ChemicalBook > CAS DataBase List > 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

Product Name
3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
CAS No.
66655-67-2
Chemical Name
3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
Synonyms
3,4-Dihydro-1H-quizolin-2-one;3,4-DIHYDROQUINAZOLIN-2(1H)-ONE;3,4-Dihydro-2(1H)-quinazolinone;3,4-DIHYDRO-1H-QUINAZOLIN-2-ONE;2(1H)-Quinazolinone, 3,4-dihydro-;1,2,3,4-tetrahydroquinazolin-2-one
CBNumber
CB52463929
Molecular Formula
C8H8N2O
Formula Weight
148.16
MOL File
66655-67-2.mol
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3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Property

Melting point:
241-242℃
Boiling point:
257℃
Density 
1.19
Flash point:
120℃
storage temp. 
Sealed in dry,Room Temperature
pka
12?+-.0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D456150
Product name
3,4-Dihydroquinazolin-2(1H)-one
Packaging
10mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
2076AJ
Product name
3,4-Dihydro-1H-quinazolin-2-one
Packaging
250mg
Price
$315
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0298300
Product name
3,4-DIHYDRO-1H-QUINAZOLIN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$498.63
Updated
2021/12/16
AK Scientific
Product number
2076AJ
Product name
3,4-Dihydro-1H-quinazolin-2-one
Packaging
5g
Price
$3164
Updated
2021/12/16
J&W Pharmlab
Product number
70R0384
Product name
3,4-Dihydro-1H-quinazolin-2-one
Purity
96%
Packaging
1g
Price
$549
Updated
2021/12/16
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3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Chemical Properties,Usage,Production

Synthesis

4403-69-4

13939-06-5

66655-67-2

The general procedure for the synthesis of 3,4-dihydro-1H-quinazolin-2-one from 2-aminobenzylamine and molybdenum hexacarbonyl was as follows: the reaction was carried out in a two-chamber system. First, 2-aminobenzylamine, Pd(OAc)2 (0.05 eq.) and Cu(OAc)2 (0.5 eq.) were added to the reaction chamber and dissolved in 1,4-dioxane (2 mL). In a CO chamber, Mo(CO)6 (200 mg) was dissolved in 1,4-dioxane (2 mL). Subsequently, 1,8-diazabicyclo[5.4.0]undec-7-ene was added to the system. The two-compartment system was placed in a Dry-Syn heating block and heated to 95°C for the reaction. Upon completion of the reaction, the reaction mixture was filtered through a short silica gel plug and subsequently purified by fast column chromatography.

References

[1] Molecules, 2017, vol. 22, # 10,

3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-DIHYDROQUINAZOLIN-2(1H)-ONE Suppliers

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66655-67-2, 3,4-DIHYDROQUINAZOLIN-2(1H)-ONERelated Search:

2,4-DIHYDROXY-6-NITROQUINAZOLINE 6-Chloroquinazoline-2,4(1H,3H)-dione Ketanserin 6-BROMO-2,4(1H,3H)-QUINAZOLINEDIONE KETANSERIN TARTRATE 3-(2-CHLOROETHYL)-2,4(1H,3H)-QUINAZOLINEDIONE Benzoyleneurea 6-AMINO-1H-QUINAZOLINE-2,4-DIONE 3,4-DIHYDRO-3-METHYL-2(1H)-QUINAZOLINONE 3-PHENYL-2,4(1H,3H)-QUINAZOLINEDIONE 6-bromo-3-ethyl-2,4(1H,3H)-quinazolinedione 1,3-dimethyl-2,4-(1H,3H)-quinazolinedione 6-bromo-3-phenyl-2,4(1H,3H)-quinazolinedione 3-(2-Hydroxyethyl)-2,4-(1H,3H)-quinazoline-dione 6,8-DINITRO-2,4-(1H,3H)QUINAZOLINEDIONE 3-AMINO-1H-QUINAZOLINE-2,4-DIONE KETANSERIN HCL, [ETHYLENE-3H]- 7-azidoketanserin

  • 3,4-DIHYDRO-1H-QUINAZOLIN-2-ONE
  • 3,4-Dihydro-2(1H)-quinazolinone
  • 3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
  • 1,2,3,4-tetrahydroquinazolin-2-one
  • 3,4-Dihydro-1H-quizolin-2-one
  • 2(1H)-Quinazolinone, 3,4-dihydro-
  • 66655-67-2
  • aniline