4-Methylhistamine dihydrochloride

Product Name: 4-Methylhistamine dihydrochloride
CAS No.: 36376-47-3
Chemical Name: 4-Methylhistamine dihydrochloride
Synonyms: SKF-71517;4-Methylhistamine di;4-Methylhistamine DiHCl;4-METHYLHISTAMINE DIHYDROCHLORIDE;5-Methylhistamine dihydrochloride;4-Methylhistamine (hydrochloride);Methylhistamine dihydrochloride, 4-;2-(4-methyl-1H-imidazol-5-yl)ethanamine;5-Methyl-1H-imidazole-4-ethanamine dihydrochloride;4-(2-Aminoethyl)-5-methylimidazole dihydrochloride
CBNumber: CB9838358
Molecular Formula: C6H14Cl2N3
Formula Weight: 199.10146
MOL File: 36376-47-3.mol

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4-Methylhistamine dihydrochloride Property

Melting point:: 231-233℃ (ethanol )
storage temp.: Desiccate at RT
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
form: Solid
color: White to Pale Beige
Water Solubility: Soluble to 50 mM in water

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 23761
Product name: 4-Methylhistamine (hydrochloride)
Purity: ≥95%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Tocris

Product number: 2342
Product name: 4-Methylhistaminedihydrochloride
Packaging: 10
Price: $216
Updated: 2021/12/16

Tocris

Product number: 2342
Product name: 4-Methylhistaminedihydrochloride
Packaging: 50
Price: $908
Updated: 2021/12/16

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4-Methylhistamine dihydrochloride Chemical Properties,Usage,Production

Description

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders.

Uses

Histamine H2 receptor agonist, antagonist and antineoplastic agent on the in vitro growth of peripheral blood CFU-GM from normal individuals and HL-60 leukemia cells.

Biological Activity

4-Methylhistamine dihydrochloride is a potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.

storage

Desiccate at RT

References

[1]. lim hd, van rijn rm, ling p, et al. evaluation of histamine h1-, h2-, and h3-receptor ligands at the human histamine h4 receptor: identification of 4-methylhistamine as the first potent and selective h4 receptor agonist. journal of pharmacology and experimental therapeutics, 2005, 314(3): 1310-1321.
[2]. ahmad sf, ansari ma, zoheir kma, et al. regulation of tnf-α and nf-κb activation through the jak/stat signaling pathway downstream of histamine 4 receptor in a rat model of lps-induced joint inflammation. immunobiology, 2015, 220(7): 889-898.

4-Methylhistamine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methylhistamine dihydrochloride Suppliers

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36376-47-3, 4-Methylhistamine dihydrochlorideRelated Search:

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2-(4-methyl-1H-imidazol-5-yl)ethanamine dihydrochloride

2-(5-Methyl-1H-iMidazol-4-yl)ethanaMine dihydrochloride

2-(5-Methyl-4-imidazolyl)ethylamine dihydrochloride

2-(4-methyl-1H-imidazol-5-yl)ethanamine

4-Methylhistamine (hydrochloride)

4-Methylhistamine DiHCl

Methylhistamine dihydrochloride, 4-

4-Methylhistamine di

36376-47-3

Histamine receptor

Amines

Heterocycles

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