3-chloro-5-fluorobenzonitrile as a colorless solid in 66% yield (48.5 g). Mass spectrometry (LRMS) analysis showed: m/z APCI 155 [MH+].

References

[1] Patent: WO2006/67587, 2006, A2. Location in patent: Page/Page column 32; 33

3-Chloro-5-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-5-fluorobenzonitrile Suppliers

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View Lastest Price from 3-Chloro-5-fluorobenzonitrile manufacturers

Career Henan Chemical Co
Product
3-Chloro-5-fluorobenzonitrile 327056-73-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-27

327056-73-5, 3-Chloro-5-fluorobenzonitrileRelated Search:

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  • SALOR-INT L301019-1EA
  • 3-CHLORO-5-FLUOROBENZONITRILE
  • BUTTPARK 45\01-07
  • 3-Chloro-5-fluorobenzonitrile,98%
  • 3-chloro-5-fluorobenzenenitrile
  • 3-Chloro-5-fluorobenzonitrile 97%
  • 3-chloro-5-fluorophenyl nitrile
  • Benzonitrile, 3-chloro-5-fluoro-
  • CAS:327056-73-5
  • 327056-73-5
  • C7H3CIFN
  • Building Blocks
  • C6 to C7
  • Organic Building Blocks
  • Nitrogen Compounds
  • Cyanides/Nitriles
  • C6 to C7
  • Cyanides/Nitriles
  • Nitrogen Compounds