(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

Product Name: (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
CAS No.: 147266-92-0
Chemical Name: (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
Synonyms: (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;BOC-D-HYP-OH;Boc-D-trans-Hyp-OH;Boc-trans-D-Hyp-OH;trans-Boc-D-Hpy-OH;N-Boc-trans-D-Hyp-OH;BOC-D-PRO(4-HYDROXY)-OH;Prusogliptin Impurity 16;Teneligliptin Impurity 27;BOC-TRANS-4-HYDROXY-D-PROLINE
CBNumber: CB7345548
Molecular Formula: C10H17NO5
Formula Weight: 231.25
MOL File: 147266-92-0.mol

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(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Property

Melting point:: 123°C
Boiling point:: 390.9±42.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 3.80±0.40(Predicted)
form: solid
color: White
optical activity: [α]/D +70°, c = 0.617 g/mL in methanol

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 762067
Product name: N-Boc-trans-4-hydroxy-D-proline
Purity: 97%
Packaging: 1g
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 762067
Product name: N-Boc-trans-4-hydroxy-D-proline
Purity: 97%
Packaging: 500mg
Price: $110
Updated: 2023/06/20

Usbiological

Product number: 265617
Product name: Boc-trans-4-hydroxy-D-proline
Packaging: 250mg
Price: $340
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50595
Product name: Boc-trans-4-hydroxy-D-proline
Packaging: 250mg
Price: $100
Updated: 2021/12/16

chempep

Product number: 180832
Product name: Boc-trans-D-Hyp-OH
Packaging: 5g
Price: $300
Updated: 2021/12/16

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(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

Boc protected Proline derivative.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

51-35-4

147266-92-0

General procedure for the synthesis of N-BOC-trans-4-hydroxy-D-proline from di-tert-butyl dicarbonate and L-hydroxyproline: Step A: Preparation of (4β)-1-Boc-4-hydroxy-L-proline 1. dissolve L-hydroxyproline (5.08 g, 38.77 mmol) in a solvent mixture of 1N NaOH solution (40 mL) and 1,4-dioxane (40 mL). 2. Di-tert-butyl dicarbonate (9.3 g, 42.6 mmol) was added drop-wise to the above solution at 0 °C. 3. The reaction mixture was stirred at room temperature for 8 hours. 4. 4. After completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. 5. The concentrated mixture was acidified with 1N HCl and then extracted with EtOAc. 6. The organic extract was washed with brine, dried over MgSO4 and filtered. 7. Finally, the filtrate was concentrated under vacuum to give N-BOC-trans-4-hydroxy-D-proline (8.84 g, 99% yield). MS [M + H] = 232 (M + 1).

IC 50

Non-cleavable Linker

References

[1] Patent: WO2010/56022, 2010, A2. Location in patent: Page/Page column 21

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Suppliers

Canada 1 China 149 Germany 1 India 6 Japan 2 United Kingdom 2 United States 18 Global 179

J & K SCIENTIFIC LTD.

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China DongFan Chemical Co.,LTD

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View Lastest Price from (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO 147266-92-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO 147266-92-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 147266-92-0
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-07-30

147266-92-0, (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACIDRelated Search:

(2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) tert-Butyl 3-oxoazetidine-1-carboxylate Methyl 8-azabicyclo[3.2.1... (R)-2-Aminomethyl-4-boc-morpholine (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate (2R,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Boc-Hyp-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester (2S,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID N-BOC-TRANS-4-HYDROXY-D-PROLINE METHYL ESTER trans-4-Hydroxy-D-proline BOC-TRANS-HYP-OH,BOC-L-HYP-OH,(2S,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

(2R,4S)-N-Boc-trans-4-hydroxy-D-proline

(2R,4S)-N-Boc-cis-4-hydroxy-D-proline

Boc-D-trans-Hyp-OH

N-Boc-trans-4-hydroxy-D-proline 95+%

(2R,4S)-N-Boc-4-hydroxy-D-proline

(2R,4S)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester

N-Boc-trans-D-Hyp-OH

1-tert-Butoxycarbonyl-(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R-trans)-

Boc-trans-D-Hyp-OH

1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R,4S)-

trans-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid

(2R,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester

Boc-(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid

Boc-trans-4-hydroxy-D-proline≥ 95% (NMR)

BOC-D-PRO(4-HYDROXY)-OH

BOC-D-HYP-OH

BOC-TRANS-4-HYDROXY-D-PROLINE

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

N-T-BOC-TRANS-4-HYDROXY-D-PROLINE

N-ALPHA-T-BUTOXYCARBONYL-D-HYDROXYPROLINE

N-Boc-trans-4-Hydroxy-D-proline

N-BOC-CIS-7-HYDROXY-D-PROLINE

(2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

(Tert-Butoxy)Carbonyl D-trans-Hyp-OH

N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline

(2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylicaci

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID USP/EP/BP

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO

N-tert-Boc-trans-4-Hydroxy-D-proline

(2R,4s)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARB...

trans-Boc-D-Hpy-OH

(2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-car

1-(1,1-Dimethylethyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate

Prusogliptin Impurity 16

N-tert-butoxycarbonyl-D-trans-4- hydroxyproline

Tenteligliptin impurity 2 (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2- carboxylic acid

(2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid/N-tert-butoxycarbonyl-D-trans-4-hydroxyproline

<i>N</i>-Boc-<i>trans</i>-4-hydroxy-<sc>D</sc>-proline

N-Boc-trans-4-hydroxy-D-proline, 97%

Teneligliptin Impurity 27

1-(tert-Butyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate

147266-92-0

C10H17NO8

C10H17F2NO5