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Thiamet G Discontinued

Product Name
Thiamet G Discontinued
CAS No.
1009816-48-1
Chemical Name
Thiamet G Discontinued
Synonyms
CS-1700;Thiamet G;Thiamet H;Thiamet G - Bio-X ?;Thiamet G (Thiamet-G);Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G, 10 mM in DMSO;Thiamet G_x000b_Discontinued;Thiamet G, O-GlcNAcase inhibitor
CBNumber
CB52485666
Molecular Formula
C9H16N2O4S
Formula Weight
248.3
MOL File
1009816-48-1.mol
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Thiamet G Discontinued Property

Boiling point:
483.2±55.0 °C(Predicted)
Density 
1.74±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: ≥5mg/mL at warmed to 60°C
form 
powder
pka
13.17±0.70(Predicted)
color 
white to beige
optical activity
[α]/D -21 to -26°, c = 0.3 in methanol
Water Solubility 
H2O: ≥5mg/mL atwarmed to 60°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI
InChI=1S/C9H16N2O4S/c1-2-10-9-11-5-7(14)6(13)4(3-12)15-8(5)16-9/h4-8,12-14H,2-3H2,1H3,(H,10,11)/t4-,5-,6-,7-,8-/m1/s1
InChIKey
PPAIMZHKIXDJRN-UKPHHSARSA-N
SMILES
S1[C@@]2([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@@]2([H])N=C1NCC
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0244
Product name
Thiamet G
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0244
Product name
Thiamet G
Purity
≥98% (HPLC)
Packaging
25mg
Price
$493.05
Updated
2025/07/31
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
5mg
Price
$89
Updated
2024/03/01
Cayman Chemical
Product number
13237
Product name
Thiamet G
Purity
≥97%
Packaging
10mg
Price
$133
Updated
2024/03/01
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Thiamet G Discontinued Chemical Properties,Usage,Production

Description

Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki?= 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and?in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1?Stabilizes tau against aggregation and slows neurodegeneration.2?Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3?Elevates soluble tau species and reduces tauopathy in mouse models.4?Active?in vivo?and blood brain barrier permeable.

Uses

A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer''s agent.

Uses

As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological

Biochem/physiol Actions

Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.

in vivo

Thiamet G (500 mg/kg/d) increases global and tau O-GlcNAc and reduces neurodegeneration. Thiamet G-treated group has 1.4-fold more motor neurons and hinders tau-driven neurodegeneration within this transgenic model. Thiamet G treatment therefore has no detectable effect on mice lacking the P301L transgene, indicating that prevention of neurodegeneration and weight loss is mediated by Thiamet G treatment only in the context of the P301L transgene. In Thiamet G-treated mice, the O-GlcNAc increases in the brain and spinal cord tissues[1].
Thiamet G (20 mg/kg, i.p.) increases O-GlcNAc levels in brain, liver, and knee of the C57BL/6 mice in a dose-dependent manner[2].

storage

Store at -20°C

References

[1] SCOTT A YUZWA. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo[J]. Nature chemical biology, 2008, 4 8: 483-490. DOI:10.1038/nchembio.96
[2] SCOTT A YUZWA. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation[J]. Nature chemical biology, 2012, 8 4: 393-399. DOI:10.1038/nchembio.797
[3] SCOTT A YUZWA. Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.[J]. Molecular Neurodegeneration, 2014, 9: 42. DOI:10.1186/1750-1326-9-42
[4] NICHOLAS B HASTINGS. Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice.[J]. ACS Combinatorial Science, 2017: 39. DOI:10.1186/s13024-017-0181-0

Thiamet G Discontinued Preparation Products And Raw materials

Raw materials

Preparation Products

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Thiamet G Discontinued Suppliers

Canada 2 China 134 Germany 1 India 1 United Kingdom 3 United States 16 Global 157
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
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58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Qingdao Vochem Co., Ltd.
Tel
532-88066095 18661779210
Email
vochem@vochem.com
Country
China
ProdList
98
Advantage
60
Goodee Pharma Co., Ltd.
Tel
0512-62956210
Email
yongyan@goodeepharma.com
Country
China
ProdList
132
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
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View Lastest Price from Thiamet G Discontinued manufacturers

Career Henan Chemical Co
Product
Thiamet G Discontinued 1009816-48-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-03-04
Career Henan Chemical Co
Product
Thiamet G 1009816-48-1
Price
US $9.80/KG
Min. Order
1KG
Purity
＞98%HPLC
Supply Ability
20 tons
Release date
2020-02-06

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