Fostamatinib

ChemicalBook > CAS DataBase List > Fostamatinib

Binding Mode

Product Name: Fostamatinib
CAS No.: 901119-35-5
Chemical Name: Fostamatinib
Synonyms: R788;RT788;CS-883;R7935788;R-935788;R788 5MG;NSC-745942;Tavalisse);Fostatinib;R788, >=99%
CBNumber: CB52499223
Molecular Formula: C23H26FN6O9P
Formula Weight: 580.46
MOL File: 901119-35-5.mol

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Fostamatinib Property

Melting point:: 214° - 217°C
Boiling point:: 814.2±75.0 °C(Predicted)
Density: 1.496
storage temp.: -20°C, Hygroscopic
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 1.70±0.10(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 474099
Product name: Fostamatinib
Packaging: 100mg
Price: $1423
Updated: 2021/12/16

Matrix Scientific

Product number: 125210
Product name: Fostamatinib
Purity: 95+%
Packaging: 1g
Price: $3036
Updated: 2021/12/16

ChemScene

Product number: CS-2152
Product name: Fostamatinib
Purity: 99.20%
Packaging: 100mg
Price: $708
Updated: 2021/12/16

ApexBio Technology

Product number: B2284
Product name: Fostamatinib(R788)
Packaging: 100mg
Price: $713
Updated: 2021/12/16

AK Scientific

Product number: X2110
Product name: Fostamatinibdisodium
Packaging: 1g
Price: $4148
Updated: 2021/12/16

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Fostamatinib Chemical Properties,Usage,Production

Binding Mode

As shown in the co-crystal structure of tamatinib-SYK (Fig. 1), the aminopyrimidine moiety forms two hydrogen bonds with Ala451 of the hinge region. In addition, there is an atypical hydrogen bond (CH...O=C) between CH at 6 and amide carbonyl of Glu449 (Fig. 2).

Uses

Fostamatinib can be used to treat cancers that have acquired resistance to kinase inhibitors.

Indications

Fostamatinib is an FDA-approved first-in-class spleen tyrosine kinase (SYK) inhibitor, specifically indicated for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have not responded adequately to prior therapies.

brand name

Tavalisse

General Description

Class: non-receptor tyrosine kinase; Treatment: ITP; Other name: R788; Oral bioavailability = 100% (prodrug); Elimination half-life = 15 h (tamatinib); Protein binding = 98.3%

Biological Activity

fostamatinib is a small molecule inhibitor of spleen tyrosine kinase (syk) with ic50 value of 41nm [1].fostamatinib is an orally bioavailable prodrug of r406. it is developed for the treatment of autoimmune diseases. the effective metabolite of fostamatinib, r406, is an atp-competitive inhibitor of syk with ki value of 30nm. r406 also inhibits the activity of other kinases including flt3, lyn (ic50=63nm) and lck (ic50=37nm). it is found that r406 inhibits both bcr and fcr mediated responses in vitro. besides that, r406 also shows effects in other cells types and signalling pathways. in the in vivo assay, fostamatinib shows to be highly active to inhibit fcr-mediated signaling in various animal models of allergy, autoimmunity and inflammation. moreover, fostamatinib also exerts efficacy in sle animal models. treatment of fostamatinib suppresses the established renal and skin disease and reduces lymphadenopathy in the mrl/lpr strain [1].

target

Primary target: SYK

References

[1] mcadoo s p, tam f w k. fostamatinib disodium. drugs of the future, 2011, 36(4): 273.

Fostamatinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fostamatinib manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Fostamatinib (R788) 901119-35-5
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 99% HPLC
Supply Ability: 1000kg
Release date: 2024-11-21

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fostamatinib 901119-35-5
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 1000g
Release date: 2021-10-15

Hebei Yanxi Chemical Co., Ltd.

Product: Fostamatinib 901119-35-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-09

901119-35-5, FostamatinibRelated Search:

Fosaprepitant dimeglumine Combretastatin A4 phosphate disodium salt FostaMatinib DisodiuM Hexahydrate Poziotinib(HM 781-36B) Cabozantinib Dapoxetine hydrochloride AZD 3759 Dapoxetine Brigatinib Afatinib (BIBW 2992) Lorlatinib (PF-06463922) AZD-9291 NU7441 (KU-57788) Selumetinib Dasatinib Flavopiridol (Alvocidib) HCl Olaparib Canertinib

Fostamatinib

FostaMatinib DisodiuM

FostaMatinib (R788)

R788

NSC-745942

R-935788

R7935788

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one

(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate

R788, >=99%

FOSTAMATINIB (R788);R788

R788 5MG

RT788

[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

R 788;R-788;R788

CS-883

R788 (Fostamatinib, FosD, tamatinib fosdium)

R788 free base

2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-

Fostamatinib USP/EP/BP

sodium (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate

{[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]py rimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H- pyrido[3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic acid

Tavalisse)

Blessing him

Fostatinib

(6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate?, Fostamatinib

(6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate

901119-35-5

C23H26FN6O9P

Inhibitors

API