tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate

Product Name: tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
CAS No.: 120871-73-0
Chemical Name: tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
Synonyms: N-Boc-4-allyl-3-pyrrolidinone;tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate;tert-butyl 3-oxo-4-(prop-2-en-1-yl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-oxo-4-(2-propenyl)-, 1,1-dimethylethylester;1-Pyrrolidinecarboxylic acid, 3-oxo-4-(2-propen-1-yl)-, 1,1-dimethylethyl ester
CBNumber: CB12733055
Molecular Formula: C12H19NO3
Formula Weight: 225.28
MOL File: 120871-73-0.mol

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tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Property

Boiling point:: 305.8±35.0 °C(Predicted)
Density: 1.059±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.87±0.40(Predicted)
Appearance: Light yellow to yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B811728
Product name: tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B811728
Product name: tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
Packaging: 50mg
Price: $90
Updated: 2021/12/16

TRC

Product number: B811728
Product name: tert-Butyl3-Allyl-4-oxopyrrolidine-1-carboxylate
Packaging: 100mg
Price: $155
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM1052397
Product name: TERT-BUTYL-3-ALLYL-4-OXOPYRROLIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $502.21
Updated: 2021/12/16

Chemenu

Product number: CM131098
Product name: tert-butyl3-allyl-4-oxopyrrolidine-1-carboxylate
Purity: 97%
Packaging: 5g
Price: $804
Updated: 2021/12/16

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tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

1374334-11-8

120871-73-0

Step 1, Method B: Synthesis of tert-butyl 3-pentyl-4-oxopyrrolidine-1-carboxylate. Tert-butyl 3-methyl-4-oxopyrrolidine-1,3-dicarboxylate (48.65 g, 0.20 mol) was dissolved in anhydrous toluene (800 mL) and allyl alcohol (300 mL) and dibutyltin oxide (5.0 g, 20 mmol) were added. The reaction was refluxed in a Dean-Stark manifold for 20 hours, during which time the azeotrope was removed 6 hours after the start of the reaction (200 mL total) and replenished with allyl alcohol (75 mL). Upon completion of the reaction, the reaction mixture was concentrated, and the residue was dissolved in a minimal volume of dichloromethane and purified by silica gel column chromatography (700 mL v/v), eluting sequentially with dichloromethane, 10% ethyl acetate/dichloromethane, 15% ethyl acetate/dichloromethane, and 20% ethyl acetate/dichloromethane to afford 3-allyl-1-tert-butyl-4-oxo-pyrrolidine-1,3-dicarboxylate (48.6 g, 90%) as a light pink oil (structure confirmed by NMR and MS). The compound (48.47 g, 0.18 mol) was dissolved in anhydrous tetrahydrofuran (200 mL), added to a stirred solution of Pd(PPh3)4 (4.16 g, 3.6 mmol) in anhydrous tetrahydrofuran (400 mL) under nitrogen protection, stirred for 4 h and concentrated. The residue was dissolved in heptane and purified by silica gel column chromatography (1000 mL v/v) eluting with 60:35:5 heptane/dichloromethane/ethyl acetate to afford tert-butyl 3-allyl-4-oxopyrrolidine-1-carboxylate (27.93 g, 69%) as a light yellow oil (structure confirmed by NMR and MS).

References

[1] Patent: WO2012/58065, 2012, A1. Location in patent: Page/Page column 49

tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate 120871-73-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

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