ChemicalBook > CAS DataBase List > (R)-2-Aminomethyl-4-boc-morpholine

(R)-2-Aminomethyl-4-boc-morpholine

Product Name: (R)-2-Aminomethyl-4-boc-morpholine
CAS No.: 1174913-80-4
Chemical Name: (R)-2-Aminomethyl-4-boc-morpholine
Synonyms: (R)-4-Boc-2-aminomethylmorpholine;(R)-2-Aminomethyl-4-boc-morpholine;(R)-N-BOC-2-AMINOMETHYLMORPHOLINE OXALATE;tert-Butyl-2-(aminomethyl)morpholin-4-carboxylat;(R)-tert-butyl 2-aMinoMethylMorpholine-4-carboxylate;tert-Butyl-(2R)-2-(aminomethyl)morpholin-4-carboxylat;tert-butyl (2R)-2-(aminomethyl)morpholine-4-carboxylate;(R)-2-(Aminomethyl)morpholine-4-carboxylic acid tert-butyl ester;4-Morpholinecarboxylic acid, 2-(aMinoMethyl)-, 1,1-diMethylethyl ester, (2R)-
CBNumber: CB52490866
Molecular Formula: C10H20N2O3
Formula Weight: 216.28
MOL File: 1174913-80-4.mol

Less

(R)-2-Aminomethyl-4-boc-morpholine Property

Boiling point:: 311℃
Density: 1.078
Flash point:: 142℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 9.37±0.29(Predicted)
Appearance: Colorless to off-white Solid-Liquid Mixture
optical activity: 24.83°(C=0.01g/ml MEOH)
InChI: InChI=1S/C10H20N2O3/c1-10(2,3)15-9(13)12-4-5-14-8(6-11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1
InChIKey: MTMBHUYOIZWQAJ-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCO[C@H](CN)C1

Less

Safety

HS Code: 2934999090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

TRC

Product number: A635040
Product name: (R)-2-Aminomethyl-4-boc-morpholine
Packaging: 100mg
Price: $285
Updated: 2021/12/16

Activate Scientific

Product number: AS3653-A
Product name: (R)-4-Boc-2-(aminomethyl)morpholine
Purity: 95+% ee
Packaging: 1g
Price: $560
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-R32
Product name: (R)-4-Boc-2-(aminomethyl)morpholine
Packaging: 500mg
Price: $695
Updated: 2021/12/16

Apolloscientific

Product number: OR451233
Product name: (R)-4-Boc-2-(aminomethyl)morpholine
Packaging: 500mg
Price: $841
Updated: 2021/12/16

AK Scientific

Product number: 2853AA
Product name: (R)-2-Aminomethyl-4-Boc-morpholine
Packaging: 5g
Price: $1072
Updated: 2021/12/16

Less

(R)-2-Aminomethyl-4-boc-morpholine Chemical Properties,Usage,Production

Synthesis

1132683-15-8

1174913-80-4

Step 3. tert-Butyl (S)-2-(azidomethyl)morpholine-4-carboxylate (1.0 eq.) was dissolved in ethanol (0.1 M) under argon protection. To this solution was added Pd/C catalyst (0.20 eq.), followed by three evacuations of the reaction system and replacement with hydrogen gas. The reaction mixture was stirred at room temperature and under atmospheric pressure hydrogen atmosphere (using a hydrogen balloon) for 24 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and the reaction system was replaced with argon. The reaction mixture was filtered through a diatomaceous earth pad and concentrated under reduced pressure to afford tert-butyl (R)-2-(aminomethyl)morpholine-4-carboxylate as a white solid in 91% yield.LCMS analysis showed (m/z) [M+H]+ = 217.1 and retention time (Rt) = 0.43 min.

References

[1] Patent: US2014/275003, 2014, A1. Location in patent: Paragraph 0188
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4810 - 4819
[3] Patent: US2015/259350, 2015, A1. Location in patent: Paragraph 0065; 0073
[4] Patent: KR101745741, 2017, B1. Location in patent: Paragraph 0119; 0132

(R)-2-Aminomethyl-4-boc-morpholine Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(R)-2-Aminomethyl-4-boc-morpholine Suppliers

China 70 India 1 United Kingdom 1 United States 12 Global 84

skychemical Co.Ltd

Tel: 021-20960837,QQ1332204249
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 3341
Advantage: 55

ForeChem (Nantong) Technology Co.,Ltd.

Tel: 513-85982855 18921614129
Fax: 051385915507
Email: sales@xianxingpharm.com
Country: China
ProdList: 2986
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Chembon Pharmaceutical Co., Ltd.

Tel: 028-84252981
Fax: +86-28-84252965
Email: sales@chembon.com.cn
Country: China
ProdList: 850
Advantage: 64

Shanghai Sheepchem Co., Ltd.

Tel: +86 (21) 6715-7650
Fax: +86 (21) 6715-7651
Email: sheepchem@163.com
Country: China
ProdList: 994
Advantage: 60

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

EnliPharma Technology Co., Ltd

Tel: 0551-66399836 18955197623
Email: sales@enlipharma.com
Country: China
ProdList: 1876
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828 4008675858
Fax: +86-512-56316826
Email: sales@amateksci.com
Country: China
ProdList: 9874
Advantage: 55

Hygeia (Chengdu) pharmaceutical technique Co., Ltd

Tel: 028-84502008 13568869383
Fax: 028-66476329
Email: sales@hygeiapharm.com
Country: China
ProdList: 296
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Nantong MYBio-pharm. Co., Ltd.

Tel: 0513-85921823 18662920231
Fax: 86-513-85012876
Email: sales@ntminyanmedical.com
Country: China
ProdList: 4108
Advantage: 58

Shanghai Balmxy Pharmaceutical Co., Ltd

Tel: 021-24206007 13764915196
Fax: 86-021-23027023
Email: sales@balmxy.com
Country: China
ProdList: 6874
Advantage: 55

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

Chongqing Acemol Technology Co.,Ltd

Tel: 023-86822659 18611316925
Email: sales@acemol.com
Country: China
ProdList: 993
Advantage: 55

Shanghai Qing Cang Chemical Technology Co., Ltd.

Tel: 00000000000
Fax: -
Email: sales@qingcangchem.com
Country: China
ProdList: 509
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 0519-85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Greenherbs Science and Technology Development Co., Ltd.

Tel: 010-61136123
Fax: +86 (10) 8857-9127
Email: pub02@greenherbs.com.cn
Country: China
ProdList: 4049
Advantage: 58

Chengdu Focus Pharmaceutical Technology Co., Ltd.

Tel: 028-64950838 17340131597
Email: bd-focus@focuspharm.com
Country: China
ProdList: 850
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Deyang Chengchuang Pharmaceutical Technology Co., Ltd.

Tel: 028-66569636 18227172063
Fax: 028-66569636
Email: sales@dyccpharma.com
Country: China
ProdList: 49
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9717
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Yujinpharma(Tianjin) Technology Co.,Ltd.

Tel: 13370351217 kungfu1217@1
Fax: QQ1400885609
Email: kungfu1217@163.com
Country: China
ProdList: 2720
Advantage: 58

Shanghai Benso Pharmaceutical Technology Co., Ltd.

Tel: 15088289376
Email: 248775804@qq.com
Country: China
ProdList: 4995
Advantage: 58

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 021-50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12878
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.

Tel: 15990591583
Fax: qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country: China
ProdList: 6108
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Nantong puyue biomedical Co., Ltd

Tel: 0513-0513-0513-89158300 18014392889
Fax: 0513-89158198
Email: sales@puyerbiopharma.com
Country: China
ProdList: 4956
Advantage: 58

Birdo (Shanghai) Medical Technology Co., Ltd.

Tel: 021-58099077-8041 18601625411
Email: sales@birdotech.com
Country: China
ProdList: 9764
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 9991
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

chemmole

Tel: 400-168-9330 15013243073
Email: 597760450@qq.com
Country: China
ProdList: 2942
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Chengdu Dorher Pharmaceutical CO.,Ltd

Tel: 028-64259743; 19983537320
Email: bd-focus@focuspharm.com
Country: China
ProdList: 682
Advantage: 58

Nanjing Wogni Chemical Co., Ltd.

Tel: 15996452985
Email: foxerhy@163.com
Country: China
ProdList: 4939
Advantage: 58

1174913-80-4, (R)-2-Aminomethyl-4-boc-morpholineRelated Search:

(R)-4-Boc-3-aminomethylmorpholine (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) tert-Butyl 3-oxoazetidine-1-carboxylate Methyl 8-azabicyclo[3.2.1... (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate tert-Butyl (3R)-3-(hydroxymethyl)morpholine-4-carboxylate (R)-4-Boc-broMoMethylMorpholine (R)-N-Boc-2-morpholinecarbaldehyde (S)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid (R)-4-Cbz-3-(aMinoMethyl)Morpholine (R)-4-benzyl-2-hydroxymethylpiperazine 2-Morpholinemethanamine,4-methyl-,(R)-(9CI) (R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine (R)-4-Boc-3-((R)-1-hydroxyethyl)morpholine (R)-4-Cbz-2-(aMinoMethyl)Morpholine (R)-4-Boc-3-carbaMoylMorpholine (R)-4-Boc-2-carbaMoylMorpholine

(R)-N-BOC-2-AMINOMETHYLMORPHOLINE OXALATE

(R)-2-(Aminomethyl)morpholine-4-carboxylic acid tert-butyl ester

4-Morpholinecarboxylic acid, 2-(aMinoMethyl)-, 1,1-diMethylethyl ester, (2R)-

(R)-tert-butyl 2-aMinoMethylMorpholine-4-carboxylate

tert-butyl (2R)-2-(aminomethyl)morpholine-4-carboxylate

(R)-2-Aminomethyl-4-boc-morpholine

(R)-4-Boc-2-aminomethylmorpholine

tert-Butyl-(2R)-2-(aminomethyl)morpholin-4-carboxylat

tert-Butyl-2-(aminomethyl)morpholin-4-carboxylat

1174913-80-4