2-Bromo-5-trifluoromethoxypyridine
- Product Name
- 2-Bromo-5-trifluoromethoxypyridine
- CAS No.
- 888327-36-4
- Chemical Name
- 2-Bromo-5-trifluoromethoxypyridine
- Synonyms
- Lasmiditan Impurity 41;2-Bromo-5-(trifluoromethoxy);2-Bromo-5-trifluoromethoxypyridine;Pyridine,2-bromo-5-(trifluoromethoxy)-
- CBNumber
- CB52470062
- Molecular Formula
- C6H3BrF3NO
- Formula Weight
- 241.99
- MOL File
- 888327-36-4.mol
2-Bromo-5-trifluoromethoxypyridine Property
- Boiling point:
- 63-66 °C(Press: 11 Torr)
- Density
- 1.737±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.55±0.10(Predicted)
- form
- liquid
- color
- Clear, almost colourless
- InChI
- InChI=1S/C6H3BrF3NO/c7-5-2-1-4(3-11-5)12-6(8,9)10/h1-3H
- InChIKey
- RKXYQQVLVNEAFB-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=C(OC(F)(F)F)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- MNO000171
- Product name
- 2-Bromo-5-(trifluoromethoxy)pyridine
- Packaging
- 1g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- HCH0363275
- Product name
- 2-BROMO-5-(TRIFLUOROMETHOXY)PYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.54
- Updated
- 2021/12/16
- Product number
- PC421021
- Product name
- 2-Bromo-5-(trifluoromethoxy)pyridine
- Packaging
- 5g
- Price
- $548
- Updated
- 2021/12/16
- Product number
- 4H07-9-41
- Product name
- 2-Bromo-5-(trifluoromethoxy)pyridine
- Packaging
- 5G
- Price
- $877
- Updated
- 2021/12/16
- Product number
- PC421021
- Product name
- 2-Bromo-5-(trifluoromethoxy)pyridine
- Packaging
- 500mg
- Price
- $92
- Updated
- 2021/12/16
2-Bromo-5-trifluoromethoxypyridine Chemical Properties,Usage,Production
Synthesis
1206972-45-3
888327-36-4
General procedure for the synthesis of 2-bromo-5-trifluoromethoxypyridine: 2-chloro-5-(trifluoromethoxy)pyridine (6, 7.0 g, 35.4 mmol) and bromotrimethylsilane (10.8 g, 9.3 mL, 70.8 mmol, 2 eq.) were dissolved in propionitrile (35 mL) and heated to reflux for 24 hours. The reaction process was monitored by gas chromatography (GC) to confirm 100% conversion. Upon completion of the reaction, the mixture was vacuum distilled to afford pure 2-bromo-5-trifluoromethoxypyridine (31, 7.0 g, 28.7 mmol, 81% yield) as a colorless oil. Boiling point: 63-66°C (14 mbar). NMR data: 1H NMR (CDCl3, 300 MHz): δ= 8.34 (d, J = 2.8 Hz, 1H), 7.56 (d, J = 8.7 Hz, 1H), 7.45 (dd, J = 8.7, 2.8 Hz, 1H). 19F NMR (CDCl3, 282 MHz): δ= -58.8. 13C NMR (CDCl3, 75 MHz): δ= 145.6, 143.1, 139.2, 131.4, 129.0, 120.1 (q, J = 260 Hz). Elemental analysis: C6H3BrF3NO (molecular weight 241) Calculated value (%): C 29.78, H 1.25, N 5.79; measured value: C 29.96, H 1.41, N 5.64.
References
[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 38-39
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
2-Bromo-5-trifluoromethoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-5-trifluoromethoxypyridine Suppliers
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- Fax
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- sales@ajchem.in
- Country
- India
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View Lastest Price from 2-Bromo-5-trifluoromethoxypyridine manufacturers
- Product
- 2-Bromo-5-trifluoromethoxypyridine 888327-36-4
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14