4-Methylhistamine dihydrochloride

Product Name: 4-Methylhistamine dihydrochloride
CAS No.: 36376-47-3
Chemical Name: 4-Methylhistamine dihydrochloride
Synonyms: SKF-71517;4-Methylhistamine di;4-Methylhistamine DiHCl;4-METHYLHISTAMINE DIHYDROCHLORIDE;5-Methylhistamine dihydrochloride;4-Methylhistamine (hydrochloride);Methylhistamine dihydrochloride, 4-;2-(4-methyl-1H-imidazol-5-yl)ethanamine;5-Methyl-1H-imidazole-4-ethanamine dihydrochloride;4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
CBNumber: CB9838358
Molecular Formula: C6H14Cl2N3
Formula Weight: 199.10146
MOL File: 36376-47-3.mol

More

Less

4-Methylhistamine dihydrochloride Property

Melting point:: 231-233℃ (ethanol )
storage temp.: Desiccate at RT
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
color: White to Pale Beige
Water Solubility: Soluble to 50 mM in water

More

Less

Safety

HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Tocris

Product number: 2342
Product name: 4-Methylhistaminedihydrochloride
Packaging: 10
Price: $216
Updated: 2021/12/16

Tocris

Product number: 2342
Product name: 4-Methylhistaminedihydrochloride
Packaging: 50
Price: $908
Updated: 2021/12/16

More

Less

4-Methylhistamine dihydrochloride Chemical Properties,Usage,Production

Description

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

Uses

Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.

Biological Activity

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

storage

Desiccate at RT

References

[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.

4-Methylhistamine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-Methylhistamine dihydrochloride Suppliers

Canada 1 China 30 Germany 2 India 1 South Korea 1 The Netherlands 1 United Kingdom 1 United States 9 Global 46

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1830
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58851090 13611564524
Fax: (6)02557626880
Email: lwan@aikonchem.com
Country: China
ProdList: 15951
Advantage: 58

Chengdu Feibai Pharmaceutical Co., Ltd.

Tel: 028-84641798 18782128315
Email: 3302391190@qq.com
Country: China
ProdList: 9197
Advantage: 55

Henan Alfa Chemical Co., Ltd

Tel: +86-18339805032; +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 13227
Advantage: 58

36376-47-3, 4-Methylhistamine dihydrochlorideRelated Search:

Alpidem (S)-4,5,6,7-Tetrahydro-3-phenylmethyl-3H-imidazo[4,5-c]pyridine-6-carboxylic acid dihydrochloride 5-amino-4,5,6,7-tetrahydrobenzimidazole 4,5,6,7-TETRAHYDRO-1H-IMIDAZOL[4,5-C]-PYRIDINE DIHYDROCHLORIDE 4-Methylhistamine dihydrochloride 2-METHYL-4,5,6,7-TETRAHYDRO-3H-IMIDAZO[4,5-C]PYRIDINE DIHYDROCHLORIDE (+/-)-5-AMINO-4,5,6,7-TETRAHYDROBENZOIMIDAZOLE DIHYDROCHLORIDE (r)(-)-α-methylhistamine dihydrochloride,R(-)-ALPHA-METHYLHISTAMINE DIHYDROCHLORIDE,(R)-(-)-A-methylhistamine*dihydrochloride β-Methylhistamine dihydrochloride 2-Methylhistamine dihydrochloride 3-METHYLHISTAMINE DIHYDROCHLORIDE N-ALPHA-METHYLHISTAMINE DIHYDROCHLORIDE,NA-METHYLHISTAMINE DIHYDROCHLORIDE,Methylhistamine dihydrochloride Nalpha- S(+)-α-Methylhistamine dihydrochloride n-Methylhistamine dihydrochloride 1-METHYLHISTAMINE DIHYDROCHLORIDE,1-METHYLHISTAMINE DIHYDROCHLORIDE METABO LITE THAT CROSS METHYLHISTAMINE DIHYDROCHLORIDE, N-ALPHA-[METHYL-3H]- IFLAB-BB F1824-0006 4-(2,4-DICHLORO-PHENYL)-4,5,6,7-TETRAHYDRO-3H-IMIDAZO[4,5-C]PYRIDINE-6-CARBOXYLIC ACID

5-(2-AMINOETHYL)-4-METHYLIMIDAZOLE DIHYDROCHLORIDE

4-METHYLHISTAMINE DIHYDROCHLORIDE

SKF-71517

1H-Imidazole-4-ethanamine, 5-methyl-, dihydrochloride (9ci)

4-(2-Aminoethyl)-5-methylimidazole dihydrochloride

5-Methyl-1H-imidazole-4-ethanamine dihydrochloride

5-Methylhistamine dihydrochloride

Imidazole, 4-(2-aminoethyl)-5-methyl-, dihydrochloride

2-(4-methyl-1H-imidazol-5-yl)ethanamine dihydrochloride

2-(5-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride

2-(5-Methyl-4-imidazolyl)ethylamine dihydrochloride

2-(4-methyl-1H-imidazol-5-yl)ethanamine

4-Methylhistamine (hydrochloride)

4-Methylhistamine DiHCl

Methylhistamine dihydrochloride, 4-

4-Methylhistamine di

36376-47-3

Histamine receptor

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals