ChemicalBook > CAS DataBase List > 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole

Product Name
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
CAS No.
303727-31-3
Chemical Name
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
Synonyms
450;L-779;CS-1697;L-779450;L-779450 (L779450);Raf Kinase Inhibitor IV;L-779450, 10 mM in DMSO;L779450, Raf kinase inhibitor;2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol;2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol
CBNumber
CB52489583
Molecular Formula
C20H14ClN3O
Formula Weight
347.8
MOL File
303727-31-3.mol
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2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Property

Boiling point:
579.8±50.0 °C(Predicted)
Density 
1.335±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO:44.67(Max Conc. mg/mL);128.44(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);86.26(Max Conc. mM)
DMF:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.35(Max Conc. mM)
Ethanol:2.0(Max Conc. mg/mL);5.75(Max Conc. mM)
pka
8.09±0.10(Predicted)
form 
Powder
color 
Light yellow to yellow
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
553014
Product name
Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem
Packaging
1MG
Price
$155
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1338
Product name
L-779450
Purity
≥98% (HPLC)
Packaging
25MG
Price
$492
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1338
Product name
L-779450
Purity
≥98% (HPLC)
Packaging
5MG
Price
$118
Updated
2022/05/15
Cayman Chemical
Product number
17807
Product name
L-779,450
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17807
Product name
L-779,450
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
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2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Chemical Properties,Usage,Production

Uses

L-779450 is a potent and selective B-Raf kinase inhibitor with a Kd of 2.4 nM.

Definition

ChEBI: 2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol is a member of imidazoles.

Biological Activity

Potent, ATP-competitive Raf kinase inhibitor (IC 50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38 α , GSK3 β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

IC 50

B-Raf: 2.4 nM (Kd)

References

[1] Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6. DOI:10.1016/j.bmcl.2008.06.070
[2] Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17(9):1765-82. DOI:10.1038/sj.leu.2403052
[3] Berger A, et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-440. DOI:10.1038/jid.2013.347

2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole Suppliers

Canada 1 China 89 India 1 United Kingdom 1 United States 15 Global 107
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View Lastest Price from 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole manufacturers

Dideu Industries Group Limited
Product
2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole 303727-31-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-27
Career Henan Chemical Co
Product
2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol 303727-31-3
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

303727-31-3, 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazoleRelated Search:

2-HYDROXYACETOPHENONE 3'-Hydroxyacetophenone 2'-Hydroxyacetophenone Dihydroxybenzoic acid

  • 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole
  • L-779450
  • 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol
  • 4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(4-pyridyl)-1H-iMidazole
  • Phenol, 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-iMidazol-5-yl]-
  • 2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-iMidazol-4-yl)phenol
  • 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol
  • 4-(4-Chloro-3-hydroxyphenyl)-2-phenyl-5-(pyridin-4-yl)-1H-iMidazole
  • 2-chloro-5-(2-phenyl-4-(pyridin-4-yl)-1H-imidazol-5-yl)phenol
  • 450
  • L-779
  • CS-1697
  • 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole ISO 9001：2015 REACH
  • Raf Kinase Inhibitor IV
  • L779450, Raf kinase inhibitor
  • L-779450, 10 mM in DMSO
  • L-779450 (L779450)
  • 303727-31-3
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals