ChemicalBook > CAS DataBase List > tert-Butyl 3-oxoazetidine-1-carboxylate

tert-Butyl 3-oxoazetidine-1-carboxylate

Product Name
tert-Butyl 3-oxoazetidine-1-carboxylate
CAS No.
398489-26-4
Chemical Name
tert-Butyl 3-oxoazetidine-1-carboxylate
Synonyms
1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;N-Boc-Azetidin-3-one;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;N-boc-3-azetidine;1-Boc-3-azetidione;1-Boc-3-acetidinone
CBNumber
CB5282384
Molecular Formula
C8H13NO3
Formula Weight
171.19
MOL File
398489-26-4.mol
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tert-Butyl 3-oxoazetidine-1-carboxylate Property

Melting point:
47-51 °C
Boiling point:
251.3±33.0 °C(Predicted)
Density 
1.174±0.06 g/cm3(Predicted)
Flash point:
102 °C
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Sparingly), Dichloromethane (Slightly)
pka
-1.99±0.20(Predicted)
form 
Crystalline Powder
color 
White to off-white
Sensitive 
Moisture Sensitive/Stench
InChI
InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3
InChIKey
VMKIXWAFFVLJCK-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(=O)C1
CAS DataBase Reference
398489-26-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-37/38-41
Safety Statements 
26-39
RIDADR 
UN 3335
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
696315
Product name
1-Boc-3-azetidinone
Purity
97%
Packaging
1g
Price
$97.1
Updated
2024/03/01
TCI Chemical
Product number
B3988
Product name
1-(tert-Butoxycarbonyl)-3-azetidinone
Purity
>98.0%(GC)
Packaging
1g
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
B3988
Product name
1-(tert-Butoxycarbonyl)-3-azetidinone
Purity
>98.0%(GC)
Packaging
5g
Price
$145
Updated
2024/03/01
Alfa Aesar
Product number
H50826
Product name
1-Boc-3-azetidinone, 95%
Packaging
1g
Price
$201
Updated
2021/12/16
Alfa Aesar
Product number
H50826
Product name
1-Boc-3-azetidinone, 95%
Packaging
250mg
Price
$51.8
Updated
2021/12/16
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tert-Butyl 3-oxoazetidine-1-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.

Uses

tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

General Description

tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.

Synthesis

The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.

tert-Butyl 3-oxoazetidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 3-oxoazetidine-1-carboxylate Suppliers

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View Lastest Price from tert-Butyl 3-oxoazetidine-1-carboxylate manufacturers

Nanjing Fred Technology Co., Ltd
Product
Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
PNP Biotech Co. Ltd
Product
Tert-Butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price
US $0.00/KG
Min. Order
25KG
Purity
96%
Supply Ability
Inquiry
Release date
2022-09-16
Shanghai Jinli Pharmaceutical Co.,Ltd
Product
Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
Price
US $1.00-1.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
30TONS
Release date
2023-01-31

398489-26-4, tert-Butyl 3-oxoazetidine-1-carboxylateRelated Search:

tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate N-BOC-3-AZA-HEPTAN-1-ONE 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate tert-Butyl (4-methylpiperidin-4-yl)carbamate tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate Theanine (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Methyl 8-azabicyclo[3.2.1... (R)-2-Aminomethyl-4-boc-morpholine (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate tert-Butyl 3-phenyl-L-alaninate hydrochloride tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate Cyclobutanone TERT-BUTYL 2-OXOAZETIDINE-1-CARBOXYLATE 3-AZETIDINONE

  • 1-BOC-3-AZETIDINONE
  • 3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • Azetidin-3-one, N-BOC protected 95%
  • tert-Butyl 3-oxoazetidine-1-carboxylate, 3-Oxoazetidine, N-BOC protected
  • N-(t-butoxycarbonyl)azetidin-3-one
  • tert-Butyl 3-oxoazetidine-1-carboxylat
  • 1-Boc-3-azetidinone 97%
  • 3-ketoazetidine-1-carboxylic acid tert-butyl ester
  • 3-oxo-1-azetidinecarboxylic acid tert-butyl ester
  • N-boc-3-azetidine
  • 1-Boc-3-azetidione
  • tert-Butyl 3-oxoazetidine-1-carb
  • 1-Boc-3-azeetidinone
  • Azetidin-3-one, N-BOC protected
  • 3-OXOAZETIDINE, N-BOC PROTECTED
  • TERT-BUTYL 3-OXOAZETIDINE-1-CARBOXYLATE
  • 1-TERT-BUTOXYCARBONYL-3-AZETIDINONE
  • 1-N-Boc-3-azetidinone
  • 3-Oxoazetidine, N-BOC protected 95%
  • 1-BOC-3-AZETIDINONE,97%
  • N-BOC-3-OXOAZETIDINE
  • 1-Azetidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester
  • 1-BOC-3-OXOAZETIDINE
  • 1-Boc-azetidin-3-one
  • 1-Boc-3-acetidinone
  • N-Boc-Azetidin-3-one
  • N-Boc-3-azetidinone
  • 3-Oxo-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester
  • tert-Butyl 3-Ox
  • t-Butyl 3-oxoazetidine-1-carboxylate
  • 1-Boc-3-azetidinone ,98%
  • 1-(tert-Butoxycarbonyl)-3-azetidinone &gt
  • Baricitinib-011
  • ert-Butyl3-oxoazetidine-1-carboxylate
  • 3-Oxo-azetidine-1-BOC
  • tert-butyl -3-oxozatidine-1-carboxylate
  • 1-Boc azitidone
  • 398489-26-4
  • 398498-26-4
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Ring Systems
  • pharmacetical
  • Heterocycles series
  • Azetidine
  • pharmaceutical and biochemical