Alpidem

Product Name: Alpidem
CAS No.: 82626-01-5
Chemical Name: Alpidem
Synonyms: ALPIDEM;IMidazo;inanxyl;Ananxyl;Alpidemum;SL-80．0342;SL 80.0342-00;Unii-I93sc245qz;Alpidemum [latin];ALPIDEM USP/EP/BP
CBNumber: CB5241330
Molecular Formula: C21H23Cl2N3O
Formula Weight: 404.33
MOL File: 82626-01-5.mol

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Alpidem Property

Melting point:: 136-138°C
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO: ≥10mg/mL
pka: 4.74±0.50(Predicted)
form: powder
color: white to tan

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A1862
Product name: Alpidem
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $522
Updated: 2021/12/16

Sigma-Aldrich

Product number: A1862
Product name: Alpidem
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $135
Updated: 2021/12/16

TRC

Product number: A575560
Product name: Alpidem
Packaging: 100mg
Price: $1590
Updated: 2021/12/16

TRC

Product number: A575560
Product name: Alpidem
Packaging: 500mg
Price: $4915
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17325
Product name: Alpidem
Packaging: 10mg
Price: $368
Updated: 2021/12/16

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Alpidem Chemical Properties,Usage,Production

Description

Alpidem is an imidazopyridine antianxiety agent with anticonvulsant properties. It is claimed to be the first non-benzodiazepine anxiolytic to show selectivity for the omega-1 modulatory site of the GABA, receptors. Alpidem is reported to be superior to buspirone and similar to the benzodiazepines, but is significantly better tolerated with lower abuse potential.

Chemical Properties

White to Off-White Solid

Originator

Synthelabo (France)

Uses

A peripheral benzodiazepine GABAA receptor ligand, a new anxiolytic

Definition

ChEBI: Alpidem is a member of imidazoles.

brand name

Ananxyl

Biochem/physiol Actions

Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR) that is located on the outer mitochondrial membrane and interacts with the mitochondrial permeability transition (MPT) pore. Alpidem is an anxiolytic drug from the imidazopyridine family. Alpidem acts selectively on the α3 receptor subtype and to a lesser extent at the α1 subtype (Kd of 0.33nM and 1.67nM respectively), of the benzodiazepine receptor.

Clinical claims and research

Alpidem is an imidazopyridine partial agonist that also shows relative selectivity for the type I benzodiazepine receptor. Studies have shown an anxiolytic effect comparable with the classic benzodiazepines, but with an improved adverse effect profile (Pancheri et al. 1993). It has also been compared with buspirone in patients with generalized anxiety disorder and shown to be more rapidly effective and again to have a more favorable adverse effect profile (Legris et al. 1993). Longer-term studies with alpidem have shown that tolerance does not occur, and no significant problems of withdrawal on discontinuation were found (Chevalier et al. 1993). Alpidem was licensed in France for the treatment of anxiety but has now been suspended because of recent reports of alpidem-induced hepatic dysfunction. The reason for this is unclear, but it may be a reflection of the fact that alpidem also binds to peripheral benzodiazepine receptors, which are present in high density in the liver.

Alpidem Preparation Products And Raw materials

Raw materials

Oxalyl chloride

Preparation Products

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Alpidem Suppliers

Canada 1 China 31 Europe 2 India 3 United Kingdom 4 United States 13 Global 54

ecochem international chemical broker

Tel: --
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Email: export@ecochem.dk
Country: Europe
ProdList: 6371
Advantage: 66

kemikalieimport

Tel: --
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Email: Sales@kemikalieimport.dk
Country: Europe
ProdList: 6685
Advantage: 47

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View Lastest Price from Alpidem manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Alpidem 82626-01-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Dideu Industries Group Limited

Product: ALPIDEM 82626-01-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-22

82626-01-5, AlpidemRelated Search:

Piracetam Alpidem 2-IMIDAZO[1,2-A]PYRIDIN-3-YLACETAMIDE 4-(4-CHLORO-PHENYL)-5-METHYL-1H-IMIDAZOLE (1H-IMIDAZOL-4-YL)-ACETALDEHYDE N-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIHYDROCHLORIDE 6-CHLORO-2-PHENYL-IMIDAZO[1,2-A]PYRIDINE 2-(2-PHENYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ETHYLAMINE Imidazo[1,2-a]pyridine-3-ethanamine (9CI) 2-(4-CHLORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE 4-Methylhistamine dihydrochloride 6-Chloroimidazo[1,2-a]pyridine, HCl 3-METHYLHISTAMINE DIHYDROCHLORIDE Alpidem-d14 4-methylhistamine N,N-dimethylhistamine Imidazo(1,2-a)pyridine-3-acetamide,2-methyl-

ALPIDEM

6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-aceta mide

6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-α]pyridine-3-acetamide

SL 80.0342-00

6-Chloro-2-(4-chlorophenyl)-N,N-dipropyl-imidazo[1,2-a]pyridine-3-acetamide

6-Chlor-2-(4-chlorphenyl)-N,N-dipropylimidazol(1,2-A)pyridin-3-acetamid

Alpidemum

Alpidemum [latin]

Imidazo(1,2-A)pyridine-3-acetamide, 6-chloro-2-(4-chlorophenyl)-N,N-dipropyl-

Unii-I93sc245qz

2-(6-Chloro-2-(4-chlorophenyl)iMidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetaMide

IMidazo

inanxyl

SL-80．0342

Ananxyl

6-Chloro-2-(4-chlorophenyl)-N，N-dipmpylimidazol[1，2-α]pyridine-3-acetamide

ALPIDEM USP/EP/BP

inhibit,GABA Receptor,Gamma-aminobutyric acid Receptor,Inhibitor,Alpidem,γ-Aminobutyric acid Receptor

82626-01-5

C21H23Cl2N3O

Pharmaceuticals

Aromatics Compounds

Aromatics

Heterocycles

Intermediates & Fine Chemicals