ChemicalBook > CAS DataBase List > Alpidem

Alpidem

Product Name
Alpidem
CAS No.
82626-01-5
Chemical Name
Alpidem
Synonyms
ALPIDEM;IMidazo;inanxyl;Ananxyl;Alpidemum;SL-80.0342;SL 80.0342-00;Unii-I93sc245qz;Alpidemum [latin];ALPIDEM USP/EP/BP
CBNumber
CB5241330
Molecular Formula
C21H23Cl2N3O
Formula Weight
404.33
MOL File
82626-01-5.mol
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Alpidem Property

Melting point:
136-138°C
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO: ≥10mg/mL
pka
4.74±0.50(Predicted)
form 
powder
color 
white to tan
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1862
Product name
Alpidem
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$135
Updated
2021/12/16
Sigma-Aldrich
Product number
A1862
Product name
Alpidem
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$522
Updated
2021/12/16
TRC
Product number
A575560
Product name
Alpidem
Packaging
100mg
Price
$1590
Updated
2021/12/16
TRC
Product number
A575560
Product name
Alpidem
Packaging
500mg
Price
$4915
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17325
Product name
Alpidem
Packaging
5mg
Price
$230
Updated
2021/12/16
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Alpidem Chemical Properties,Usage,Production

Description

Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.

Chemical Properties

White to Off-White Solid

Originator

Synthelabo (France)

Uses

A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic

Definition

ChEBI: Alpidem is a member of imidazoles.

brand name

Ananxyl

Biochem/physiol Actions

Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.

Clinical claims and research

Alpidem is an imidazopyridine partial agonist that also shows relative selectivity for the type I benzodiazepine receptor. Studies have shown an anxiolytic effect comparable with the classic benzodiazepines, but with an improved adverse effect profile (Pancheri et al. 1993). It has also been compared with buspirone in patients with generalized anxiety disorder and shown to be more rapidly effective and again to have a more favorable adverse effect profile (Legris et al. 1993). Longer-term studies with alpidem have shown that tolerance does not occur, and no significant problems of withdrawal on discontinuation were found (Chevalier et al. 1993). Alpidem was licensed in France for the treatment of anxiety but has now been suspended because of recent reports of alpidem-induced hepatic dysfunction. The reason for this is unclear, but it may be a reflection of the fact that alpidem also binds to peripheral benzodiazepine receptors, which are present in high density in the liver.

Alpidem Preparation Products And Raw materials

Raw materials

Preparation Products

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Alpidem Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3253
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
22784
Advantage
58
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View Lastest Price from Alpidem manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
Alpidem 82626-01-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-14
Dideu Industries Group Limited
Product
ALPIDEM 82626-01-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-22

82626-01-5, AlpidemRelated Search:


  • ALPIDEM
  • 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-aceta mide
  • 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-α]pyridine-3-acetamide
  • SL 80.0342-00
  • 6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide
  • 6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-A)pyridin-3-acetamid
  • Alpidemum
  • Alpidemum [latin]
  • Imidazo(1,2-A)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-
  • Unii-I93sc245qz
  • 2-(6-Chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetaMide
  • IMidazo
  • inanxyl
  • SL-80.0342
  • Ananxyl
  • 6-Chloro-2-(4-chlorophenyl)-N,N-dipmpylimidazol[1,2-α]pyridine-3-acetamide
  • ALPIDEM USP/EP/BP
  • inhibit,GABA Receptor,Gamma-aminobutyric acid Receptor,Inhibitor,Alpidem,γ-Aminobutyric acid Receptor
  • 82626-01-5
  • C21H23Cl2N3O
  • Pharmaceuticals
  • Aromatics Compounds
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals