ChemicalBook > CAS DataBase List > PI 828

PI 828

Product Name: PI 828
CAS No.: 942289-87-4
Chemical Name: PI 828
Synonyms: PI 828;PI 828,PI828;LY 294002, 4′-NH2;PI-828, 10 mM in DMSO;LY 294002, 4′-NH₂;LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem;8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one;8-(4-Aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one;8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one;2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
CBNumber: CB52455753
Molecular Formula: C19H18N2O3
Formula Weight: 322.36
MOL File: 942289-87-4.mol

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PI 828 Property

Boiling point:: 534.2±50.0 °C(Predicted)
Density: 1.316±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble
pka: 4.14±0.10(Predicted)
form: Off-white solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 440206
Product name: LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem<br />A cell-permeable LY 294002 4'-amino derivative with enhanced potency against p110α/β/δ/γ.
Packaging: 5mg
Price: $251
Updated: 2023/01/07

Cayman Chemical

Product number: 21811
Product name: PI-828
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 21811
Product name: PI-828
Purity: ≥98%
Packaging: 5mg
Price: $135
Updated: 2024/03/01

Cayman Chemical

Product number: 21811
Product name: PI-828
Purity: ≥98%
Packaging: 10mg
Price: $235
Updated: 2024/03/01

Tocris

Product number: 2814
Product name: PI828
Purity: ≥98%(HPLC)
Packaging: 1
Price: $106
Updated: 2021/12/16

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PI 828 Chemical Properties,Usage,Production

Definition

ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones.

General Description

A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC₅₀ in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.

Biological Activity

PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase.

storage

Store at +4°C

PI 828 Preparation Products And Raw materials

Raw materials

Preparation Products

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942289-87-4, PI 828Related Search:

Phenyl carbamate LY 294002 Hydrochloride 2-(Dimethylamino)-8-phenyl-4H-1-benzopyran-4-one PI 828 4H-1-Benzopyran-4-one, 2-(diethylamino)- 2-(Diethylamino)-8-phenyl-4H-1-benzopyran-4-one 2-(Etilmetilammino)-8-fenilcromone [Italian]

PI 828

2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one

8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one

LY 294002, 4′-NH2

8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one

LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem

PI 828,PI828

4H-1-Benzopyran-4-one, 8-(4-aminophenyl)-2-(4-morpholinyl)-

8-(4-Aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one

PI-828, 10 mM in DMSO

LY 294002, 4′-NH<sub>2</sub>

942289-87-4