tert-Butyl 3-oxoazetidine-1-carboxylate
- Product Name
- tert-Butyl 3-oxoazetidine-1-carboxylate
- CAS No.
- 398489-26-4
- Chemical Name
- tert-Butyl 3-oxoazetidine-1-carboxylate
- Synonyms
- 1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;N-Boc-Azetidin-3-one;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;N-boc-3-azetidine;1-Boc-3-azetidione;1-Boc-3-acetidinone
- CBNumber
- CB5282384
- Molecular Formula
- C8H13NO3
- Formula Weight
- 171.19
- MOL File
- 398489-26-4.mol
tert-Butyl 3-oxoazetidine-1-carboxylate Property
- Melting point:
- 47-51 °C
- Boiling point:
- 251.3±33.0 °C(Predicted)
- Density
- 1.174±0.06 g/cm3(Predicted)
- Flash point:
- 102 °C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), Dichloromethane (Slightly)
- pka
- -1.99±0.20(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- Sensitive
- Moisture Sensitive/Stench
- InChI
- InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3
- InChIKey
- VMKIXWAFFVLJCK-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CC(=O)C1
- CAS DataBase Reference
- 398489-26-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 22-37/38-41
- Safety Statements
- 26-39
- RIDADR
- UN 3335
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 696315
- Product name
- 1-Boc-3-azetidinone
- Purity
- 97%
- Packaging
- 1g
- Price
- $97.1
- Updated
- 2024/03/01
- Product number
- B3988
- Product name
- 1-(tert-Butoxycarbonyl)-3-azetidinone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- B3988
- Product name
- 1-(tert-Butoxycarbonyl)-3-azetidinone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $145
- Updated
- 2024/03/01
- Product number
- H50826
- Product name
- 1-Boc-3-azetidinone, 95%
- Packaging
- 1g
- Price
- $201
- Updated
- 2021/12/16
- Product number
- H50826
- Product name
- 1-Boc-3-azetidinone, 95%
- Packaging
- 250mg
- Price
- $51.8
- Updated
- 2021/12/16
tert-Butyl 3-oxoazetidine-1-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White to light brown solid
Uses
1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.
Uses
tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.
General Description
tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.
Synthesis
The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.
tert-Butyl 3-oxoazetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
tert-Butyl 3-oxoazetidine-1-carboxylate Suppliers
- Tel
- +918790379245
- banny.janga@btcpharm.com
- Country
- India
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- 1269
- Advantage
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- Tel
- +91 9891111994
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- Country
- India
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View Lastest Price from tert-Butyl 3-oxoazetidine-1-carboxylate manufacturers
- Product
- Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-29
- Product
- Tert-Butyl 3-oxoazetidine-1-carboxylate 398489-26-4
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 96%
- Supply Ability
- Inquiry
- Release date
- 2022-09-16
- Product
- Tert-butyl 3-oxoazetidine-1-carboxylate 398489-26-4
- Price
- US $1.00-1.00/KG
- Min. Order
- 25KG
- Purity
- 99%
- Supply Ability
- 30TONS
- Release date
- 2023-01-31