tert-Butyl 3-oxoazetidine-1-carboxylate

Product Name: tert-Butyl 3-oxoazetidine-1-carboxylate
CAS No.: 398489-26-4
Chemical Name: tert-Butyl 3-oxoazetidine-1-carboxylate
Synonyms: 1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;N-Boc-Azetidin-3-one;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;N-boc-3-azetidine;1-Boc-3-azetidione;1-Boc-3-acetidinone
CBNumber: CB5282384
Molecular Formula: C8H13NO3
Formula Weight: 171.19
MOL File: 398489-26-4.mol

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tert-Butyl 3-oxoazetidine-1-carboxylate Property

Melting point:: 47-51 °C
Boiling point:: 251.3±33.0 °C(Predicted)
Density: 1.174±0.06 g/cm3(Predicted)
Flash point:: 102 °C
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Sparingly), Dichloromethane (Slightly)
pka: -1.99±0.20(Predicted)
form: Crystalline Powder
color: White to off-white
Sensitive: Moisture Sensitive/Stench
InChI: InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3
InChIKey: VMKIXWAFFVLJCK-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(=O)C1
CAS DataBase Reference: 398489-26-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-39
RIDADR: UN 3335
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696315
Product name: 1-Boc-3-azetidinone
Purity: 97%
Packaging: 1g
Price: $97.1
Updated: 2024/03/01

TCI Chemical

Product number: B3988
Product name: 1-(tert-Butoxycarbonyl)-3-azetidinone
Purity: >98.0%(GC)
Packaging: 1g
Price: $50
Updated: 2024/03/01

TCI Chemical

Product number: B3988
Product name: 1-(tert-Butoxycarbonyl)-3-azetidinone
Purity: >98.0%(GC)
Packaging: 5g
Price: $145
Updated: 2024/03/01

Alfa Aesar

Product number: H50826
Product name: 1-Boc-3-azetidinone, 95%
Packaging: 1g
Price: $201
Updated: 2021/12/16

Alfa Aesar

Product number: H50826
Product name: 1-Boc-3-azetidinone, 95%
Packaging: 250mg
Price: $51.8
Updated: 2021/12/16

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tert-Butyl 3-oxoazetidine-1-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.

Uses

tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

General Description

tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.

Synthesis

The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.

tert-Butyl 3-oxoazetidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 3-oxoazetidine-1-carboxylate Suppliers

Americas 1 Austria 1 Canada 2 China 387 Europe 2 France 1 Germany 5 India 26 Italy 1 Japan 2 South Korea 1 Switzerland 3 United Kingdom 7 United States 45 Global 484

BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015-397-397 15716293042
Fax: 0513-68015394
Email: sales14@btcpharm.com
Country: China
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Advantage: 55

Shanghai Sagachem Co., Ltd.

Tel: 13816115801
Email: raochenaone@126.com
Country: China
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Shanghai Jin Yi Fine Chemical Co.,LTD

Tel: 021-52801082 13918092929
Fax: 021-52803959
Email: jinyi_service@jyfinechem.com
Country: China
ProdList: 48
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Hangzhou Copiore Chemical Co., Ltd.

Tel: 0571-56076030 13757145729
Fax: 0571-56076030
Email: sales@copiore.com
Country: China
ProdList: 226
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Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
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Anhui Jianzhu Biotechnology Co., Ltd.

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Country: China
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Lianhe Aigen Pharmatech Co.,Ltd.

Tel: 18918657159
Email: sales-Aigen@lianhetech.com
Country: China
ProdList: 3006
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Shandong Shenglan Chemical Technology Co. Ltd

Tel: 17806220283
Fax: QQ/wx：9291866
Email: info@samelabs.com
Country: China
ProdList: 66
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

Shanghai Ruiyi Pharmaceutical Technology Co., Ltd

Tel: 021-54711706
Email: sales5@ruiyitech.com
Country: China
ProdList: 82
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View Lastest Price from tert-Butyl 3-oxoazetidine-1-carboxylate manufacturers

PNP Biotech Co. Ltd

Product: Tert-Butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price: US $0.00/KG
Min. Order: 25KG
Purity: 96%
Supply Ability: Inquiry
Release date: 2022-09-16

Nanjing Fred Technology Co., Ltd

Product: Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-29

Shanghai Jinli Pharmaceutical Co.,Ltd

Product: Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price: US $1.00-1.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 30TONS
Release date: 2023-01-31

398489-26-4, tert-Butyl 3-oxoazetidine-1-carboxylateRelated Search:

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3-Oxoazetidine, N-BOC protected 95%

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tert-butyl -3-oxozatidine-1-carboxylate

1-Boc azitidone

398489-26-4

398498-26-4

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Ring Systems

pharmacetical

Heterocycles series

Azetidine

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