2-HYDROXY-5-NITROBENZYL BROMIDE

Product Name: 2-HYDROXY-5-NITROBENZYL BROMIDE
CAS No.: 772-33-8
Chemical Name: 2-HYDROXY-5-NITROBENZYL BROMIDE
Synonyms: KOSHLAND I;KOSHLAND REAGENT;KOSHLAND'S REAGENT;KOSHLAND'S REAGENT I;Koshland's reagent 1;Koshland's Reagent 1;α-bromo-4-nitro-o-creso;α-bromo-4-nitro-o-cresol;a-Bromo-4-nitro-o-cresol;α-bromo-4-nitro-o-cresol
CBNumber: CB5229370
Molecular Formula: C7H6BrNO3
Formula Weight: 232.03
MOL File: 772-33-8.mol

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2-HYDROXY-5-NITROBENZYL BROMIDE Property

Melting point:: 144-149 °C(lit.)
Boiling point:: 383.0±32.0 °C(Predicted)
Density: 1.795
refractive index: 1.6090 (estimate)
storage temp.: 2-8°C
solubility: chloroform: soluble25mg/mL, clear, yellow
pka: 6.16±0.30(Predicted)
form: Crystalline Powder
color: Beige to light brown
BRN: 1868798
CAS DataBase Reference: 772-33-8(CAS DataBase Reference)
EPA Substance Registry System: Phenol, 2-(bromomethyl)-4-nitro- (772-33-8)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29089990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 162906
Product name: 2-Hydroxy-5-nitrobenzyl bromide
Purity: 90%
Packaging: 5g
Price: $68.9
Updated: 2024/03/01

TCI Chemical

Product number: H0601
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Purity: >95.0%(T)
Packaging: 5g
Price: $147
Updated: 2024/03/01

TRC

Product number: H950893
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Packaging: 5g
Price: $45
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK247575
Product name: 2-Hydroxy-5-nitrobenzyl Bromide
Purity: 95%
Packaging: 5g
Price: $38
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0011683
Product name: 2-HYDROXY-5-NITRO BENZYL BROMIDE
Purity: 95.00%
Packaging: 5G
Price: $830.74
Updated: 2021/12/16

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2-HYDROXY-5-NITROBENZYL BROMIDE Chemical Properties,Usage,Production

Chemical Properties

Beige to yellow crystalline powder

Uses

Reagent for sulfhydryl modification.1

Uses

2-Hydroxy-5-nitrobenzyl bromide is a chemical reagent that reacts with and modifies chemically the tryptophan portion of protein molecules..

Uses

2-Hydroxy-5-nitrobenzyl bromide was used in covalent modification of tryptophan and tryptophan residues in monoclonal immunoglobulin. It was also used as reagent for sulfhydryl modification

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 1448, 1964 DOI: 10.1021/ja01061a045

General Description

2-Hydroxy-5-nitrobenzyl bromide is a protein modifying reagent.

Purification Methods

Crystallise the bromide from *benzene or *benzene/ligroin. It is slightly soluble in EtOH, soluble in *C6H6 and AcOH, and very soluble in ligroin. [Beilstein 6 H 367.]

2-HYDROXY-5-NITROBENZYL BROMIDE Preparation Products And Raw materials

Raw materials

Hydrogen bromide Benzene 4-Nitrophenol Phosphorus tribromide Dimethoxymethane Sulfuric acid

Preparation Products

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2-HYDROXY-5-NITROBENZYL BROMIDE Suppliers

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772-33-8, 2-HYDROXY-5-NITROBENZYL BROMIDERelated Search:

Cresol Cresol o-Cresol 2-METHOXY-5-NITROBENZYL BROMIDE 2-Methyl-4-nitrophenol 3-Nitrobenzyl bromide 2-(BROMOMETHYL)PHENOL 4-AMINO-2-METHYLPHENOL 2-HYDROXY-5-NITROBENZYL BROMIDE Benzyl bromide

KOSHLAND I

KOSHLAND REAGENT

KOSHLAND'S REAGENT

KOSHLAND'S REAGENT I

ALPHA-BROMO-4-NITRO-2-CRESOL

ALPHA-BROMO-4-NITRO-O-CRESOL

2-BROMOMETHYL-4-NITROPHENOL

2-HYDROXY-5-NITROBENZYL BROMIDE

2-(bromomethyl)-4-nitro-pheno

o-Cresol, alpha-bromo-4-nitro-

Phenol, 2-(bromomethyl)-4-nitro-

α-bromo-4-nitro-o-cresol

α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshlands Reagent I

a-Bromo-4-nitro-o-cresol

a-Bromo-4-nitro-o-methylphenol

BETA-1-BROMO-4-NITRO-O-CRESOL

2-Hydroxy-5-nitrobenzyl bromide ,95%

2-Hydroxy-5-nitrobenzyl bromide,α-Bromo-4-nitro-o-cresol, 2-Bromomethyl-4-nitrophenol, Koshland I, Koshland’s Reagent I

alpha-Bromo-4-nitro-o-cresol Koshland's Reagent

2-Hydroxy-5-nitrobenzyl bromide 90%

Koshland's reagent 1

alpha-Bromo-4-nitro-o-cresol,95%

alpha-Bromo-4-nitro-o-cresol,98%

2-Hydroxy-5-nitrobenzylBromide&gt

α-bromo-4-nitro-o-cresol

α-bromo-4-nitro-o-creso

Koshland's Reagent 1

772-33-8

73-1

HOC6H3NO2CH2Br

Building Blocks

BioChemical

Organic Building Blocks

Proteomics and Protein Expression

Protein Modification

Proteomics

Reagents for tryptophan modification

Oxygen Compounds

Phenols

Specific Amino Acid Modification

Building Blocks

C6 to C8

Chemical Synthesis

Organic Building Blocks

Oxygen Compounds

Phenols