tert-butyl azetidin-3-ylmethyl(methyl)carbamate

Product Name: tert-butyl azetidin-3-ylmethyl(methyl)carbamate
CAS No.: 1053655-53-0
Chemical Name: tert-butyl azetidin-3-ylmethyl(methyl)carbamate
Synonyms: 3-(N-Boc-Methylaminomethy...;3-[Boc(methyl)aminomethyl]azetidine,95%;3-[Boc(Methyl)aMinoMethyl]azetidine, 95%;N-Boc-1-(3-azetidinyl)-N-methylmethanamine;tert-butyl azetidin-3-ylmethyl(methyl)carbamate;tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate;1,1-Dimethylethyl N-(3-azetidinylmethyl)-N-methylcarbamate;N-(3-Azetidinylmethyl)-N-methylcarbamic acid tert-butyl ester;N-(3-azetidinylMethyl)-n-Methyl-carbaMic acid 1,1-diMethylethyl ester;Carbamic acid, N-(3-azetidinylmethyl)-N-methyl-, 1,1-dimethylethyl ester
CBNumber: CB52490295
Molecular Formula: C10H20N2O2
Formula Weight: 200.28
MOL File: 1053655-53-0.mol

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tert-butyl azetidin-3-ylmethyl(methyl)carbamate Property

Boiling point:: 267℃
Density: 1.012
Flash point:: 116℃
storage temp.: 2-8°C(protect from light)
pka: 10.86±0.40(Predicted)

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H60310
Product name: 3-[Boc(methyl)aminomethyl]azetidine, 95%
Packaging: 250mg
Price: $214
Updated: 2023/06/20

Alfa Aesar

Product number: H60310
Product name: 3-[Boc(methyl)aminomethyl]azetidine, 95%
Packaging: 1g
Price: $612
Updated: 2023/06/20

TRC

Product number: B789533
Product name: tert-ButylAzetidin-3-ylmethyl(methyl)carbamate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 059926
Product name: 3-(N-Boc-Methylaminomethyl)azetidine
Purity: 95%
Packaging: 1g
Price: $612
Updated: 2021/12/16

Matrix Scientific

Product number: 059926
Product name: 3-(N-Boc-Methylaminomethyl)azetidine
Purity: 95%
Packaging: 500mg
Price: $475
Updated: 2021/12/16

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tert-butyl azetidin-3-ylmethyl(methyl)carbamate Chemical Properties,Usage,Production

Uses

Tert-butyl azetidin-3-ylmethyl(methyl)carbamate is an important organic reagent that can be used as a building block for the synthesis of tert-butyl ((1-((4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)azetidin-3-yl)methyl)(methyl)carbamate which is an important intermediate of a selective small-molecule PLK inhibitors useful in the treatment of cell proliferative disorders.

Synthesis

A solution of tert-butyl ((1-benzhydrylazetidin-3-yl)methyl)carbamate (6.18 g, 17.53 mmol) in 50 mL of MeOH and 15 mL of EtOAc was purged with argon. Pd/C (10%, 50% in water) (929 mg) was added and the mixture was then purged again with argon and stirred in an H2 atmosphere for 18 h. The reaction was filtered through Ceitte and the filter was washed with EtOAc and MeOH, The resulting solvent was evaporated to dryness, providing 5.66 g of a mixture of tert-butyl azetidin-3-ylmethyl(methyl)carbamate together with one equivalent of diphenylmethane. The pure product tert-butyl azetidin-3-ylmethyl(methyl)carbamate was obtained after further purification.

tert-butyl azetidin-3-ylmethyl(methyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl azetidin-3-ylmethyl(methyl)carbamate Suppliers

China 34 Germany 1 India 1 United States 7 Global 43

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1053655-53-0, tert-butyl azetidin-3-ylmethyl(methyl)carbamateRelated Search:

tert-butyl azetidin-3-ylmethyl(methyl)carbamate

3-(N-Boc-Methylaminomethy...

3-[Boc(Methyl)aMinoMethyl]azetidine, 95%

N-(3-Azetidinylmethyl)-N-methylcarbamic acid tert-butyl ester

N-(3-azetidinylMethyl)-n-Methyl-carbaMic acid 1,1-diMethylethyl ester

tert-butyl N-(azetidin-3-ylmethyl)-N-methylcarbamate

Carbamic acid, N-(3-azetidinylmethyl)-N-methyl-, 1,1-dimethylethyl ester

3-[Boc(methyl)aminomethyl]azetidine,95%

N-Boc-1-(3-azetidinyl)-N-methylmethanamine

1,1-Dimethylethyl N-(3-azetidinylmethyl)-N-methylcarbamate

1053655-53-0