3-Chloro-5-fluorobenzonitrile
- Product Name
- 3-Chloro-5-fluorobenzonitrile
- CAS No.
- 327056-73-5
- Chemical Name
- 3-Chloro-5-fluorobenzonitrile
- Synonyms
- CAS:327056-73-5;BUTTPARK 45\01-07;SALOR-INT L301019-1EA;3-CHLORO-5-FLUOROBENZONITRILE;3-chloro-5-fluorobenzenenitrile;3-chloro-5-fluorophenyl nitrile;Benzonitrile, 3-chloro-5-fluoro-;3-Chloro-5-fluorobenzonitrile 97%;3-Chloro-5-fluorobenzonitrile,98%
- CBNumber
- CB5228959
- Molecular Formula
- C7H3ClFN
- Formula Weight
- 155.56
- MOL File
- 327056-73-5.mol
3-Chloro-5-fluorobenzonitrile Property
- Melting point:
- 54-59 °C(lit.)
- Boiling point:
- 195.0±20.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- Flash point:
- 192 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Crystalline Powder
- color
- Slightly yellow
- CAS DataBase Reference
- 327056-73-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 22-24/25-36/37/39-26
- WGK Germany
- 3
- Hazard Note
- Toxic
- HazardClass
- 6.1
- HS Code
- 29269090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 655171
- Product name
- 3-Chloro-5-fluorobenzonitrile
- Purity
- 97%
- Packaging
- 25g
- Price
- $116.2
- Updated
- 2025/07/31
- Product number
- 655171
- Product name
- 3-Chloro-5-fluorobenzonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $43
- Updated
- 2023/06/20
- Product number
- C584775
- Product name
- 3-Chloro-5-fluorobenzonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C584775
- Product name
- 3-Chloro-5-fluorobenzonitrile
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 3637-7-35
- Product name
- 3-Chloro-5-fluorobenzonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $95
- Updated
- 2021/12/16
3-Chloro-5-fluorobenzonitrile Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
33863-76-2
557-21-1
327056-73-5
The general procedure for the synthesis of 3-chloro-5-fluorobenzonitrile from 1-bromo-3-chloro-5-fluorobenzene and zinc cyanide was as follows: 1-bromo-3-chloro-5-fluorobenzene (80 g, 480 mmol), zinc cyanide (33.65 g, 290 mmol), and zinc powder (0.94 g, 14.46 mmol) in a N,N-dimethylformamide (DMF, 340 mL) The mixture was stirred at room temperature for 5 min. Subsequently, dichloro[1,1 '-bis(diphenylphosphino)ferrocene]palladium(II) (4.99 g, 16 mmol) was added and the mixture was heated to reflux for 50 minutes. After completion of the reaction, the mixture was cooled to room temperature, filtered through Arbocel? and washed with ether/pentane (50:50, 7 x 100 mL). After separation of the phases, the organic phase was diluted with water (100 mL) and extracted with additional ether/pentane (50:50, 3 x 100 mL). The organic solutions were combined, washed with water, dried over magnesium sulfate and subsequently concentrated under vacuum. The residue was purified by distillation under reduced pressure to afford 3-chloro-5-fluorobenzonitrile as a colorless solid in 66% yield (48.5 g). Mass spectrometry (LRMS) analysis showed: m/z APCI 155 [MH+].
References
[1] Patent: WO2006/67587, 2006, A2. Location in patent: Page/Page column 32; 33
3-Chloro-5-fluorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5-fluorobenzonitrile Suppliers
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- Country
- Germany
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View Lastest Price from 3-Chloro-5-fluorobenzonitrile manufacturers
- Product
- 3-Chloro-5-fluorobenzonitrile 327056-73-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-27