2-Fluorobenzene-1,4-diol
- Product Name
- 2-Fluorobenzene-1,4-diol
- CAS No.
- 55660-73-6
- Chemical Name
- 2-Fluorobenzene-1,4-diol
- Synonyms
- Fluorohydroquinone;2-Fluorohydroquinone;o-Fluorohydroquinone;o-Fluorine hydroquinone;2-Fluorobenzene-1,4-diol;2-Fluoro-4-hydroxyphenol;2-Fluoro-1,4-benzenediol;1,4-Benzenediol, 2-fluoro-
- CBNumber
- CB52475926
- Molecular Formula
- C6H5FO2
- Formula Weight
- 128.1
- MOL File
- 55660-73-6.mol
2-Fluorobenzene-1,4-diol Property
- Melting point:
- 121-125℃
- Boiling point:
- 259℃
- Density
- 1.415
- Flash point:
- 111℃
- storage temp.
- 2-8°C
- pka
- 9.42±0.18(Predicted)
- Appearance
- Brown to reddish brown Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38-52/53
- Safety Statements
- 26-61
- WGK Germany
- 3
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC905264
- Product name
- 2-Fluorobenzene-1,4-diol
- Purity
- 95%
- Packaging
- 5g
- Price
- $224
- Updated
- 2021/12/16
- Product number
- PC905264
- Product name
- 2-Fluorobenzene-1,4-diol
- Purity
- 95%
- Packaging
- 10g
- Price
- $359
- Updated
- 2021/12/16
- Product number
- V2384
- Product name
- Fluorohydroquinone
- Packaging
- 5g
- Price
- $410
- Updated
- 2021/12/16
- Product number
- V2384
- Product name
- Fluorohydroquinone
- Packaging
- 10g
- Price
- $651
- Updated
- 2021/12/16
- Product number
- HCH0066608
- Product name
- FLUOROHYDROQUINONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $660.95
- Updated
- 2021/12/16
2-Fluorobenzene-1,4-diol Chemical Properties,Usage,Production
Uses
Reactant for:• ;Regioselective propanoylation mediated by Candida lipase B in organic solvents1
Uses
Reactant for:
- Regioselective propanoylation mediated by Candida lipase B in organic solvents
Synthesis
367-12-4
55660-73-6
General procedure for the synthesis of 2-fluoro-1,4-benzenediol from 2-fluorophenol: 2-fluorophenol (5.6 g, 50.0 mmol) was dissolved in 6% aqueous NaOH (200 mL), and solid potassium persulfate (13.5 g, 50.0 mmol) was added in batches over a 10-minute period with stirring, and the reaction solution changed to a dark color. The reaction mixture was stirred overnight at room temperature and subsequently concentrated under reduced pressure to about 100 mL. after cooling to 0 °C, it was neutralized with concentrated HCl to pH 6.5 and extracted once with ether (100 mL). The organic phase was dried over MgSO4 and concentrated under reduced pressure, and the unreacted 2.0 g of 2-fluorophenol was isolated by fast silica gel column chromatography using hexane/ethyl acetate (V/V 6:1) as eluent.The aqueous phase was acidified with concentrated HCl (50 mL), refluxed for 1 hr, and then concentrated under reduced pressure to ca. 50 mL.The inorganic salts were precipitated by the addition of acetone (100 mL), and removed by filtration. The filtrate was dried by rotary evaporator and the dark residue dissolved in acetone was adsorbed onto silica gel (10 g). After drying, column chromatography (hexane/ethyl acetate 3:1) was carried out to give the product 2.2 g as a white solid, melting point 120-121 °C, yield 52%, Rf 0.30 (hexane solution of 20% EtOAc).1H NMR (300 MHz, CDCl3): δ 6.51-6.56 (m, 1H), 6.64-6.69 (m, 1H). 6.85-6.92 (m, 1H), 4.77 (brs, 2H, 2×OH).EI-MS calculated value C6H5FO2 128 (M+), measured value 129 (M+1)+, 128 (M+).
References
[1] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 72 - 83
[2] Journal of the Chemical Society. Perkin Transactions 1, 2002, # 23, p. 2719 - 2728
[3] Tetrahedron, 2014, vol. 71, # 23, p. 3915 - 3923
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View Lastest Price from 2-Fluorobenzene-1,4-diol manufacturers
- Product
- 2-Fluorobenzene-1,4-diol 55660-73-6
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12
- Product
- 2-Fluorobenzene-1,4-diol 55660-73-6
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 97-99.9%
- Supply Ability
- 20kgs/week
- Release date
- 2019-11-08