tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
- Product Name
- tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
- CAS No.
- 120871-73-0
- Chemical Name
- tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
- Synonyms
- N-Boc-4-allyl-3-pyrrolidinone;tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate;tert-butyl 3-oxo-4-(prop-2-en-1-yl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-oxo-4-(2-propenyl)-, 1,1-dimethylethylester;1-Pyrrolidinecarboxylic acid, 3-oxo-4-(2-propen-1-yl)-, 1,1-dimethylethyl ester
- CBNumber
- CB12733055
- Molecular Formula
- C12H19NO3
- Formula Weight
- 225.28
- MOL File
- 120871-73-0.mol
tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Property
- Boiling point:
- 305.8±35.0 °C(Predicted)
- Density
- 1.059±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -1.87±0.40(Predicted)
- Appearance
- Light yellow to yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B811728
- Product name
- tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B811728
- Product name
- tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B811728
- Product name
- tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- CHM1052397
- Product name
- TERT-BUTYL-3-ALLYL-4-OXOPYRROLIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.21
- Updated
- 2021/12/16
- Product number
- CM131098
- Product name
- tert-butyl3-allyl-4-oxopyrrolidine-1-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $804
- Updated
- 2021/12/16
tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
1374334-11-8
120871-73-0
Step 1, Method B: Synthesis of tert-butyl 3-pentyl-4-oxopyrrolidine-1-carboxylate. Tert-butyl 3-methyl-4-oxopyrrolidine-1,3-dicarboxylate (48.65 g, 0.20 mol) was dissolved in anhydrous toluene (800 mL) and allyl alcohol (300 mL) and dibutyltin oxide (5.0 g, 20 mmol) were added. The reaction was refluxed in a Dean-Stark manifold for 20 hours, during which time the azeotrope was removed 6 hours after the start of the reaction (200 mL total) and replenished with allyl alcohol (75 mL). Upon completion of the reaction, the reaction mixture was concentrated, and the residue was dissolved in a minimal volume of dichloromethane and purified by silica gel column chromatography (700 mL v/v), eluting sequentially with dichloromethane, 10% ethyl acetate/dichloromethane, 15% ethyl acetate/dichloromethane, and 20% ethyl acetate/dichloromethane to afford 3-allyl-1-tert-butyl-4-oxo-pyrrolidine-1,3-dicarboxylate (48.6 g, 90%) as a light pink oil (structure confirmed by NMR and MS). The compound (48.47 g, 0.18 mol) was dissolved in anhydrous tetrahydrofuran (200 mL), added to a stirred solution of Pd(PPh3)4 (4.16 g, 3.6 mmol) in anhydrous tetrahydrofuran (400 mL) under nitrogen protection, stirred for 4 h and concentrated. The residue was dissolved in heptane and purified by silica gel column chromatography (1000 mL v/v) eluting with 60:35:5 heptane/dichloromethane/ethyl acetate to afford tert-butyl 3-allyl-4-oxopyrrolidine-1-carboxylate (27.93 g, 69%) as a light yellow oil (structure confirmed by NMR and MS).
References
[1] Patent: WO2012/58065, 2012, A1. Location in patent: Page/Page column 49
tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate manufacturers
- Product
- tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate 120871-73-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-29