ChemicalBook > CAS DataBase List > (6-BROMO-NAPHTHALEN-2-YL)-METHANOL
(6-BROMO-NAPHTHALEN-2-YL)-METHANOL
- Product Name
- (6-BROMO-NAPHTHALEN-2-YL)-METHANOL
- CAS No.
- 100751-63-1
- Chemical Name
- (6-BROMO-NAPHTHALEN-2-YL)-METHANOL
- Synonyms
- 6-bromo-2-naphthalinol;6-BroMo-2-naphthaleneMethanol;2-NAPHTHALENEMETHANOL, 6-BROMO-;(6-BROMO-NAPHTHALEN-2-YL)-METHANOL
- CBNumber
- CB52451689
- Molecular Formula
- C11H9BrO
- Formula Weight
- 237.09
- MOL File
- 100751-63-1.mol
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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Property
- Melting point:
- 152-153℃
- Boiling point:
- 374.6±17.0 °C(Predicted)
- Density
- 1.544±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DCM, DMSO. DMF, Ethyl Acetate
- form
- Solids
- pka
- 14.15±0.10(Predicted)
- color
- White
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N-Bromosuccinimide Price
TRC
- Product number
- B685935
- Product name
- 6-Bromo-2-naphthalenemethanol
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
Usbiological
- Product number
- 162099
- Product name
- 6-Bromo-2-naphthalenemethanol
- Packaging
- 10g
- Price
- $425
- Updated
- 2021/12/16
TRC
- Product number
- B685935
- Product name
- 6-Bromo-2-naphthalenemethanol
- Packaging
- 100g
- Price
- $605
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0063777
- Product name
- (2-BROMONAPHTHALEN-6-YL)METHANOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.32
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 55062
- Product name
- 6-Bromo-2-naphthalenemethanol
- Packaging
- 25g
- Price
- $725
- Updated
- 2021/12/16
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(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Chemical Properties,Usage,Production
Uses
6-Bromo-2-naphthalenemethanol is an intermediate in the synthesis of Adapalene (A225000), an antiacne agent.
Synthesis
5773-80-8
100751-63-1
General procedure for the synthesis of 6-bromo-2-hydroxymethylnaphthalene from 6-bromo-2-naphthalenecarboxylic acid: To a solution of 6-bromo-2-naphthalenecarboxylic acid (1 g, 3.98 mmol) in tetrahydrofuran (THF, 20 ml) was added a tetrahydrofuran solution of 2M borane dimethyl sulphide (0.53 ml, 5.97 mmol) in batches at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the mixture was cooled to 0°C and the reaction was quenched by addition of methanol (MeOH). Subsequently, the solution was concentrated under reduced pressure. The crude product was purified by column chromatography (using ethyl acetate in heptane as eluent) to afford 6-bromo-2-hydroxymethylnaphthalene (0.4 g, 89% yield). lCMS analysis showed m/z 238 [M + H]+ .
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 267 - 273
[2] Patent: WO2009/130475, 2009, A1. Location in patent: Page/Page column 31-32
[3] Patent: WO2016/40891, 2016, A2. Location in patent: Paragraph 00335
[4] Patent: WO2005/40157, 2005, A2. Location in patent: Page/Page column 83
[5] Patent: WO2016/112284, 2016, A1. Location in patent: Page/Page column 132; 133
(6-BROMO-NAPHTHALEN-2-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (6-BROMO-NAPHTHALEN-2-YL)-METHANOL manufacturers
Shanghai Rlavie Technology Co ltd
- Product
- 6-Bromo-2-naphthylmethanol 100751-63-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-04
Career Henan Chemical Co
- Product
- (6-BROMO-NAPHTHALEN-2-YL)-METHANOL 100751-63-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-02
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