Thiamet G Discontinued
- Product Name
- Thiamet G Discontinued
- CAS No.
- 1009816-48-1
- Chemical Name
- Thiamet G Discontinued
- Synonyms
- CS-1700;Thiamet G;Thiamet H;Thiamet G0nDiscontinued;Thiamet G Discontinued ;Thiamet G_x000b_Discontinued;1,2-Dideoxy-2'-ethylamino-a-D-glucopyranoso-[2,1-d]-2'-thiazoline;2-(ethylaMino)-5-(hydroxyMethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-dio;2-(ethylamino)-3aR,6S,7R,7aR-tetrahydro-5R-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol;(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d]thiazole-6,7-diol
- CBNumber
- CB52485666
- Molecular Formula
- C9H16N2O4S
- Formula Weight
- 248.3
- MOL File
- 1009816-48-1.mol
Thiamet G Discontinued Property
- Boiling point:
- 483.2±55.0 °C(Predicted)
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: ≥5mg/mL at warmed to 60°C
- form
- powder
- pka
- 13.17±0.70(Predicted)
- color
- white to beige
- optical activity
- [α]/D -21 to -26°, c = 0.3 in methanol
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- PPAIMZHKIXDJRN-UKPHHSARSA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0244
- Product name
- Thiamet G
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $127
- Updated
- 2024/03/01
- Product number
- SML0244
- Product name
- Thiamet G
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 13237
- Product name
- Thiamet G
- Purity
- ≥97%
- Packaging
- 1mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 13237
- Product name
- Thiamet G
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 13237
- Product name
- Thiamet G
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $133
- Updated
- 2024/03/01
Thiamet G Discontinued Chemical Properties,Usage,Production
Description
Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki?= 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and?in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1?Stabilizes tau against aggregation and slows neurodegeneration.2?Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3?Elevates soluble tau species and reduces tauopathy in mouse models.4?Active?in vivo?and blood brain barrier permeable.
Uses
A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer''s agent.
Uses
As a potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo, The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological
Biochem/physiol Actions
Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and hippocampus.
storage
Store at -20°C
References
1) Yuzwa?et al. (2008),?A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo; Nat. Chem. Biol.,?4?483 2) Yuzwa?et al. (2012),?Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation; Nat. Chem. Biol.?8?393 3) Yuzwa?et al. (2014),?Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice; Mol. Neurodegener.,?9?42 4) Hastings?et al.?(2017)?Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice;?Mol. Neurodegener.,?12?39
Thiamet G Discontinued Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thiamet G Discontinued manufacturers
- Product
- Thiamet G Discontinued 1009816-48-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-03-04
- Product
- Thiamet G 1009816-48-1
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ＞98%HPLC
- Supply Ability
- 20 tons
- Release date
- 2020-02-06